垂体神经内分泌肿瘤病例报道1例并文献复习
Pituitary Neuroendocrine Tumor: A Case Report and Review of Literature
DOI: 10.12677/acm.2024.14112989, PDF,   
作者: 龙浩健*, 周镇锋*, 黎 山*, 杨 兰*:暨南大学第一临床医学院,广东 广州;赵建夫#, 陈文慧#:暨南大学附属第一医院(广州华侨医院)肿瘤科,广东 广州
关键词: 泌乳素巨腺瘤垂体垂体神经内分泌瘤磁共振成像Prolactin Giant Adenoma Hypophysis PitNET Magnetic Resonance Imaging
摘要: 垂体催乳素腺瘤(prolactin-secreting adenoma, PRLoma)是最常见的功能性垂体腺瘤,约占成人垂体功能性腺瘤的40%,泌乳素微腺瘤较为常见,很少发展为大腺瘤,最大直径大于40 mm的泌乳素巨腺瘤并不常见。本文报道1例43岁男性患者,检查颅脑CT初次发现鼻咽部肿物时显示鼻咽区占位54 mm × 55 mm,已达到泌乳素巨腺瘤标准。本文针对催乳素瘤的诊断、鉴别及治疗策略进行文献回顾。
Abstract: Prolactin-secreting adenoma (PRLoma) is the most prevalent functional pituitary adenoma, accounting for approximately 40% of adult functional pituitary adenomas. Prolactin microadenomas are relatively common and rarely progress into large adenomas. Prolactin giant adenomas with a maximum diameter exceeding 40 mm are infrequent occurrences. In this paper, we present a case study of a 43-year-old male patient diagnosed with a nasopharyngeal mass measuring 54 mm × 55 mm through craniocranial CT scan, which fulfills the criteria for prolactin giant adenoma. This article provides an overview of the literature concerning the diagnosis, differentiation, and treatment of prolactinoma.
文章引用:龙浩健, 周镇锋, 黎山, 杨兰, 赵建夫, 陈文慧. 垂体神经内分泌肿瘤病例报道1例并文献复习[J]. 临床医学进展, 2024, 14(11): 1103-1110. https://doi.org/10.12677/acm.2024.14112989

参考文献

[1] Colao, A. (2009) The Prolactinoma. Best Practice & Research Clinical Endocrinology & Metabolism, 23, 575-596. [Google Scholar] [CrossRef] [PubMed]
[2] Moraes, A.B., Marques dos Santos Silva, C., Vieira Neto, L. and Gadelha, M.R. (2013) Giant Prolactinomas: The Therapeutic Approach. Clinical Endocrinology, 79, 447-456. [Google Scholar] [CrossRef] [PubMed]
[3] Maiter, D. and Delgrange, E. (2014) Therapy of Endocrine Disease: The Challenges in Managing Giant Prolactinomas. European Journal of Endocrinology, 170, R213-R227. [Google Scholar] [CrossRef] [PubMed]
[4] Fernandez, A., Karavitaki, N. and Wass, J.A.H. (2010) Prevalence of Pituitary Adenomas: A Community-Based, Cross-Sectional Study in Banbury (Oxfordshire, UK). Clinical Endocrinology, 72, 377-382. [Google Scholar] [CrossRef] [PubMed]
[5] Shimon, I., Sosa, E., Mendoza, V., Greenman, Y., Tirosh, A., Espinosa, E., et al. (2016) Giant Prolactinomas Larger than 60 Mm in Size: A Cohort of Massive and Aggressive Prolactin-Secreting Pituitary Adenomas. Pituitary, 19, 429-436. [Google Scholar] [CrossRef] [PubMed]
[6] Shimon, I. (2021) Prolactinomas: Diagnosis and Medical Treatment. In: Pituitary Tumors, Elsevier, 175-185. [Google Scholar] [CrossRef
[7] Guaraldi, F., Ambrosi, F., Ricci, C., Di Sciascio, L. and Asioli, S. (2024) Histopathology of Growth Hormone-Secreting Pituitary Tumors: State of the Art and New Perspectives. Best Practice & Research Clinical Endocrinology & Metabolism, 38, Article 101894. [Google Scholar] [CrossRef] [PubMed]
[8] Tsukamoto, T. and Miki, Y. (2023) Imaging of Pituitary Tumors: An Update with the 5th WHO Classifications—Part 1. Pituitary Neuroendocrine Tumor (Pitnet)/Pituitary Adenoma. Japanese Journal of Radiology, 41, 789-806. [Google Scholar] [CrossRef] [PubMed]
[9] Fujino, K., Yasufuku, K., Kudoh, S., Motooka, Y., Sato, Y., Wakimoto, J., et al. (2017) INSM1 Is the Best Marker for the Diagnosis of Neuroendocrine Tumors: Comparison with CGA, SYP and CD56. International Journal of Clinical and Experimental Pathology, 10, 5393-5405.
[10] Asa, S.L., Mete, O., Perry, A. and Osamura, R.Y. (2022) Overview of the 2022 WHO Classification of Pituitary Tumors. Endocrine Pathology, 33, 6-26. [Google Scholar] [CrossRef] [PubMed]
[11] Asa, S.L., Casar-Borota, O., Chanson, P., Delgrange, E., Earls, P., Ezzat, S., et al. (2017) From Pituitary Adenoma to Pituitary Neuroendocrine Tumor (Pitnet): An International Pituitary Pathology Club Proposal. Endocrine-Related Cancer, 24, C5-C8. [Google Scholar] [CrossRef] [PubMed]
[12] Rindi, G., Klimstra, D.S., Abedi-Ardekani, B., Asa, S.L., Bosman, F.T., Brambilla, E., et al. (2018) A Common Classification Framework for Neuroendocrine Neoplasms: An International Agency for Research on Cancer (IARC) and World Health Organization (WHO) Expert Consensus Proposal. Modern Pathology, 31, 1770-1786. [Google Scholar] [CrossRef] [PubMed]
[13] Lee, C.H. (2023) Pituitary Neuroendocrine Tumor: Is It Benign or Malignant? Brain Tumor Research and Treatment, 11, 173-176. [Google Scholar] [CrossRef] [PubMed]
[14] Villa, C., Baussart, B., Assié, G., Raverot, G. and Roncaroli, F. (2023) The World Health Organization Classifications of Pituitary Neuroendocrine Tumours: A Clinico-Pathological Appraisal. Endocrine-Related Cancer, 30, e230021. [Google Scholar] [CrossRef] [PubMed]
[15] Delellis, R.A., Lloyd, R.V. and Heitz, P.U. (2004) World Health Organization Classification Classification of Tumours: Pathology and Genetics of Tumours of Endocrine Organs.
[16] Al-Shraim, M. and Asa, S.L. (2005) The 2004 World Health Organization Classification of Pituitary Tumors: What Is New? Acta Neuropathologica, 111, 1-7. [Google Scholar] [CrossRef] [PubMed]
[17] Saeger, W., Lüdecke, D.K., Buchfelder, M., Fahlbusch, R., Quabbe, H. and Petersenn, S. (2007) Pathohistological Classification of Pituitary Tumors: 10 Years of Experience with the German Pituitary Tumor Registry. European Journal of Endocrinology, 156, 203-216. [Google Scholar] [CrossRef] [PubMed]
[18] Kovacs, K., Rotondo, F., Horvath, E., Syro, L.V., Di Ieva, A., Cusimano, M.D., et al. (2014) Letter to the Editor. Endocrine Pathology, 26, 93-94. [Google Scholar] [CrossRef] [PubMed]
[19] Raverot, G., Burman, P., McCormack, A., Heaney, A., Petersenn, S., Popovic, V., et al. (2018) European Society of Endocrinology Clinical Practice Guidelines for the Management of Aggressive Pituitary Tumours and Carcinomas. European Journal of Endocrinology, 178, G1-G24. [Google Scholar] [CrossRef] [PubMed]
[20] Di Ieva, A., Rotondo, F., Syro, L.V., Cusimano, M.D. and Kovacs, K. (2014) Aggressive Pituitary Adenomas—Diagnosis and Emerging Treatments. Nature Reviews Endocrinology, 10, 423-435. [Google Scholar] [CrossRef] [PubMed]
[21] Lloyd, R.V. (2017) WHO Classification of Tumours of Endocrine Organs. 4th Edition, IARC Publications.
[22] Mete, O. and Lopes, M.B. (2017) Overview of the 2017 WHO Classification of Pituitary Tumors. Endocrine Pathology, 28, 228-243. [Google Scholar] [CrossRef] [PubMed]
[23] Lenders, N.F., Earls, P.E., Inder, W.J. and McCormack, A.I. (2023) The Evolution in Pituitary Tumour Classification: A Clinical Perspective. Endocrine Oncology, 3, e220079. [Google Scholar] [CrossRef] [PubMed]