铁死亡调控机制及与心力衰竭研究进展
Mechanisms of Ferroptosis Regulation and Progress with Heart Failure Research
DOI: 10.12677/jcpm.2024.34210, PDF,   
作者: 程 旭：内蒙古民族大学临床医学院，内蒙古 通辽；陈少青*：内蒙古民族大学附属医院心血管内科，内蒙古 通辽
关键词: 铁死亡；心力衰竭；脂质过氧化；Ferroptosis； Heart Failure； Lipid Peroxidation
摘要: 铁死亡(Ferroptosis)是一种新型程序性死亡模式，主要由铁依赖的脂质过氧化和铁离子聚集引起。心力衰竭是一种严重危害人类健康的重大疾病，其发病率和死亡率在全球范围内持续升高。最新研究表明，铁死亡是心衰的关键环节。铁死亡与心衰之间的相关性已成为当前研究的热点。本文对铁代谢调节的机制及其与心力衰竭的关系进行综述。
Abstract: Ferroptosis is a novel mode of programmed death caused mainly by iron-dependent lipid peroxidation and iron ion aggregation. Heart failure is a major disease that seriously jeopardizes human health, and its morbidity and mortality continue to increase worldwide. Recent studies have shown that ferroptosis is a key component of heart failure. The correlation between ferroptosis and heart failure has become a hot topic of current research. In this paper, we review the mechanisms of iron metabolism regulation and its relationship with heart failure.
文章引用：程旭, 陈少青. 铁死亡调控机制及与心力衰竭研究进展[J]. 临床个性化医学, 2024, 3(4): 1473-1478. https://doi.org/10.12677/jcpm.2024.34210

参考文献

[1] 张梦雪, 王小钦. 铁稳态失调相关的炎症性贫血发病机制及诊断进展[J]. 诊断学理论与实践, 2018, 17(5): 601-605.
[2] Dixon, S.J., Lemberg, K.M., Lamprecht, M.R., Skouta, R., Zaitsev, E.M., Gleason, C.E., et al. (2012) Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death. Cell, 149, 1060-1072. [Google Scholar] [CrossRef] [PubMed]
[3] 郭婕, 王玉龙, 麦凤怡, 等. 铁自噬介导铁死亡机制和检测方法的研究进展[J]. 中国病理生理杂志, 2024, 40(2): 365-374.
[4] 周晗, 贺海波, 张继红. 心力衰竭与铁死亡的机制研究及中医药治疗进展[J]. 中国中医药现代远程教育, 2024, 22(9): 79-81.
[5] Golej, D.L., Askari, B., Kramer, F., Barnhart, S., Vivekanandan-Giri, A., Pennathur, S., et al. (2011) Long-Chain Acyl-Coa Synthetase 4 Modulates Prostaglandin E2 Release from Human Arterial Smooth Muscle Cells. Journal of Lipid Research, 52, 782-793. [Google Scholar] [CrossRef] [PubMed]
[6] Zhang, H., Hu, B., Li, Z., Du, T., Shan, J., Ye, Z., et al. (2022) PKCβII Phosphorylates ACSL4 to Amplify Lipid Peroxidation to Induce Ferroptosis. Nature Cell Biology, 24, 88-98. [Google Scholar] [CrossRef] [PubMed]
[7] Ren, J., Privratsky, J.R., Yang, X., et al. (2023) Metallothionein Alleviates Glutathione Depletion-Induced Oxidative Cardiomyopathy in Murine Hearts: Retraction. Critical Care Medicine, 51, e92.
[8] Li, W., Liang, L., Liu, S., Yi, H. and Zhou, Y. (2023) FSP1: A Key Regulator of Ferroptosis. Trends in Molecular Medicine, 29, 753-764. [Google Scholar] [CrossRef] [PubMed]
[9] 袁静, 王海燕, 邢永华, 等. 基于铁死亡调控的癌症治疗研究进展[J]. 实用肿瘤杂志, 2023, 38(1): 73-79.
[10] Mao, C., Liu, X., Zhang, Y., Lei, G., Yan, Y., Lee, H., et al. (2021) DHODH-Mediated Ferroptosis Defence Is a Targetable Vulnerability in Cancer. Nature, 593, 586-590. [Google Scholar] [CrossRef] [PubMed]
[11] Yang, X., Huang, T., Chen, Y., Chen, F., Liu, Y., Wang, Y., et al. (2023) Deoxynivalenol Induces Testicular Ferroptosis by Regulating the Nrf2/System Xc−/GPX4 Axis. Food and Chemical Toxicology, 175, Article ID: 113730. [Google Scholar] [CrossRef] [PubMed]
[12] Yu, H., Yang, C., Jian, L., Guo, S., Chen, R., Li, K., et al. (2019) Sulfasalazine-Induced Ferroptosis in Breast Cancer Cells Is Reduced by the Inhibitory Effect of Estrogen Receptor on the Transferrin Receptor. Oncology Reports, 42, 826-838. [Google Scholar] [CrossRef] [PubMed]
[13] Savarese, G., Becher, P.M., Lund, L.H., Seferovic, P., Rosano, G.M.C. and Coats, A.J.S. (2022) Global Burden of Heart Failure: A Comprehensive and Updated Review of Epidemiology. Cardiovascular Research, 118, 3272-3287. [Google Scholar] [CrossRef] [PubMed]
[14] Wang, H., Chai, K., Du, M., Wang, S., Cai, J., Li, Y., et al. (2021) Prevalence and Incidence of Heart Failure among Urban Patients in China: A National Population-Based Analysis. Circulation: Heart Failure, 14, e008406. [Google Scholar] [CrossRef] [PubMed]
[15] 周函. 亚硝基铁硫簇合物在抗肿瘤血管治疗中的研究[D]: [硕士学位论文]. 上海: 上海师范大学, 2021.
[16] Fan, Z., Cai, L., Wang, S., Wang, J. and Chen, B. (2021) Baicalin Prevents Myocardial Ischemia/Reperfusion Injury through Inhibiting ACSL4 Mediated Ferroptosis. Frontiers in Pharmacology, 12, Article ID: 628988. [Google Scholar] [CrossRef] [PubMed]
[17] 刘清波. 白藜芦醇与成纤维细胞生长因子1协同改善阿霉素诱导急性心脏毒性的保护作用及其机制研究[D]: [硕士学位论文]. 济南: 山东大学, 2023.
[18] Chen, Y., Li, X., Wang, S., Miao, R. and Zhong, J. (2023) Targeting Iron Metabolism and Ferroptosis as Novel Therapeutic Approaches in Cardiovascular Diseases. Nutrients, 15, Article No. 591. [Google Scholar] [CrossRef] [PubMed]
[19] Stockwell, B.R., Friedmann Angeli, J.P., Bayir, H., Bush, A.I., Conrad, M., Dixon, S.J., et al. (2017) Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell, 171, 273-285. [Google Scholar] [CrossRef] [PubMed]
[20] Li, W., Feng, G., Gauthier, J.M., Lokshina, I., Higashikubo, R., Evans, S., et al. (2019) Ferroptotic Cell Death and TLR4/Trif Signaling Initiate Neutrophil Recruitment after Heart Transplantation. Journal of Clinical Investigation, 129, 2293-2304. [Google Scholar] [CrossRef] [PubMed]
[21] Yang, X., Kawasaki, N.K., Min, J., Matsui, T. and Wang, F. (2022) Ferroptosis in Heart Failure. Journal of Molecular and Cellular Cardiology, 173, 141-153. [Google Scholar] [CrossRef] [PubMed]
[22] 吴楠, 杨涛, 胡玉原, 等. 铁稳态、铁死亡与心血管疾病[J]. 临床与病理杂志, 2024, 44(2): 295-306.