低频重复经颅磁刺激在帕金森病运动功能障碍中的研究进展
Advances in the Study of Low-Frequency Repetitive Transcranial Magnetic Stimulation in Parkinson’s Disease Motor Dysfunction
DOI: 10.12677/acm.2024.14123056, PDF,   
作者: 吕 玥, 郑宇彤:黑龙江中医药大学研究生院,黑龙江 哈尔滨;李晓宁*:黑龙江中医药大学附属第二医院,黑龙江 哈尔滨
关键词: 帕金森病低频重复经颅磁刺激运动功能障碍Parkinson’s Disease Low-Frequency Repetitive Transcranial Magnetic Stimulation Motor Dysfunction
摘要: 重复经颅磁刺激(repetitive Transcranial Magnetic Stimulation, rTMS)在神经病学生理学领域已显示出作为帕金森病(Parkinson’s disease, PD)治疗手段的应用前景,该技术为理解PD运动障碍相关的病理生理学提供了重要的见解,特别是对于在治疗PD伴有运动功能障碍症状方面有着显著的优势。本文旨在就低频rTMS改善PD运动症状的研究进展进行综述,以增强人们对低频rTMS的认识,以期应用此种技术更好地为PD临床应用提供参考。
Abstract: Repetitive Transcranial Magnetic Stimulation (rTMS) has shown promise as a treatment for Parkinson’s disease (PD) in the field of neurological pathology, and the technique provides important insights into the pathophysiology associated with movement disorders in PD, especially for the significant advantages in the treatment of PD with symptoms of motor dysfunction. The aim of this article is to review the research progress of low-frequency rTMS for improving motor symptoms in PD, in order to enhance the understanding of low-frequency rTMS, with a view to applying this technique to better inform the clinical application of PD.
文章引用:吕玥, 郑宇彤, 李晓宁. 低频重复经颅磁刺激在帕金森病运动功能障碍中的研究进展[J]. 临床医学进展, 2024, 14(12): 124-129. https://doi.org/10.12677/acm.2024.14123056

参考文献

[1] Swainson, R., Rogers, R.D., Sahakian, B.J., Summers, B.A., Polkey, C.E. and Robbins, T.W. (2000) Probabilistic Learning and Reversal Deficits in Patients with Parkinson’s Disease or Frontal or Temporal Lobe Lesions: Possible Adverse Effects of Dopaminergic Medication. Neuropsychologia, 38, 596-612. [Google Scholar] [CrossRef] [PubMed]
[2] 王学义, 陆林. 经颅磁刺激与神经精神疾病[M]. 北京: 北京大学医学出版社, 2014.
[3] Wagle Shukla, A., Shuster, J.J., Chung, J.W., Vaillancourt, D.E., Patten, C., Ostrem, J., et al. (2015) Repetitive Transcranial Magnetic Stimulation (rTMS) Therapy in Parkinson Disease: A Meta‐Analysis. PM&R, 8, 356-366. [Google Scholar] [CrossRef] [PubMed]
[4] Pascual-Leone, A., Valls-Solé, J., Brasil-Neto, J.P., Cammarota, A., Grafman, J. and Hallett, M. (1994) Akinesia in Parkinson’s Disease. II. Effects of Subthreshold Repetitive Transcranial Motor Cortex Stimulation. Neurology, 44, 892-892. [Google Scholar] [CrossRef] [PubMed]
[5] Nardone, R., De Blasi, P., Höller, Y., Christova, M., Tezzon, F., Trinka, E., et al. (2013) Repetitive Transcranial Magnetic Stimulation Transiently Reduces Punding in Parkinson’s Disease: A Preliminary Study. Journal of Neural Transmission, 121, 267-274. [Google Scholar] [CrossRef] [PubMed]
[6] Mitra Papen, Mirabell Fisse, Anna-Sophia Sarfeld, Gereon R. Fink, Dennis A. Nowak. (2014) The Effects of 1 Hz rTMS Preconditioned by tDCS on Gait Kinematics in Parkinson’s Disease. Journal of Neural Transmission, 121, 743-754. [Google Scholar] [CrossRef] [PubMed]
[7] Shah, B.B., Chen, R., Zurowski, M., Kalia, L.V., Gunraj, C. and Lang, A.E. (2015) Repetitive Transcranial Magnetic Stimulation Plus Standardized Suggestion of Benefit for Functional Movement Disorders: An Open Label Case Series. Parkinsonism & Related Disorders, 21, 407-412. [Google Scholar] [CrossRef] [PubMed]
[8] Li, S., Jiao, R., Zhou, X. and Chen, S. (2020) Motor Recovery and Antidepressant Effects of Repetitive Transcranial Magnetic Stimulation on Parkinson Disease: A PRISMA-Compliant Meta-Analysis. Medicine, 99, e19642. [Google Scholar] [CrossRef] [PubMed]
[9] Chen, Z., Li, G. and Liu, J. (2020) Autonomic Dysfunction in Parkinson’s Disease: Implications for Pathophysiology, Diagnosis, and Treatment. Neurobiology of Disease, 134, Article 104700. [Google Scholar] [CrossRef] [PubMed]
[10] Nutt, J.G., Obeso, J.A. and Stocchi, F. (2000) Continuous Dopamine-Receptor Stimulation in Advanced Parkinson’s Disease. Trends in Neurosciences, 23, S109-S115. [Google Scholar] [CrossRef] [PubMed]
[11] Meder, D., Herz, D.M., Rowe, J.B., Lehéricy, S. and Siebner, H.R. (2019) The Role of Dopamine in the Brain—Lessons Learned from Parkinson’s Disease. NeuroImage, 190, 79-93. [Google Scholar] [CrossRef] [PubMed]
[12] 何敏, 蒋玲霞, 刘志强, 等.不同频率重复经颅磁刺激治疗帕金森病剂峰异动症的临床研究[J]. 江西医药, 2023, 58(10): 1157-1161.
[13] Skrabal, D., Rusz, J., Novotny, M., Sonka, K., Ruzicka, E., Dusek, P., et al. (2022) Articulatory Undershoot of Vowels in Isolated REM Sleep Behavior Disorder and Early Parkinson’s Disease. npj Parkinsons Disease, 8, Article No. 137. [Google Scholar] [CrossRef] [PubMed]
[14] Rusz, J., Hlavnička, J., Novotný, M., Tykalová, T., Pelletier, A., Montplaisir, J., et al. (2021) Speech Biomarkers in Rapid Eye Movement Sleep Behavior Disorder and Parkinson Disease. Annals of Neurology, 90, 62-75. [Google Scholar] [CrossRef] [PubMed]
[15] Silbergleit, A.K., Schultz, L., Hamilton, K., LeWitt, P.A. and Sidiropoulos, C. (2021) Self-Perception of Voice and Swallowing Handicap in Parkinson’s Disease. Journal of Parkinsons Disease, 11, 2027-2034. [Google Scholar] [CrossRef] [PubMed]
[16] Eickhoff, S.B., Heim, S., Zilles, K. and Amunts, K. (2009) A Systems Perspective on the Effective Connectivity of Overt Speech Production. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 367, 2399-2421. [Google Scholar] [CrossRef] [PubMed]
[17] Brown, S., Laird, A.R., Pfordresher, P.Q., Thelen, S.M., Turkeltaub, P. and Liotti, M. (2009) The Somatotopy of Speech: Phonation and Articulation in the Human Motor Cortex. Brain and Cognition, 70, 31-41. [Google Scholar] [CrossRef] [PubMed]
[18] Pinto, S., Thobois, S., Costes, N., Le Bars, D., Benabid, A., Broussolle, E., et al. (2004) Subthalamic Nucleus Stimulation and Dysarthria in Parkinson’s Disease: A PET Study. Brain, 127, 602-615. [Google Scholar] [CrossRef] [PubMed]
[19] Liotti, M., Ramig, L.O., Vogel, D., New, P., Cook, C.I., Ingham, R.J., et al. (2003) Hypophonia in Parkinson’s Disease: Neural Correlates of Voice Treatment Revealed by PET. Neurology, 60, 432-440. [Google Scholar] [CrossRef] [PubMed]
[20] Ho, A.K., Iansek, R., Marigliani, C., Bradshaw, J.L. and Gates, S. (1999) Speech Impairment in a Large Sample of Patients with Parkinson’s Disease. Behavioural Neurology, 11, 131-137. [Google Scholar] [CrossRef] [PubMed]
[21] Brabenec, L., Mekyska, J., Galaz, Z. and Rektorova, I. (2017) Speech Disorders in Parkinson’s Disease: Early Diagnostics and Effects of Medication and Brain Stimulation. Journal of Neural Transmission, 124, 303-334. [Google Scholar] [CrossRef] [PubMed]
[22] Brabenec, L., Klobusiakova, P., Simko, P., Kostalova, M., Mekyska, J. and Rektorova, I. (2021) Non-Invasive Brain Stimulation for Speech in Parkinson’s Disease: A Randomized Controlled Trial. Brain Stimulation, 14, 571-578. [Google Scholar] [CrossRef] [PubMed]
[23] Moreau, C. and Pinto, S. (2019) Misconceptions about Speech Impairment in Parkinson’s Disease. Movement Disorders, 34, 1471-1475. [Google Scholar] [CrossRef] [PubMed]
[24] Frühholz, S., Gschwind, M. and Grandjean, D. (2015) Bilateral Dorsal and Ventral Fiber Pathways for the Processing of Affective Prosody Identified by Probabilistic Fiber Tracking. NeuroImage, 109, 27-34. [Google Scholar] [CrossRef] [PubMed]
[25] Guo, Z., Huang, X., Wang, M., Jones, J.A., Dai, Z., Li, W., et al. (2016) Regional Homogeneity of Intrinsic Brain Activity Correlates with Auditory-Motor Processing of Vocal Pitch Errors. NeuroImage, 142, 565-575. [Google Scholar] [CrossRef] [PubMed]
[26] Rektorova, I., Barrett, J., Mikl, M., Rektor, I. and Paus, T. (2007) Functional Abnormalities in the Primary Orofacial Sensorimotor Cortex during Speech in Parkinson’s Disease. Movement Disorders, 22, 2043-2051. [Google Scholar] [CrossRef] [PubMed]
[27] Mirelman, A., Bonato, P., Camicioli, R., Ellis, T.D., Giladi, N., Hamilton, J.L., et al. (2019) Gait Impairments in Parkinson’s Disease. The Lancet Neurology, 18, 697-708. [Google Scholar] [CrossRef] [PubMed]
[28] Nutt, J.G., Bloem, B.R., Giladi, N., Hallett, M., Horak, F.B. and Nieuwboer, A. (2011) Freezing of Gait: Moving Forward on a Mysterious Clinical Phenomenon. The Lancet Neurology, 10, 734-744. [Google Scholar] [CrossRef] [PubMed]
[29] Brooks, V.B. and Stoney, S.D. (1971) Motor Mechanisms: The Role of the Pyramidal System in Motor Control. Annual Review of Physiology, 33, 337-388. [Google Scholar] [CrossRef] [PubMed]
[30] 曾志童, 黄鹏, 孙伯民, 等. 帕金森病步态障碍的侵入性神经调控治疗进展[J]. 重庆医科大学学报, 2024, 49(5): 548-551.
[31] Lefaucheur, J., André-Obadia, N., Antal, A., Ayache, S.S., Baeken, C., Benninger, D.H., et al. (2014) Evidence-Based Guidelines on the Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS). Clinical Neurophysiology, 125, 2150-2206. [Google Scholar] [CrossRef] [PubMed]
[32] 赵澎, 程焱, 陶华英, 等. 重复经颅磁刺激对帕金森病运动功能及运动诱发电位的影响[J]. 中国临床神经科学, 2007, 15(4): 397-401.
[33] Hemsley, K.M., Farrall, E.J. and Crocker, A.D. (2002) Dopamine Receptors in the Subthalamic Nucleus Are Involved in the Regulation of Muscle Tone in the Rat. Neuroscience Letters, 317, 123-126. [Google Scholar] [CrossRef] [PubMed]
[34] Zhuang, S., Wang, F., Gu, X., Wu, J., Mao, C., Gui, H., et al. (2020) Low-Frequency Repetitive Transcranial Magnetic Stimulation Over Right Dorsolateral Prefrontal Cortex in Parkinson’s Disease. Parkinsons Disease, 2020, Article 7295414. [Google Scholar] [CrossRef] [PubMed]