胶原蛋白在妇产科的研究进展
Research Progress of Collagen in Obstetrics and Gynecology
DOI: 10.12677/acm.2024.14123049, PDF,    科研立项经费支持
作者: 曹晓静：首都医科大学电力教学医院妇产科，北京；仇舒曼：山西医科大学护理学院，山西 太原；马 乐*：首都医科大学附属北京妇产医院女性泌尿外科，北京
关键词: 胶原蛋白；妇产科；女性；生物医学应用；Collagen； Obstetrics and Gynecology； Female； Biomedical Applications
摘要: 胶原蛋白作为细胞外基质的重要组成成分广泛存在于人体各组织脏器。目前重组胶原蛋白作为一种重要的生物材料已广泛应用于医学多学科。本文简述了胶原蛋白的生理作用，发展及应用历史。分析了其女性机体内的分布特点、作用及影响因素。着重介绍了胶原蛋白在妇产科领域如妇科手术，常见妇科疾病，妇科肿瘤，妊娠相关疾病，女性抗衰老等多方面的研究及应用。探讨了胶原蛋白在妇产科方向的最新研究进展及广阔发展前景。
Abstract: As an important component of extracellular matrix, collagen widely exists in various tissues and organs of human body. At present, recombinant collagen, as an important biomaterial, has been widely used in many medical disciplines. In this paper, the physiological function, development and application history of collagen were briefly reviewed. The distribution characteristics, functions and influencing factors in female body were analyzed. This paper focuses on the research and application of collagen in gynecology and obstetrics, such as gynecological surgery, common gynecological diseases, gynecological tumors, pregnancy-related diseases, and female anti-aging. The latest research progress and broad development prospect of collagen in obstetrics and gynecology were discussed.
文章引用：曹晓静, 仇舒曼, 马乐. 胶原蛋白在妇产科的研究进展[J]. 临床医学进展, 2024, 14(12): 75-83. https://doi.org/10.12677/acm.2024.14123049

参考文献

[1] Zhou, H., Li, W., Pan, L., Zhu, T., Zhou, T., Xiao, E., et al. (2024) Human Extracellular Matrix (ECM)-Like Collagen and Its Bioactivity. Regenerative Biomaterials, 11, rbae008. [Google Scholar] [CrossRef] [PubMed]
[2] Liu, J., Pan, D., Huang, X., Wang, S., Chen, H., Zhu, Y.Z., et al. (2023) Targeting Collagen in Tumor Extracellular Matrix as a Novel Targeted Strategy in Cancer Immunotherapy. Frontiers in Oncology, 13, Article 1225483. [Google Scholar] [CrossRef] [PubMed]
[3] Richards, A.J. and Snead, M.P. (2022) Molecular Basis of Pathogenic Variants in the Fibrillar Collagens. Genes (Basel), 13, 1199. [Google Scholar] [CrossRef] [PubMed]
[4] Martins Cavaco, A.C., Dâmaso, S., Casimiro, S. and Costa, L. (2020) Collagen Biology Making Inroads into Prognosis and Treatment of Cancer Progression and Metastasis. Cancer and Metastasis Reviews, 39, 603-623. [Google Scholar] [CrossRef] [PubMed]
[5] Ersanli, C., Tzora, A., Skoufos, I., Voidarou, C. and Zeugolis, D.I. (2023) Recent Advances in Collagen Antimicrobial Biomaterials for Tissue Engineering Applications: A Review. International Journal of Molecular Sciences, 24, Article 7808. [Google Scholar] [CrossRef] [PubMed]
[6] Mienaltowski, M.J., Gonzales, N.L., Beall, J.M. and Pechanec, M.Y. (2021) Basic Structure, Physiology, and Biochemistry of Connective Tissues and Extracellular Matrix Collagens. In: Halper, J., Ed., Advances in Experimental Medicine and Biology, Springer International Publishing, 5-43. [Google Scholar] [CrossRef] [PubMed]
[7] 李建, 李大鹏, 赵国阳. 骨关节炎患者关节软骨中胶原蛋白表达变化的研究进展[J]. 中国骨与关志, 2020, 9(2): 148-152.
[8] Post, W.M., Widomska, J., Grens, H., Coenen, M.J.H., Martens, F.M.J., Janssen, D.A.W., et al. (2022) Molecular Processes in Stress Urinary Incontinence: A Systematic Review of Human and Animal Studies. International Journal of Molecular Sciences, 23, Article 3401. [Google Scholar] [CrossRef] [PubMed]
[9] Jia, Y., Zhou, J., Chang, Y., An, F., Li, X., Xu, X., et al. (2018) Effect of Optimized Concentrations of Basic Fibroblast Growth Factor and Epidermal Growth Factor on Proliferation of Fibroblasts and Expression of Collagen: Related to Pelvic Floor Tissue Regeneration. Chinese Medical Journal, 131, 2089-2096. [Google Scholar] [CrossRef] [PubMed]
[10] 陈锐娥, 周幸知, 丁淼, 等. 盆底功能障碍性疾病基础研究进展[J]. 国际妇产科学杂志, 2017, 44(5): 589-593.
[11] Gong, R. and Xia, Z. (2019) Collagen Changes in Pelvic Support Tissues in Women with Pelvic Organ Prolapse. European Journal of Obstetrics & Gynecology and Reproductive Biology, 234, 185-189. [Google Scholar] [CrossRef] [PubMed]
[12] Wang, X., Wang, X., Zhou, Y., Peng, C., Chen, H. and Lu, Y. (2019) Mitofusin2 Regulates the Proliferation and Function of Fibroblasts: The Possible Mechanisms Underlying Pelvic Organ Prolapse Development. Molecular Medicine Reports, 20, 2859-2866.
[13] Gong, R. and Xia, Z. (2019) Collagen Changes in Pelvic Support Tissues in Women with Pelvic Organ Prolapse. European Journal of Obstetrics & Gynecology and Reproductive Biology, 234, 185-189. [Google Scholar] [CrossRef] [PubMed]
[14] Brito, L.G.O., Pereira, G.M.V., Moalli, P., Shynlova, O., Manonai, J., Weintraub, A.Y., et al. (2021) Age and/or Postmenopausal Status as Risk Factors for Pelvic Organ Prolapse Development: Systematic Review with Meta-Analysis. International Urogynecology Journal, 33, 15-29. [Google Scholar] [CrossRef] [PubMed]
[15] Jameson, S.A., Swaminathan, G., Dahal, S., Couri, B., Kuang, M., Rietsch, A., et al. (2020) Elastin Homeostasis Is Altered with Pelvic Organ Prolapse in Cultures of Vaginal Cells from a Lysyl Oxidase‐Like 1 Knockout Mouse Model. Physiological Reports, 8, e14436. [Google Scholar] [CrossRef] [PubMed]
[16] Ryu, T.K., Lee, H., Yon, D.K., Nam, D.Y., Lee, S.Y., Shin, B.H., et al. (2022) The Antiaging Effects of a Product Containing Collagen and Ascorbic Acid: In Vitro, Ex Vivo, and Pre-Post Intervention Clinical Trial. PLOS ONE, 17, e0277188. [Google Scholar] [CrossRef] [PubMed]
[17] Pallaske, F., Pallaske, A., Herklotz, K. and Boese-Landgraf, J. (2018) The Significance of Collagen Dressings in Wound Management: A Review. Journal of Wound Care, 27, 692-702. [Google Scholar] [CrossRef] [PubMed]
[18] Liu, C. (2021) Application of Marine Collagen for Stem-Cell-Based Therapy and Tissue Regeneration (Review). Medicine International, 1, Article No. 6. [Google Scholar] [CrossRef] [PubMed]
[19] Gedikbasi, A., Yücel, B., Arslan, O., Giris, M., Gedikbasi, A. and Abbasoglu, S.D. (2015) Dynamic Collagen Changes in Cervix during the First Trimester and Decreased Collagen Content in Cervical Insufficiency. The Journal of Maternal-Fetal & Neonatal Medicine, 29, 2968-2972. [Google Scholar] [CrossRef] [PubMed]
[20] Rahn, D.D., Richter, H.E., Sung, V.W., Pruszynski, J.E. and Hynan, L.S. (2023) Perioperative Vaginal Estrogen as Adjunct to Native Tissue Vaginal Apical Prolapse Repair. JAMA, 330, 615-625. [Google Scholar] [CrossRef] [PubMed]
[21] You, S., Liu, S., Dong, X., Li, H., Zhu, Y. and Hu, L. (2020) Intravaginal Administration of Human Type III Collagen-Derived Biomaterial with High Cell-Adhesion Activity to Treat Vaginal Atrophy in Rats. ACS Biomaterials Science & Engineering, 6, 1977-1988. [Google Scholar] [CrossRef] [PubMed]
[22] 董晓静, 郭雪桃, 游爽, 等. 重组III型人源化胶原蛋白阴道凝胶治疗阴道干涩临床研究[J]. 中国实用妇科与产科杂志, 2022, 38(6): 657-660.
[23] De Rosa, N., Santangelo, F., Todisco, C., Dequerquis, F. and Santangelo, C. (2023) Collagen-Based Ovule Therapy Reduces Inflammation and Improve Cervical Epithelialization in Patients with Fungal, Viral, and Bacterial Cervico-vaginitis. Medicina, 59, Article 1490. [Google Scholar] [CrossRef] [PubMed]
[24] 王华斌, 丁勇利, 陈礼全. 压力性尿失禁患者盆底组织E-cadherin和Vimentin表达水平及临床意义[J]. 中国妇幼保健, 2020, 35(5): 928-931.
[25] Aghaei-Ghareh-Bolagh, B., Mukherjee, S., Lockley, K.M., Mithieux, S.M., Wang, Z., Emmerson, S., et al. (2020) A Novel Tropoelastin-Based Resorbable Surgical Mesh for Pelvic Organ Prolapse Repair. Materials Today Bio, 8, Article ID: 100081. [Google Scholar] [CrossRef] [PubMed]
[26] El-Hamamsy, D. and Tincello, D.G. (2020) Recurrent Stress Urinary Incontinence Surgery in the United Kingdom: An Analysis of the British Society of Urogynaecology Database (2007-2015). International Urogynecology Journal, 32, 167-172. [Google Scholar] [CrossRef] [PubMed]
[27] Myers, K., Socrate, S., Tzeranis, D. and House, M. (2009) Changes in the Biochemical Constituents and Morphologic Appearance of the Human Cervical Stroma during Pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology, 144, S82-S89. [Google Scholar] [CrossRef] [PubMed]
[28] Volozonoka, L., Rots, D., Kempa, I., Kornete, A., Rezeberga, D., Gailite, L., et al. (2020) Genetic Landscape of Preterm Birth Due to Cervical Insufficiency: Comprehensive Gene Analysis and Patient Next-Generation Sequencing Data Interpretation. PLOS ONE, 15, e0230771. [Google Scholar] [CrossRef] [PubMed]
[29] Pallaske, F., Pallaske, A., Herklotz, K. and Boese-Landgraf, J. (2018) The Significance of Collagen Dressings in Wound Management: A Review. Journal of Wound Care, 27, 692-702. [Google Scholar] [CrossRef] [PubMed]
[30] Gold, M.H. (2021) Journal of Cosmetic Dermatology—January 2022 Editorial. Journal of Cosmetic Dermatology, 21, 3. [Google Scholar] [CrossRef] [PubMed]
[31] Duteil, L., Queille-Roussel, C., Maubert, Y., Esdaile, J., Bruno-Bonnet, C. and Lacour, J. (2016) Specific Natural Bioactive Type 1 Collagen Peptides Oral Intake Reverse Skin Aging Signs in Mature Women. Journal of Aging Research and Lifestyle, 1-9. [Google Scholar] [CrossRef] 
[32] Tanveer, M.A., Rashid, H. and Tasduq, S.A. (2023) Molecular Basis of Skin Photoaging and Therapeutic Interventions by Plant-Derived Natural Product Ingredients: A Comprehensive Review. Heliyon, 9, e13580. [Google Scholar] [CrossRef] [PubMed]
[33] Oefner, C.M., Sharkey, A., Gardner, L., Critchley, H., Oyen, M. and Moffett, A. (2015) Collagen Type IV at the Fetal-Maternal Interface. Placenta, 36, 59-68. [Google Scholar] [CrossRef] [PubMed]
[34] Liu, M., Yin, Y., Yu, H. and Zhou, R. (2020) Laminins Regulate Placentation and Pre-Eclampsia: Focus on Trophoblasts and Endothelial Cells. Frontiers in Cell and Developmental Biology, 8, Article 754. [Google Scholar] [CrossRef] [PubMed]
[35] Skrzypczak, J., Wirstlein, P. and Mikolajczyk, M. (2006) Could the Defects in the Endometrial Extracellular Matrix during the Implantation Be a Cause for Impaired Fertility? American Journal of Reproductive Immunology, 57, 40-48. [Google Scholar] [CrossRef] [PubMed]
[36] Nissi, R., Talvensaari-Mattila, A., Kotila, V., Niinimäki, M., Järvelä, I. and Turpeenniemi-Hujanen, T. (2013) Circulating Matrix Metalloproteinase MMP-9 and MMP-2/TIMP-2 Complex Are Associated with Spontaneous Early Pregnancy Failure. Reproductive Biology and Endocrinology, 11, Article No. 2. [Google Scholar] [CrossRef] [PubMed]
[37] Hashiguchi, M., Takezawa, T., Nagase, K., Tayama-Abe, M., Matsuhisa, F., Kitajima, S., et al. (2021) Collagen Vitrigel Membrane-Coated Nylon Line Prevents Stenosis after Conization of the Cervix Uteri. Tissue Engineering Part A, 27, 1480-1489. [Google Scholar] [CrossRef] [PubMed]
[38] Mogami, H., Kishore, A.H. and Word, R.A. (2018) Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes. Scientific Reports, 8, Article No. 696. [Google Scholar] [CrossRef] [PubMed]
[39] Singh, B., Sims, H., Trueheart, I., et al. (2021) A Phase I Clinical Trial to Assess Safety and Tolerability of Injectable Collagenase in Women with Symptomatic Uterine Fibroids. Reproductive Sciences, 28, 2699-2709.
[40] Zhang, X., Liu, J., Yang, X., Jiao, W., Shen, C., Zhao, X., et al. (2022) High Expression of COL6A1 Predicts Poor Prognosis and Response to Immunotherapy in Bladder Cancer. Cell Cycle, 22, 610-618. [Google Scholar] [CrossRef] [PubMed]

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