磁性介孔二氧化硅纳米药物载体的制备及其研究

Study on the Construction of Nanocarriers Based on Mesoporous Silica

摘要: 人们正在努力攻克癌症的治愈，努力探索治疗癌症的方法与技术。磁性介孔二氧化硅纳米药物载体的制备给癌症治疗提供了一个新的研究方向。利用共沉淀法制备Fe₃O₄纳米粒子，用CTAB做模板剂在Fe₃O₄的表面包裹SiO₂，随后在NaCl的乙醇溶液中搅拌去模版基，使Fe₃O₄外面形成介孔。实验中通过控制包裹时间，改变TEOS的用量，制备成形貌良好的磁性介孔二氧化硅纳米药物载体。最后对Fe₃O₄@mSiO₂进行表面巯基化修饰，使表面巯基化的Fe₃O₄@mSiO₂不仅能通过介孔载药，还能通过化学键载药，提高载体载药率。磁性介孔二氧化硅纳米药物载体的成功制备，为癌症治疗的靶向治疗带来新的研究方向。

Abstract: Human beings are working hard to conquer the cure of cancer and strive to explore the methods and techniques of treating cancer. The preparation of magnetic mesoporous silica nano-drug carrier provides a new research direction for cancer treatment. Fe₃O₄ nanoparticles were prepared by solvothermal method. SiO₂ was coated on the surface of Fe₃O₄ with CTAB as template. Then the template was stirred in the ethanol solution of NaCl to form mesopores outside Fe₃O₄. In the ex-periment, the magnetic mesoporous silica nanometer drug carrier with good morphology was prepared by controlling the time of the coating and changing the amount of TEOS. Finally, the op-timum dosage of TEOS was about 150 μl when the time was 6 hours. Finally, Fe₃O₄@mSiO₂ was modified by surface thiolation, so that the surface thiylated Fe₃O₄@mSiO₂ can not only through the mesoporous drug loading, but also through the chemical bond drug to improve the carrier drug loading rate. The successful preparation of magnetic mesoporous silica nano-drug carrier brings new research direction for targeted therapy of cancer treatment.