2型糖尿病从“肝脾论治”的思路探讨
Exploration of the Therapeutic Approach for Type 2 Diabetes Mellitus Based on the “Liver and Spleen Theory”
DOI: 10.12677/jcpm.2024.34208, PDF,   
作者: 吴艺高, 马国庆*:黑龙江中医药大学附属第二医院内分泌科,黑龙江 哈尔滨
关键词: 2型糖尿病胰岛素抵抗胰岛素肝脾Type 2 Diabetes Mellitus Insulin Resistance Insulin Liver and Spleen
摘要: 在2型糖尿病(Type 2 diabetes mellitus, T2DM)传统的辨证施治体系中,三消辨证法最为详尽,其核心多围绕阴虚燥热之病机,归咎于肺、胃、肾三脏的功能失调。然而,仅依据“三消”理论进行论治已难以满足当前临床治疗的实际需求,鉴于此,众多医家勇于突破传统“三消”框架,当融合脏腑定位与气血阴阳的精细辨证,以分型施治。本文深入探讨了肝脾两脏与T2DM发病机制的内在联系,为基于“肝脾”理论治疗T2DM奠定了坚实的理论基础。
Abstract: In the traditional system of diagnosis and treatment of thirst-quenching disease, the three elimination method is the most detailed, the core of which is centered around the disease mechanism of Yin deficiency and dryness and heat, attributed to the dysfunction of the lungs, stomach and kidneys. However, it is difficult to meet the actual needs of current clinical treatment only based on the theory of “three eliminations”. In view of this, many medical practitioners have the courage to break through the traditional framework of “three eliminations” when integrating the positioning of internal organs and the fine identification of qi, blood, yin and yang, in order to differentiate and administer the treatment. In this paper, the intrinsic connection between the liver and spleen and the pathogenesis of type 2 diabetes mellitus (T2DM) is discussed in depth, which lays a solid theoretical foundation for the treatment of type 2 diabetes mellitus based on the theory of liver and spleen.
文章引用:吴艺高, 马国庆. 2型糖尿病从“肝脾论治”的思路探讨[J]. 临床个性化医学, 2024, 3(4): 1464-1468. https://doi.org/10.12677/jcpm.2024.34208

参考文献

[1] Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurtsova, K., Duncan, B.B., et al. (2022) IDF Diabetes Atlas: Global, Regional and Country-Level Diabetes Prevalence Estimates for 2021 and Projections for 2045. Diabetes Research and Clinical Practice, 183, Article ID: 109119. [Google Scholar] [CrossRef] [PubMed]
[2] 赵进喜, 冯兴中, 仝小林, 等. 论糖尿病的中医核心病机与基本治法[J]. 北京中医药, 2019, 38(1): 3-6.
[3] 周莹, 刘军彤, 宁顺宇, 等. 从脾论治2型糖尿病研究进展[J]. 辽宁中医药大学学报, 2023, 25(8): 93-98.
[4] 何莉莎, 顾成娟, 崔亚珊, 等. 仝小林教授从“土壅木郁”辨治代谢综合征经验[J]. 世界中医药, 2015, 10(12): 1914-1917.
[5] 孙宁远, 朱雪林, 陈君. 丹参化学成分抗纤维化药理作用及机制研究进展[J]. 中国实验方剂学杂志, 2020, 26(22): 201-208.
[6] King, G.L., Park, K. and Li, Q. (2016) Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture. Diabetes, 65, 1462-1471. [Google Scholar] [CrossRef] [PubMed]
[7] Long, H., Cheng, Y., Zhou, Z., Luo, H., Wen, D. and Gao, L. (2021) PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease. Frontiers in Pharmacology, 12, Article ID: 648636. [Google Scholar] [CrossRef] [PubMed]
[8] 师林, 柯斌. 2型糖尿病胰岛素抵抗的脾虚本质探讨[J]. 中华中医药学刊, 2015, 33(6): 1346-1348.
[9] Blüher, M. (2014) Adipokines—Removing Road Blocks to Obesity and Diabetes Therapy. Molecular Metabolism, 3, 230-240. [Google Scholar] [CrossRef] [PubMed]
[10] 孙宁宁, 叶永安. “土壅木郁”理论及其在肝病临床中的应用[J]. 世界中医药, 2015, 10(3): 383-386.
[11] 张杰文, 林靖, 季兵. 从肝脾论治糖尿病伴抑郁障碍[J]. 中医临床研究, 2022, 14(23): 72-74.
[12] 张琪, 杜顺棠, 季兵, 等. 四逆散合甘麦大枣汤治疗2型糖尿病合并抑郁焦虑状态临床观察[J]. 广州中医药大学学报, 2022, 39(4): 763-769.
[13] 沈桂祥. 浅谈脾胰同源[J]. 中医杂志, 2009, 50(12): 1141-1142.
[14] 金旭, 肖万泽. 再论中医脾与糖尿病[J]. 中国民间疗法, 2021, 29(5): 1-3.
[15] 周明阳, 杨兰, 富晓旭, 等. 血糖变化与中医升降出入理论的关系[J]. 中医杂志, 2017, 58(18): 1612-1613, 1620.
[16] 杨帆, 黄江荣, 向楠. 肝脾肾功能失调与胰岛素抵抗的关系探讨[J]. 时珍国医国药, 2009, 20(6): 1556-1557.
[17] 吴倩, 倪青. 糖尿病肝脾失和病机与四逆散现代新用[J]. 中国中医基础医学杂志, 2022, 28(5): 701-703.
[18] 依秋霞, 张泽. 李敬林学术思想传承——重视情志, 从肝论治消渴[J]. 辽宁中医杂志, 2017, 44(4): 699-701.
[19] 郦安琪, 柴可夫, 邱蓉, 等. “脾虚”和“肝郁”在糖尿病发病中的作用[J]. 中华中医药学刊, 2013, 31(9): 1994-1996.