黄连改善IR的作用机制研究
Study on the Mechanism of Coptis chinensis in Improving Insulin Resistance
DOI: 10.12677/acm.2024.14112985, PDF,   
作者: 赵芸峰, 刘影哲*：黑龙江中医药大学第一临床医学院，黑龙江 哈尔滨
关键词: 黄连；胰岛素抵抗；作用机制；Coptis chinensis； Insulin Resistance； Mechanism of Action
摘要: 胰岛素抵抗(insulin resistance, IR)是代谢综合征的首位致病因素，严重威胁患者生命健康。传统中医药在胰岛素抵抗的治疗中具有重要潜力作用，黄连作为清热药的代表，记载有止消渴之功。黄连中有效成分包括小檗碱、黄连碱、药根碱等，能够通过多途径多靶点改善IR，其具有调节胰岛素信号通路、调节肠道菌群、下调炎症因子表达、调节GLP-1等多种药理作用。本文参考近年来黄连相关制剂改善IR的临床研究和动物实验，对黄连在IR发生发展过程中起到的作用机制进行归纳总结，以期为临床应用黄连治疗IR提供更好的治疗策略和理论依据。
Abstract: Insulin resistance (IR) is the leading causative factor of metabolic syndrome and seriously threatens the life and health of patients. Traditional Chinese medicine has an important potential role in the treatment of insulin resistance, and Coptis chinensis, as a representative of heat-clearing medicine, has been recorded to quench thirst. The active ingredients in Coptis chinensis include berberine, berberine, rhizomeline, etc., which can improve IR through multiple pathways and targets, and have various pharmacological effects such as regulating insulin signalling pathway, regulating intestinal flora, down-regulating the expression of inflammatory factors, and regulating GLP-1. This article summarises the mechanism of action of Coptis chinensis in the process of IR occurrence and development with reference to the clinical research and animal experiments on the improvement of IR by Coptis chinensis related preparations, in order to provide a better treatment strategy and theoretical basis for the clinical application of Coptis chinensis in the treatment of IR.
文章引用：赵芸峰, 刘影哲. 黄连改善IR的作用机制研究[J]. 临床医学进展, 2024, 14(11): 1075-1081. https://doi.org/10.12677/acm.2024.14112985

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