维生素D在偏头痛临床治疗效果中的系统综述

A Systematic Review of the Effects of Vitamin D in the Clinical Treatment of Migraine

摘要: 目前偏头痛的研究表明，维生素D逐渐成为一种可行的治疗策略。然而，由于偏头痛的发病机制尚未完全明确，维生素D干预偏头痛的理论支持并不充分，补充维生素D能否改善偏头痛患者的临床症状仍存在争议。本研究采用RevMan5软件对1980年1月至2021年7月有关补充维生素D治疗偏头痛的研究文献进行了评估。作者使用Cochrane干预评估和NOS量表标准独立对Web of Science、Embase、Medline、PubMed和Cochrane Library进行系统检索，六项研究，共涉及389名偏头痛患者。收集的数据显示，与对照组相比，维生素D能有效降低偏头痛严重程度(P = 0.005)、偏头痛持续时间(P = 0.0004)、偏头痛天数/月(P = 0.0002)和偏头痛频率(月) (P = 0.01)。这表明维生素D的干预治疗对改善偏头痛的临床症状有良好效果。

Abstract: Currently, research on migraines suggests that vitamin D is becoming a viable treatment strategy. However, as the pathogenesis of migraine is not completely clear, the theoretical support of vitamin D intervention in migraine is not much sufficient, and it is still controversial whether vitamin D supplementation can improve the clinical symptoms of migraine patients. This systematic review evaluated the literature on studies of vitamin D supplementation for migraine using a meta-analysis from January 1980 to July 2021 using RevMan5 software. A systematic search of Web of Science, Embase, Medline, PubMed and Cochrane Library has been performed independently by the author using Cochrane intervention evaluation and NOS scale criteria. This systematic review included six studies involving 389 migraine patients. The data collected showed that: compared with the control group, vitamin D supplementation was effective in reducing migraine severity (P = 0.005), duration of migraine (P = 0.0004), migraine days/month (P = 0.0002) and migraine frequency (month) (P = 0.01). It is concluded that the intervention therapy of vitamin D supplement has a good effect on improving the clinical symptoms of migraine.