血小板与结直肠癌的研究现状
Research Status of Platelets and Colorectal Cancer
DOI: 10.12677/acm.2024.14112944, PDF,   
作者: 陈沪斌:绍兴文理学院医学院,浙江 绍兴
关键词: 结直肠癌血小板转移免疫逃逸Colorectal Cancer Platelet Metastasis Immune Escape
摘要: 本文概述了血小板在结直肠癌发展中的多重作用,尤其是在促进肿瘤转移、增强肿瘤细胞的耐药性及调控肿瘤微环境方面的关键功能。研究表明,血小板通过上皮–间质转化、肿瘤细胞诱导的血小板聚集等机制,增强肿瘤细胞的侵袭性及免疫逃逸能力。此外,血小板在辅助肠癌的诊断及治疗等方面也有其特殊的价值。
Abstract: This article outlines the multiple roles of platelets in the development of colorectal cancer, especially the key functions in promoting tumor metastasis, enhancing the drug resistance of tumor cells and regulating the tumor microenvironment. Studies show that platelets enhance the aggressiveness and immune escape ability of tumor cells through EMT, TCIPA and other mechanisms. In addition, platelets also have their special value in assisting in the diagnosis and treatment of intestinal cancer.
文章引用:陈沪斌. 血小板与结直肠癌的研究现状[J]. 临床医学进展, 2024, 14(11): 773-777. https://doi.org/10.12677/acm.2024.14112944

参考文献

[1] van der Meijden, P.E.J. and Heemskerk, J.W.M. (2018) Platelet Biology and Functions: New Concepts and Clinical Perspectives. Nature Reviews Cardiology, 16, 166-179. [Google Scholar] [CrossRef] [PubMed]
[2] Gaertner, F. and Massberg, S. (2019) Patrolling the Vascular Borders: Platelets in Immunity to Infection and Cancer. Nature Reviews Immunology, 19, 747-760. [Google Scholar] [CrossRef] [PubMed]
[3] Levin, J. (1964) Thrombocytosis Associated with Malignant Disease. Archives of Internal Medicine, 114, 497-500. [Google Scholar] [CrossRef] [PubMed]
[4] Chen, R., Jin, G., Li, W. and McIntyre, T.M. (2018) Epidermal Growth Factor (EGF) Autocrine Activation of Human Platelets Promotes EGF Receptor-Dependent Oral Squamous Cell Carcinoma Invasion, Migration, and Epithelial Mesenchymal Transition. The Journal of Immunology, 201, 2154-2164. [Google Scholar] [CrossRef] [PubMed]
[5] Chen, J., Zhai, E., Yuan, Y., Wu, K., Xu, J., Peng, J., et al. (2017) Systemic Immune-Inflammation Index for Predicting Prognosis of Colorectal Cancer. World Journal of Gastroenterology, 23, 6261-6272. [Google Scholar] [CrossRef] [PubMed]
[6] Giannakeas, V., Kotsopoulos, J., Cheung, M.C., Rosella, L., Brooks, J.D., Lipscombe, L., et al. (2022) Analysis of Platelet Count and New Cancer Diagnosis over a 10-Year Period. JAMA Network Open, 5, e2141633. [Google Scholar] [CrossRef] [PubMed]
[7] Scheel, C., Onder, T., Karnoub, A. and Weinberg, R.A. (2007) Adaptation versus Selection: The Origins of Metastatic Behavior. Cancer Research, 67, 11476-11480. [Google Scholar] [CrossRef] [PubMed]
[8] Labelle, M., Begum, S. and Hynes, R.O. (2011) Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis. Cancer Cell, 20, 576-590. [Google Scholar] [CrossRef] [PubMed]
[9] Derynck, R. and Zhang, Y.E. (2003) Smad-Dependent and Smad-Independent Pathways in TGF-β Family Signalling. Nature, 425, 577-584. [Google Scholar] [CrossRef] [PubMed]
[10] Egan, K., Cooke, N. and Kenny, D. (2014) Living in Shear: Platelets Protect Cancer Cells from Shear Induced Damage. Clinical & Experimental Metastasis, 31, 697-704. [Google Scholar] [CrossRef] [PubMed]
[11] Suzuki-Inoue, K. (2006) A Novel Syk-Dependent Mechanism of Platelet Activation by the C-Type Lectin Receptor Clec-2. Blood, 107, 542-549. [Google Scholar] [CrossRef] [PubMed]
[12] Reymond, N., d’Água, B.B. and Ridley, A.J. (2013) Crossing the Endothelial Barrier during Metastasis. Nature Reviews Cancer, 13, 858-870. [Google Scholar] [CrossRef] [PubMed]
[13] Läubli, H. and Borsig, L. (2010) Selectins as Mediators of Lung Metastasis. Cancer Microenvironment, 3, 97-105. [Google Scholar] [CrossRef] [PubMed]
[14] Bauer, A.T., Suckau, J., Frank, K., Desch, A., Goertz, L., Wagner, A.H., et al. (2015) Von Willebrand Factor Fibers Promote Cancer-Associated Platelet Aggregation in Malignant Melanoma of Mice and Humans. Blood, 125, 3153-3163. [Google Scholar] [CrossRef] [PubMed]
[15] Takagi, S., Sasaki, Y., Koike, S., Takemoto, A., Seto, Y., Haraguchi, M., et al. (2021) Platelet-Derived Lysophosphatidic Acid Mediated LPAR1 Activation as a Therapeutic Target for Osteosarcoma Metastasis. Oncogene, 40, 5548-5558. [Google Scholar] [CrossRef] [PubMed]
[16] Mammadova-Bach, E., Gil-Pulido, J., Sarukhanyan, E., Burkard, P., Shityakov, S., Schonhart, C., et al. (2020) Platelet Glycoprotein VI Promotes Metastasis through Interaction with Cancer Cell-Derived Galectin-3. Blood, 135, 1146-1160. [Google Scholar] [CrossRef] [PubMed]
[17] Zhang, W., Zhou, H., Li, H., Mou, H., Yinwang, E., Xue, Y., et al. (2023) Cancer Cells Reprogram to Metastatic State through the Acquisition of Platelet Mitochondria. Cell Reports, 42, Article ID: 113147. [Google Scholar] [CrossRef] [PubMed]
[18] Palumbo, J.S., Barney, K.A., Blevins, E.A., Shaw, M.A., Mishra, A., Flick, M.J., et al. (2008) Factor XIII Transglutaminase Supports Hematogenous Tumor Cell Metastasis through a Mechanism Dependent on Natural Killer Cell Function. Journal of Thrombosis and Haemostasis, 6, 812-819. [Google Scholar] [CrossRef] [PubMed]
[19] Zhang, Y., Manouchehri Doulabi, E., Herre, M., Cedervall, J., Qiao, Q., Miao, Z., et al. (2022) Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and TGFβ Signaling in the Tumor Microenvironment. Cancers, 14, Article No. 1947. [Google Scholar] [CrossRef] [PubMed]
[20] Placke, T., Örgel, M., Schaller, M., Jung, G., Rammensee, H., Kopp, H., et al. (2012) Platelet-Derived MHC Class I Confers a Pseudonormal Phenotype to Cancer Cells That Subverts the Antitumor Reactivity of Natural Killer Immune Cells. Cancer Research, 72, 440-448. [Google Scholar] [CrossRef] [PubMed]
[21] Zaslavsky, A.B., Adams, M.P., Cao, X., Maj, T., Choi, J.E., Stangl-Kremser, J., et al. (2020) Platelet PD-L1 Suppresses Anti-Cancer Immune Cell Activity in PD-L1 Negative Tumors. Scientific Reports, 10, Article No. 19296. [Google Scholar] [CrossRef] [PubMed]
[22] Dinkla, S., van Cranenbroek, B., van der Heijden, W.A., He, X., Wallbrecher, R., Dumitriu, I.E., et al. (2016) Platelet Microparticles Inhibit IL-17 Production by Regulatory T Cells through P-Selectin. Blood, 127, 1976-1986. [Google Scholar] [CrossRef] [PubMed]
[23] Lou, X.L., Sun, J., Gong, S.Q., et al. (2015) Interaction between Circulating Cancer Cells and Platelets: Clinical Implication. Chinese Journal of Cancer Research, 27, 450-460.
[24] Thun, M.J., Jacobs, E.J. and Patrono, C. (2012) The Role of Aspirin in Cancer Prevention. Nature Reviews Clinical Oncology, 9, 259-267. [Google Scholar] [CrossRef] [PubMed]
[25] Lakka Klement, G., Yip, T., Cassiola, F., Kikuchi, L., Cervi, D., Podust, V., et al. (2009) Platelets Actively Sequester Angiogenesis Regulators. Blood, 113, 2835-2842. [Google Scholar] [CrossRef] [PubMed]
[26] Josa, V., Ferenczi, S., Szalai, R., Fuder, E., Kuti, D., Horvath, K., et al. (2020) Thrombocytosis and Effects of IL-6 Knock-Out in a Colitis-Associated Cancer Model. International Journal of Molecular Sciences, 21, Article No. 6218. [Google Scholar] [CrossRef] [PubMed]
[27] Bottsford-Miller, J., Choi, H., Dalton, H.J., Stone, R.L., Cho, M.S., Haemmerle, M., et al. (2015) Differential Platelet Levels Affect Response to Taxane-Based Therapy in Ovarian Cancer. Clinical Cancer Research, 21, 602-610. [Google Scholar] [CrossRef] [PubMed]
[28] Hu, Z., Tan, S., Chen, S., Qin, S., Chen, H., Qin, S., et al. (2020) Diagnostic Value of Hematological Parameters Platelet to Lymphocyte Ratio and Hemoglobin to Platelet Ratio in Patients with Colon Cancer. Clinica Chimica Acta, 501, 48-52. [Google Scholar] [CrossRef] [PubMed]
[29] Shi, K., Damhofer, H., Daalhuisen, J., ten Brink, M., Richel, D.J. and Spek, C.A. (2017) Dabigatran Potentiates Gemcitabine-Induced Growth Inhibition of Pancreatic Cancer in Mice. Molecular Medicine, 23, 13-23. [Google Scholar] [CrossRef] [PubMed]
[30] Yap, M.L., McFadyen, J.D., Wang, X., Zia, N.A., Hohmann, J.D., Ziegler, M., et al. (2017) Targeting Activated Platelets: A Unique and Potentially Universal Approach for Cancer Imaging. Theranostics, 7, 2565-2574. [Google Scholar] [CrossRef] [PubMed]
[31] Giordano, A., Musumeci, G., D’Angelillo, A., Rossini, R., Biondi Zoccai, G., Messina, S., et al. (2016) Effects of Glycoprotein IIb/IIIa Antagonists: Anti Platelet Aggregation and Beyond. Current Drug Metabolism, 17, 194-203. [Google Scholar] [CrossRef] [PubMed]
[32] Trikha, M., Zhou, Z., Timar, J., et al. (2002) Multiple Roles for Platelet GPIIb/IIIa and Alphavbeta3 Integrins in Tumor Growth, Angiogenesis, and Metastasis. Cancer Research, 62, 2824-2833.
[33] Suzuki-Inoue, K. (2019) Platelets and Cancer-Associated Thrombosis: Focusing on the Platelet Activation Receptor CLEC-2 and Podoplanin. Blood, 134, 1912-1918. [Google Scholar] [CrossRef] [PubMed]
[34] Chang, Y., Hsieh, P., Chang, Y., Lu, M., Huang, T., Chong, K., et al. (2015) Identification of a Novel Platelet Antagonist That Binds to CLEC-2 and Suppresses Podoplanin-Induced Platelet Aggregation and Cancer Metastasis. Oncotarget, 6, 42733-42748. [Google Scholar] [CrossRef] [PubMed]
[35] Lucotti, S., Cerutti, C., Soyer, M., Gil-Bernabé, A.M., Gomes, A.L., Allen, P.D., et al. (2019) Aspirin Blocks Formation of Metastatic Intravascular Niches by Inhibiting Platelet-Derived Cox-1/Thromboxane A2. Journal of Clinical Investigation, 129, 1845-1862. [Google Scholar] [CrossRef] [PubMed]
[36] Rothwell, P.M., Wilson, M., Price, J.F., Belch, J.F., Meade, T.W. and Mehta, Z. (2012) Effect of Daily Aspirin on Risk of Cancer Metastasis: A Study of Incident Cancers during Randomised Controlled Trials. The Lancet, 379, 1591-1601. [Google Scholar] [CrossRef] [PubMed]