中医药调控胃癌细胞铁死亡在治疗胃癌的研究进展
Research Progress of Chinese Medicine Regulating Cellular Ferroptosis of Gastric Cancer Cells in the Treatment of Gastric Cancer
DOI: 10.12677/tcm.2024.1311434, PDF,   
作者: 苏云飞, 谭雪春：广西中医药大学研究生学院，广西 南宁；陈远能：广西中医药大学附属瑞康医院消化内科，广西 南宁
关键词: 铁死亡；胃癌细胞；胃癌；中草药：作用机制；Cellular Ferroptosis； Gastric Cancer Cells； Gastric Cancer； Chinese Herbal Medicine: Mechanism of Action
摘要: 胃癌是原发于胃黏膜上皮的恶性肿瘤，一般早期无明显症状，进展期乃至晚期才出现症状，加大治疗的难度，导致生存期限短、预后差等。胃癌细胞是胃癌的重要组成细胞，在胃癌发生发展过程中发挥着重要作用。铁死亡作为一种铁依赖性的新型细胞死亡形式，可以通过诱导胃癌细胞铁死亡，从而有效抑制胃癌进展，达到治疗目的。目前中医药在肿瘤的防治过程中体现出独特优势及巨大潜力，本文总结中草药与胃癌细胞铁死亡的作用关系，对中草药如何调控胃癌细胞铁死亡相关通路，进而诱导胃癌细胞死亡，并抑制胃癌的进展等方面进行综述，以期为胃癌的临床治疗提供思路。
Abstract: Gastric cancer is a malignant tumor originated from the gastric mucosal epithelium. Generally, there are no obvious symptoms in the early stage, and symptoms only appear in the advanced stage or even the late stage, which increases the difficulty of treatment, leading to short survival time and poor prognosis. Gastric cancer cells are important components of gastric cancer and play an important role in the occurrence and development of gastric cancer. Cellular ferroptosis, as a new type of iron-dependent cell death, can effectively inhibit the progression of gastric cancer by inducing cellular ferroptosis of gastric cancer cells, and achieve the purpose of treatment. At present, traditional Chinese medicine shows unique advantages and great potential in the prevention and treatment of cancer. This paper summarizes the relationship between Chinese herbs and cellular ferroptosis of gastric cancer cells, and reviews how Chinese herbs regulate cellular ferroptosis related pathways of gastric cancer cells, thus inducing the death of gastric cancer cells and inhibiting the progression of gastric cancer, with a view to providing ideas for the clinical treatment of gastric cancer.
文章引用：苏云飞, 谭雪春, 陈远能. 中医药调控胃癌细胞铁死亡在治疗胃癌的研究进展[J]. 中医学, 2024, 13(11): 2931-2938. https://doi.org/10.12677/tcm.2024.1311434

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