高尿酸血症与冠状动脉粥样硬化关系的研究进展
Research Progress on the Relationship between Hyperuricemia and Coronary Atherosclerosis
DOI: 10.12677/acm.2024.14123064, PDF,   
作者: 吴 畏, 郭 鹏*：北华大学附属医院肾病风湿病科，吉林 吉林
关键词: 高尿酸血症；冠状动脉粥样硬化；Hyperuricemia； Coronary Atherosclerosis
摘要: 高尿酸血症(Hyperuricemia, HUA)是近二十年来一种临床常见的代谢性疾病。冠状动脉粥样硬化(Coronary Atherosclerosis)本质上就是脂质沉积于血管内膜下而导致的冠脉慢性炎症性疾病。近年来研究发现临床上冠状动脉粥样硬化患者多伴有HUA的发生，因此HUA对冠状动脉粥样硬化的影响逐渐受到关注。目前的研究学说包括：氧化应激学说、结晶析出学说、NO抑制学说、纤溶系统激活及血小板粘附学说等总结出的血管内皮功能障碍学说。因此，本文将针对高尿酸血症与冠状动脉粥样硬化之间关系的目前的研究进展进行综述。
Abstract: Hyperuricemia (HUA) is a common metabolic disease in clinical practice in the past two decades. Coronary atherosclerosis is essentially a chronic inflammatory disease of coronary arteries caused by lipid deposition under the intima of blood vessels. In recent years, studies have found that most patients with coronary atherosclerosis are accompanied by the occurrence of HUA, so the impact of HUA on coronary atherosclerosis has gradually attracted attention. The current research theories include oxidative stress theory, crystallization precipitation theory, NO inhibition theory, fibrinolytic system activation and platelet adhesion theory, which summarize the theory of vascular endothelial dysfunction. Therefore, this article will review the current research progress on the relationship between hyperuricemia and coronary atherosclerosis.
文章引用：吴畏, 郭鹏. 高尿酸血症与冠状动脉粥样硬化关系的研究进展[J]. 临床医学进展, 2024, 14(12): 182-188. https://doi.org/10.12677/acm.2024.14123064

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