邻苯二甲酸酯类化合物在环境中的污染特征、生态风险及人体暴露
Pollution Characterization, Ecological Risks and Human Exposure to Phthalates in the Environment
DOI: 10.12677/ojns.2024.126138, PDF,   
作者: 范 洁：哈尔滨师范大学地理科学学院，黑龙江 哈尔滨
关键词: 邻苯二甲酸酯(PAEs)；污染特征；生态风险；人体暴露；Phthalates (PAEs)； Pollution Characterization； Ecological Risks； Human Exposure
摘要: 邻苯二甲酸酯(PAEs)是最重要且广泛使用的增塑剂。PAEs的生物累积性使其对环境的影响受到广泛关注。由于全球近年来的经济发展和人口增长，PAEs的生产和消费量大幅上升，对若干环境分区造成了相关的污染威胁。本综述的目的是系统地介绍各种环境介质(包括水环境、空气、土壤)中PAEs的存在情况，并评估人体对PAEs的暴露。这揭示了一种位置依赖性，这种依赖性可归因于经济和工业发展的区域差异以及特定的地理位置。确定了进一步研究PAEs在不同环境介质中的运输和转化行为以及PAEs控制技术的必要性，作为有效评估潜在生态和健康风险的一种手段。
Abstract: Phthalates (PAEs) are the most important and widely used plasticizers. The bioaccumulative nature of PAEs has led to widespread concern about their impact on the environment. As a result of global economic development and population growth in recent years, the production and consumption of PAEs have risen dramatically, posing an associated pollution threat to several environmental sub-regions. The aim of this review is to systematize the presence of PAEs in various environmental media (including the aqueous environment, air, and soil) and to assess human exposure to PAEs. This revealed a location dependence that can be attributed to regional differences in economic and industrial development as well as to specific geographic locations. The need for further studies on the transport and transformation behavior of PAEs in different environmental media and on control technologies for PAEs was identified as a means of effectively assessing potential ecological and health risks.
文章引用：范洁. 邻苯二甲酸酯类化合物在环境中的污染特征、生态风险及人体暴露[J]. 自然科学, 2024, 12(6): 1273-1282. https://doi.org/10.12677/ojns.2024.126138

参考文献

[1] Chang, W.-H., Herianto, S., Lee, C.-C., et al. (2021) The Effects of Phthalate Ester Exposure on Human Health: A Review. Science of the Total Environment, 786, Article ID: 147371. [Google Scholar] [CrossRef] [PubMed]
[2] Li, Y., Yan, H., Liu, Q., Li, X., Ge, J. and Yu, X. (2020) Accumulation and Transport Patterns of Six Phthalic Acid Esters (PAEs) in Two Leafy Vegetables under Hydroponic Conditions. Chemosphere, 249, Article 126457. [Google Scholar] [CrossRef] [PubMed]
[3] Krishnan, R.Y., Manikandan, S., Subbaiya, R., Karmegam, N., Kim, W. and Govarthanan, M. (2023) Recent Approaches and Advanced Wastewater Treatment Technologies for Mitigating Emerging Microplastics Contamination—A Critical Review. Science of the Total Environment, 858, Article 159681. [Google Scholar] [CrossRef] [PubMed]
[4] Zhang, Y., Guo, J., Xue, J., Bai, C. and Guo, Y. (2021) Phthalate Metabolites: Characterization, Toxicities, Global Distribution, and Exposure Assessment. Environmental Pollution, 291, Article 118106. [Google Scholar] [CrossRef] [PubMed]
[5] Sears, C.G. and Braun, J.M. (2021) Urinary Phthalate Metabolite Concentrations and Adolescent Sleep Duration. Environmental Epidemiology, 5, e134.
[6] Zamora, A.N., Peterson, K.E., Téllez-Rojo, M.M., Song, P.X.K., Meeker, J.D., Cantoral, A., et al. (2023) Urinary Phthalates, Phenols, and Parabens in Relation to Sleep Health Markers among a Cohort of Mexican Adolescents. Science of the Total Environment, 861, Article 160651. [Google Scholar] [CrossRef] [PubMed]
[7] Martin, L., Zhang, Y., First, O., Mustieles, V., Dodson, R., Rosa, G., et al. (2022) Lifestyle Interventions to Reduce Endocrine-Disrupting Phthalate and Phenol Exposures among Reproductive Age Men and Women: A Review and Future Steps. Environment International, 170, Article 107576. [Google Scholar] [CrossRef] [PubMed]
[8] Liu, N., Wen, F., Li, F., Zheng, X., Liang, Z. and Zheng, H. (2016) Inhibitory Mechanism of Phthalate Esters on Karenia Brevis. Chemosphere, 155, 498-508. [Google Scholar] [CrossRef] [PubMed]
[9] Thomsen, M., Rasmussen, A.G. and Carlsen, L. (1999) SAR/QSAR Approaches to Solubility, Partitioning and Sorption of Phthalates. Chemosphere, 38, 2613-2624. [Google Scholar] [CrossRef] 
[10] Gao, D. and Wen, Z. (2016) Phthalate Esters in the Environment: A Critical Review of Their Occurrence, Biodegradation, and Removal during Wastewater Treatment Processes. Science of the Total Environment, 541, 986-1001. [Google Scholar] [CrossRef] [PubMed]
[11] Gobas, F.A.P.C., Mackintosh, C.E., Webster, G., Ikonomou, M., Parkerton, T.F. and Robillard, K. (2002) Bioaccumulation of Phthalate Esters in Aquatic Food-Webs. In: The Handbook of Environmental Chemistry, Springer, 201-225. [Google Scholar] [CrossRef] 
[12] Huang, P., Tien, C., Sun, Y., Hsieh, C. and Lee, C. (2008) Occurrence of Phthalates in Sediment and Biota: Relationship to Aquatic Factors and the Biota-Sediment Accumulation Factor. Chemosphere, 73, 539-544. [Google Scholar] [CrossRef] [PubMed]
[13] Clausen, P.A., Xu, Y., Kofoed-Sørensen, V., Little, J.C. and Wolkoff, P. (2007) The Influence of Humidity on the Emission of Di-(2-Ethylhexyl) Phthalate (DEHP) from Vinyl Flooring in the Emission Cell “FLEC”. Atmospheric Environment, 41, 3217-3224. [Google Scholar] [CrossRef] 
[14] Babu, B. and Wu, J. (2010) Production of Phthalate Esters by Nuisance Freshwater Algae and Cyanobacteria. Science of the Total Environment, 408, 4969-4975. [Google Scholar] [CrossRef] [PubMed]
[15] Planelló, R., Herrero, O., Martínez-Guitarte, J.L. and Morcillo, G. (2011) Comparative Effects of Butyl Benzyl Phthalate (BBP) and Di(2-Ethylhexyl) Phthalate (DEHP) on the Aquatic Larvae of Chironomus Riparius Based on Gene Expression Assays Related to the Endocrine System, the Stress Response and Ribosomes. Aquatic Toxicology, 105, 62-70. [Google Scholar] [CrossRef] [PubMed]
[16] Gao, D., Li, Z., Wang, H. and Liang, H. (2018) An Overview of Phthalate Acid Ester Pollution in China over the Last Decade: Environmental Occurrence and Human Exposure. Science of the Total Environment, 645, 1400-1409. [Google Scholar] [CrossRef] [PubMed]
[17] Klein, D., Kessler, W., Semder, B., Pütz, C., Lichtmannegger, J., Otter, R., et al. (2016) Di-(2-Propylheptyl) Phthalate (DPHP) and Its Metabolites in Blood of Rats Upon Single Oral Administration of DPHP. Toxicology Letters, 259, 80-86. [Google Scholar] [CrossRef] [PubMed]
[18] Vitali, M. (1997) Phthalate Esters in Freshwaters as Markers of Contamination Sources—A Site Study in Italy. Environment International, 23, 337-347. [Google Scholar] [CrossRef] 
[19] Suttiviriya, T. and Kongpran, J. (2022) Contamination and Ecological Risk of Microplastics and Phthalates in the Surface Water of the Tha Dee Sub-River Basin, Nakhon Si Thammarat Province, Thailand. Journal of Environmental Science and Health, Part A, 57, 448-459.
[20] Xu, H., Liu, Y., Xu, X., Lan, H., Qi, W., Wang, D., et al. (2022) Spatiotemporal Variation and Risk Assessment of Phthalate Acid Esters (PAEs) in Surface Water of the Yangtze River Basin, China. Science of the Total Environment, 836, Article 155677. [Google Scholar] [CrossRef] [PubMed]
[21] He, W., Qin, N., Kong, X., Liu, W., He, Q., Ouyang, H., et al. (2013) Spatio-temporal Distributions and the Ecological and Health Risks of Phthalate Esters (Paes) in the Surface Water of a Large, Shallow Chinese Lake. Science of the Total Environment, 461, 672-680. [Google Scholar] [CrossRef] [PubMed]
[22] Li, Y., He, W., Liu, W., Yang, B., He, Q., Yang, C., et al. (2020) Impacts of Anthropogenic Activities on Spatial Variations of Phthalate Esters in Water and Suspended Particulate Matter from China’s Lakes. Science of the Total Environment, 724, Article 138281. [Google Scholar] [CrossRef] [PubMed]
[23] Félix-Cañedo, T.E., Durán-Álvarez, J.C. and Jiménez-Cisneros, B. (2013) The Occurrence and Distribution of a Group of Organic Micropollutants in Mexico City’s Water Sources. Science of the Total Environment, 454, 109-118. [Google Scholar] [CrossRef] [PubMed]
[24] Li, R., Liang, J., Gong, Z., Zhang, N. and Duan, H. (2017) Occurrence, Spatial Distribution, Historical Trend and Ecological Risk of Phthalate Esters in the Jiulong River, Southeast China. Science of the Total Environment, 580, 388-397. [Google Scholar] [CrossRef] [PubMed]
[25] Zhu, Q., Xu, L., Wang, W., Liu, W., Liao, C. and Jiang, G. (2022) Occurrence, Spatial Distribution and Ecological Risk Assessment of Phthalate Esters in Water, Soil and Sediment from Yangtze River Delta, China. Science of the Total Environment, 806, Article 150966. [Google Scholar] [CrossRef] [PubMed]
[26] Kotowska, U., Kapelewska, J. and Sawczuk, R. (2020) Occurrence, Removal, and Environmental Risk of Phthalates in Wastewaters, Landfill Leachates, and Groundwater in Poland. Environmental Pollution, 267, Article 115643. [Google Scholar] [CrossRef] [PubMed]
[27] Liu, X., Shi, J., Bo, T., Zhang, H., Wu, W., Chen, Q., et al. (2014) Occurrence of Phthalic Acid Esters in Source Waters: A Nationwide Survey in China during the Period of 2009-2012. Environmental Pollution, 184, 262-270. [Google Scholar] [CrossRef] [PubMed]
[28] Zhang, Z., Yang, G., Zhang, H., Shi, X., Zou, Y. and Zhang, J. (2020) Phthalic Acid Esters in the Sea-Surface Microlayer, Seawater and Sediments of the East China Sea: Spatiotemporal Variation and Ecological Risk Assessment. Environmental Pollution, 259, Article 113802. [Google Scholar] [CrossRef] [PubMed]
[29] Zhang, Z., Zhang, H., Zhang, J., Wang, Q. and Yang, G. (2018) Occurrence, Distribution, and Ecological Risks of Phthalate Esters in the Seawater and Sediment of Changjiang River Estuary and Its Adjacent Area. Science of the Total Environment, 619, 93-102. [Google Scholar] [CrossRef] [PubMed]
[30] Wang, L., Gu, Y., Zhang, Z., Sun, A., Shi, X., Chen, J., et al. (2021) Contaminant Occurrence, Mobility and Ecological Risk Assessment of Phthalate Esters in the Sediment-Water System of the Hangzhou Bay. Science of the Total Environment, 770, Article 144705. [Google Scholar] [CrossRef] [PubMed]
[31] Fu, J., Zhang, H., Li, R., Shi, T., Gao, H., Jin, S., et al. (2023) Occurrence, Spatial Patterns, Air-Seawater Exchange, and Atmospheric Deposition of Polycyclic Aromatic Hydrocarbons (PAHs) from the Northwest Pacific to Arctic Ocean. Marine Environmental Research, 183, Article 105793. [Google Scholar] [CrossRef] [PubMed]
[32] He, L., Gielen, G., Bolan, N.S., Zhang, X., Qin, H., Huang, H., et al. (2014) Contamination and Remediation of Phthalic Acid Esters in Agricultural Soils in China: A Review. Agronomy for Sustainable Development, 35, 519-534. [Google Scholar] [CrossRef] 
[33] Wang, W., Zhang, Y., Wang, S., Fan, C.Q. and Xu, H. (2011) Distributions of Phthalic Esters Carried by Total Suspended Particulates in Nanjing, China. Environmental Monitoring and Assessment, 184, 6789-6798. [Google Scholar] [CrossRef] [PubMed]
[34] Rudel, R.A., Dodson, R.E., Perovich, L.J., Morello-Frosch, R., Camann, D.E., Zuniga, M.M., et al. (2010) Semivolatile Endocrine-Disrupting Compounds in Paired Indoor and Outdoor Air in Two Northern California Communities. Environmental Science & Technology, 44, 6583-6590. [Google Scholar] [CrossRef] [PubMed]
[35] Sun, J., Pan, L., Zhan, Y., Lu, H., Tsang, D.C.W., Liu, W., et al. (2016) Contamination of Phthalate Esters, Organochlorine Pesticides and Polybrominated Diphenyl Ethers in Agricultural Soils from the Yangtze River Delta of China. Science of the Total Environment, 544, 670-676. [Google Scholar] [CrossRef] [PubMed]
[36] Niu, L., Xu, Y., Xu, C., Yun, L. and Liu, W. (2014) Status of Phthalate Esters Contamination in Agricultural Soils across China and Associated Health Risks. Environmental Pollution, 195, 16-23. [Google Scholar] [CrossRef] [PubMed]
[37] Kong, S., Ji, Y., Liu, L., Chen, L., Zhao, X., Wang, J., et al. (2012) Diversities of Phthalate Esters in Suburban Agricultural Soils and Wasteland Soil Appeared with Urbanization in China. Environmental Pollution, 170, 161-168. [Google Scholar] [CrossRef] [PubMed]
[38] Kong, S., Ji, Y., Liu, L., Chen, L., Zhao, X., Wang, J., et al. (2013) Spatial and Temporal Variation of Phthalic Acid Esters (PAEs) in Atmospheric PM10 and PM2.5 and the Influence of Ambient Temperature in Tianjin, China. Atmospheric Environment, 74, 199-208. [Google Scholar] [CrossRef] 
[39] Sun, J., Pan, L., Tsang, D.C.W., Zhan, Y., Zhu, L. and Li, X. (2018) Organic Contamination and Remediation in the Agricultural Soils of China: A Critical Review. Science of the Total Environment, 615, 724-740. [Google Scholar] [CrossRef] [PubMed]
[40] Buckley, J.P., Whyatt, R.M., et al. (2018) Prenatal Phthalate Exposures and Body Mass Index among 4 to 7-Year-old Children: A Pooled Analysis. Epidemiology, 27, 449-458.
[41] Oehlmann, J., Schulte-Oehlmann, U., et al. (2009) A Critical Analysis of the Biological Impacts of Plasticizers on Wildlife. Philosophical Transactions of the Royal Society B, 364, 2047-2062.
[42] Ye, T., Kang, M., Huang, Q., Fang, C., Chen, Y., Shen, H., et al. (2014) Exposure to DEHP and MEHP from Hatching to Adulthood Causes Reproductive Dysfunction and Endocrine Disruption in Marine Medaka (Oryzias Melastigma). Aquatic Toxicology, 146, 115-126. [Google Scholar] [CrossRef] [PubMed]
[43] Parkerton, T.F. and Konkel, W.J. (2000) Application of Quantitative Structure-Activity Relationships for Assessing the Aquatic Toxicity of Phthalate Esters. Ecotoxicology and Environmental Safety, 45, 61-78. [Google Scholar] [CrossRef] [PubMed]
[44] Koniecki, D., Wang, R., Moody, R.P. and Zhu, J. (2011) Phthalates in Cosmetic and Personal Care Products: Concentrations and Possible Dermal Exposure. Environmental Research, 111, 329-336. [Google Scholar] [CrossRef] [PubMed]
[45] Wormuth, M., Scheringer, M., Fau-Vollenweider, M., et al. (2006) What Are the Sources of Exposure to Eight Frequently Used Phthalic Acid Esters in Europeans? Risk Analysis, 26, 803-824.
[46] Chen, X., Xu, S., Tan, T., Lee, S., Cheng, S., Lee, F., et al. (2014) Toxicity and Estrogenic Endocrine Disrupting Activity of Phthalates and Their Mixtures. International Journal of Environmental Research and Public Health, 11, 3156-3168. [Google Scholar] [CrossRef] [PubMed]
[47] Jiang, J., Mu, D., Ding, M., Zhang, S., Zhang, H. and Hu, J. (2018) Simultaneous Determination of Primary and Secondary Phthalate Monoesters in the Taihu Lake: Exploration of Sources. Chemosphere, 202, 17-24. [Google Scholar] [CrossRef] [PubMed]
[48] Li, L.X., Meng, X.-Z., et al. (2013) Exposure Levels of Environmental Endocrine Disruptors in Mother-Newborn Pairs in China and Their Placental Transfer Characteristics. PLOS ONE, 8, e62526.
[49] Gao, C., Liu, L., Ma, W., Ren, N., Guo, Y., Zhu, N., et al. (2016) Phthalate Metabolites in Urine of Chinese Young Adults: Concentration, Profile, Exposure and Cumulative Risk Assessment. Science of the Total Environment, 543, 19-27. [Google Scholar] [CrossRef] [PubMed]