中性粒细胞/淋巴细胞比值在类风湿关节炎中的研究进展
Research Progress of Neutrophil/Lymphocyte Ratio in Rheumatoid Arthritis
DOI: 10.12677/md.2024.144055, PDF,    科研立项经费支持
作者: 李一鸣, 徐小虎, 代义龙：济宁医学院临床医学院，山东 济宁；济宁医学院附属医院检验科，山东 济宁；金呈强*：济宁医学院附属医院检验科，山东 济宁
关键词: 中性粒细胞；淋巴细胞比值；类风湿关节炎；预后；Neutrophil； Lymphocyte Ratio； Rheumatoid Arthritis； Prognosis
摘要: 中性粒细胞/淋巴细胞比值(NLR)是一种新型非特异性炎症指标，其通过测定外周血中的中性粒细胞和淋巴细胞的计数比值来评估机体的免疫状态。目前被用于各种良恶性肿瘤、心血管疾病、感染性疾病和免疫系统疾病的早期诊断和预后监测。而类风湿关节炎(RA)是第二常见的慢性关节炎性疾病，以对称性侵袭性关节、滑膜炎症为主。作为高致残性的疾病，类风湿性关节炎的早期诊断、病情监测对于患者的预后结局有着重要作用。临床中对于疾病的监测涉及多种生物标记物，其中本文就NLR在RA中的作用进行综述，以期为炎症指标在RA中的价值提供新的见解。
Abstract: The neutrophil-to-lymphocyte ratio (NLR) is an emerging non-specific inflammatory biomarker that assesses the immune status of an individual by calculating the ratio of neutrophils to lymphocytes in peripheral blood. It is currently utilized for the early diagnosis and prognostic monitoring of a spectrum of benign and malignant tumors, cardiovascular diseases, infectious diseases, and immune system disorders. Rheumatoid arthritis (RA), the second most common chronic articular disease, is characterized primarily by symmetrical invasive joints and synovial inflammation. As a highly disabling condition, early diagnosis and disease monitoring of RA play a crucial role in determining the patient’s prognostic outcome. In clinical practice, disease monitoring encompasses a variety of biological markers. This review focuses on the role of NLR in RA, aiming to provide new insights into the value of inflammatory markers in the context of RA.
文章引用：李一鸣, 徐小虎, 代义龙, 金呈强. 中性粒细胞/淋巴细胞比值在类风湿关节炎中的研究进展[J]. 医学诊断, 2024, 14(4): 381-387. https://doi.org/10.12677/md.2024.144055

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