碱性成纤维细胞生长因子在鼓膜穿孔中的应用

Application of Basic Fibroblast Growth Factor in Tympanic Membrane Perforation

摘要: 鼓膜穿孔(tympanic membrane perforation, TMP)是耳鼻咽喉科常见的疾病，根据病程可分为急性穿孔和慢性穿孔，对于急性穿孔的处理往往是等待其自发愈合，而慢性TMP通常需要手术治疗，手术费用高，需要高级的耳科设备，且自身移植材料会造成取材部位的损伤。生物材料在鼓膜的修复中显示出巨大的潜力，包括细胞、支架以及生长因子。其中，碱性成纤维细胞生长因子(bFGF)可以促进成纤维细胞的增殖和残留鼓膜中纤维层的血运重建，从而促进鼓膜愈合，在鼓膜穿孔的非手术治疗中起了重要的作用，本文将碱性成纤维细胞生长因子在TMP中的应用作以综述，希望为TMP的治疗提供新思路。

Abstract: Tympanic membrane perforation (TMP) is a common disease in otolaryngology, which can be divided into acute perforation and chronic perforation according to the course of disease. At present, the treatment of acute tympanic membrane perforation is often to wait for its spontaneous healing, while chronic tympanic membrane perforation usually requires surgical treatment, which is expensive, requires advanced ear equipment, and self-transplantation materials will cause damage to the site. Biomaterials show great potential in the repair of tympanic membranes, including cells, scaffolds, and growth factors. Among them, fibroblast growth factor 2 (bFGF) can promote the proliferation of fibroblasts and the revascularization of the fibrous layer in the tympanic membrane residue, so as to promote the healing of the tympanic membrane, which plays an important role in non-operation treatment of TMP. In this paper, we review the application of bFGF and its related derivatives in TMP, hoping to provide a new treatment selection for repairing tympanic membrane.