皮肤损害为首发症状的淋巴瘤1例
One Case of Lymphoma with Skin Lesion as the First Symptom
DOI: 10.12677/jcpm.2024.34212, PDF,    科研立项经费支持
作者: 段爽爽：济宁医学院临床医学院，山东 济宁；济宁市第一人民医院血液内科，山东 济宁；韩净净：济宁市第一人民医院血液内科，山东 济宁；辛春雷*：济宁市第一人民医院血液内科，山东 济宁；英吉沙县人民医院，新疆 喀什
关键词: NK/T细胞淋巴瘤；皮肤损害；治疗；NK/T Cell Lymphoma； Skin Lesion； Treatment
摘要: 目的：通过1例以皮肤损害为首发症状的结外NK/T细胞淋巴瘤的病例，探讨该病例诊治线索及治疗时机。方法：回顾性分析我院1例皮肤损害为首发症状的结外NK/T细胞淋巴瘤临床表现、诊治思路、治疗结局，并进行相关文献复习。结果：该例患者因肿瘤转移合并感染，最终自动出院。结论：以皮肤损害为首发症状的结外NK/T细胞淋巴瘤患者的早期诊断及治疗十分重要。
Abstract: Objective: A case of extranodal NK/T cell lymphoma with skin lesion as the first symptom was studied to explore the clues of diagnosis and treatment and the opportunity of treatment. Methods: The clinical manifestations, diagnosis and treatment ideas, and treatment outcome of 1 case of extranodal NK/T cell lymphoma with skin lesion as the first symptom in our hospital were retrospectively analyzed, and the relevant literature was reviewed. Results: The patient was discharged automatically due to tumor metastasis and infection. Conclusions: Early diagnosis and treatment of extranodal NK/T cell lymphoma with skin lesion as the first symptom are very important.
文章引用：段爽爽, 韩净净, 辛春雷. 皮肤损害为首发症状的淋巴瘤1例[J]. 临床个性化医学, 2024, 3(4): 1483-1489. https://doi.org/10.12677/jcpm.2024.34212

参考文献

[1] Tse, E., Fox, C.P., Glover, A., Yoon, S.E., Kim, W.S. and Kwong, Y. (2022) Extranodal Natural Killer/T-Cell Lymphoma: An Overview on Pathology and Clinical Management. Seminars in Hematology, 59, 198-209. [Google Scholar] [CrossRef] [PubMed]
[2] Assaf, C., Gellrich, S., Whittaker, S., Robson, A., Cerroni, L., Massone, C., et al. (2006) CD56-Positive Haematological Neoplasms of the Skin: A Multicentre Study of the Cutaneous Lymphoma Project Group of the European Organisation for Research and Treatment of Cancer. Journal of Clinical Pathology, 60, 981-989. [Google Scholar] [CrossRef] [PubMed]
[3] Ngamdamrongkiat, P., Sukpanichnant, S., Chairatchaneeboon, M., Khuhapinant, A. and Sitthinamsuwan, P. (2022) Cutaneous Involvement of Extranodal NK/T Cell Lymphoma, Nasal Type, a Clinical and Histopathological Mimicker of Various Skin Diseases. Dermatopathology, 9, 307-320. [Google Scholar] [CrossRef] [PubMed]
[4] Brice, P., de Kerviler, E. and Friedberg, J.W. (2021) Classical Hodgkin Lymphoma. The Lancet, 398, 1518-1527. [Google Scholar] [CrossRef] [PubMed]
[5] Ansell, S.M. (2022) Hodgkin Lymphoma: 2023 Update on Diagnosis, Risk‐stratification, and Management. American Journal of Hematology, 97, 1478-1488. [Google Scholar] [CrossRef] [PubMed]
[6] Ansell, S.M. (2020) Hodgkin Lymphoma: A 2020 Update on Diagnosis, Risk‐Stratification, and Management. American Journal of Hematology, 95, 978-989. [Google Scholar] [CrossRef] [PubMed]
[7] Thandra, K.C., Barsouk, A., Saginala, K., Padala, S.A., Barsouk, A. and Rawla, P. (2021) Epidemiology of Non-Hodgkin’s Lymphoma. Medical Sciences, 9, Article 5. [Google Scholar] [CrossRef] [PubMed]
[8] Zanoni, L., Bezzi, D., Nanni, C., Paccagnella, A., Farina, A., Broccoli, A., et al. (2023) PET/CT in Non-Hodgkin Lymphoma: An Update. Seminars in Nuclear Medicine, 53, 320-351. [Google Scholar] [CrossRef] [PubMed]
[9] Syrykh, C., Péricart, S., Lamaison, C., Escudié, F., Brousset, P. and Laurent, C. (2021) Epstein-Barr Virus-Associated T-and NK-Cell Lymphoproliferative Diseases: A Review of Clinical and Pathological Features. Cancers, 13, Article 3315. [Google Scholar] [CrossRef] [PubMed]
[10] Wang, H., Fu, B., Gale, R.P. and Liang, Y. (2021) NK-/T-Cell Lymphomas. Leukemia, 35, 2460-2468. [Google Scholar] [CrossRef] [PubMed]
[11] Lungu, M., Telehuz, A., Voinescu, D., Sapira, V., Trifan, A., Elkan, E., et al. (2020) NK/T-Cell Non-Hodgkin Lymphoma: Case Report and Review of the Literature. Experimental and Therapeutic Medicine, 21, Article No. 91. [Google Scholar] [CrossRef] [PubMed]
[12] Chávez Dávila, Y.N., Pinos León, V.H., Tello Astudillo, S., Loza Erazo, G.M. and Granizo Rubio, J.D. (2023) Extranodal NK/T-Cell Lymphoma, Nasal Type, Extranasal and Ulcerative Blister Variant, Case Report. Annals of Dermatology, 35, S304. [Google Scholar] [CrossRef] [PubMed]
[13] 赵玉苗, 熊雅俊, 高景, 等. 原发性皮肤NK/T细胞淋巴瘤25例临床分析[J]. 郑州大学学报(医学版), 2023, 58(6): 811-815.
[14] 陈腊梅, 孟云芳, 宋亚丽, 等. 结外皮肤NK/T细胞淋巴瘤一例[J]. 中国麻风皮肤病杂志, 2021, 37(9): 588-590.
[15] Zuriel, D., Fink-Puches, R. and Cerroni, L. (2012) A Case of Primary Cutaneous Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type, with a 22-Year Indolent Clinical Course. The American Journal of Dermatopathology, 34, 194-197. [Google Scholar] [CrossRef] [PubMed]
[16] Akbar, M., Clasen-Linde, E. and Specht, L. (2020) Extranodal NK/T-Cell Lymphoma, Nasal Type, with Extranasal Presentation—A Case Report and a Review of the Literature. Acta Oncologica, 59, 1480-1487. [Google Scholar] [CrossRef] [PubMed]
[17] 袁芳草, 吴然, 孙少勤, 等. 以皮肤损害为首发表现的结外NK/T细胞淋巴瘤1例[J]. 临床皮肤科杂志, 2023, 52(10): 615-617.
[18] 王金容, 王丽芬, 林燕, 等. 以皮肤损害为首发症状的结外NK/T细胞淋巴瘤1例[J]. 临床皮肤科杂志, 2021, 50(11): 686-687.
[19] 王素芬, 刘萍, 卢林明, 等. 鼻型结外NK/T细胞淋巴瘤临床病理分析[J]. 临床与实验病理学杂志, 2020, 36(5): 529-533.
[20] de Oliveira Costa, R., Pereira, J., de Pádua Covas Lage, L.A. and Baiocchi, O.C.G. (2023) Extranodal NK-/T-Cell Lymphoma, Nasal Type: What Advances Have Been Made in the Last Decade? Frontiers in Oncology, 13, Article 1175545. [Google Scholar] [CrossRef] [PubMed]
[21] Sánchez-Romero, C., Bologna-Molina, R., Paes de Almeida, O., Santos-Silva, A.R., Prado-Ribeiro, A.C., Brandão, T.B., et al. (2021) Extranodal NK/T Cell Lymphoma, Nasal Type: An Updated Overview. Critical Reviews in Oncology/Hematology, 159, Article 103237. [Google Scholar] [CrossRef] [PubMed]
[22] de Leval, L., Feldman, A.L., Pileri, S., Nakamura, S. and Gaulard, P. (2022) Extranodal T-and NK-Cell Lymphomas. Virchows Archiv, 482, 245-264. [Google Scholar] [CrossRef] [PubMed]
[23] Yan, Z., Yao, S., Wang, Z., Zhou, W., Yao, Z. and Liu, Y. (2023) Treatment of Extranodal NK/T-Cell Lymphoma: From Past to Future. Frontiers in Immunology, 14, Article 1088685. [Google Scholar] [CrossRef] [PubMed]
[24] Tse, E., Zhao, W., Xiong, J. and Kwong, Y. (2022) How We Treat NK/T-Cell Lymphomas. Journal of Hematology & Oncology, 15, Article No. 74. [Google Scholar] [CrossRef] [PubMed]
[25] Qi, S., Li, Y., Specht, L., Oguchi, M., Tsang, R., Ng, A., et al. (2021) Modern Radiation Therapy for Extranodal Nasal-Type NK/T-Cell Lymphoma: Risk-Adapted Therapy, Target Volume, and Dose Guidelines from the International Lymphoma Radiation Oncology Group. International Journal of Radiation Oncology∙Biology∙Physics, 110, 1064-1081. [Google Scholar] [CrossRef] [PubMed]
[26] Terro, K., Sharrouf, L. and El Cheikh, J. (2022) Progress of Hematopoietic Stem Cell Transplantation and Radiotherapy in the Treatment of Extranodal NK/T Cell Lymphoma. Frontiers in Oncology, 12, Article 832428. [Google Scholar] [CrossRef] [PubMed]
[27] 赵怡宁, 陶丽菊. 结外NK/T细胞淋巴瘤治疗进展[J]. 右江医学, 2020, 48(9): 706-709.
[28] 刘琼. 皮肤结外NK/T细胞淋巴瘤临床特点分析[D]: [硕士学位论文]. 芜湖: 皖南医学院, 2022.
[29] Wang, L., Li, L., Zhang, L. and Wang, J. (2020) The Landscape of New Drugs in Extranodal NK/T-Cell Lymphoma. Cancer Treatment Reviews, 89, Article 102065. [Google Scholar] [CrossRef] [PubMed]
[30] 吴倩. 结外NK/T细胞淋巴瘤的治疗进展[D]: [硕士学位论文]. 重庆: 重庆医科大学, 2020.
[31] 张时全, 郝春成, 葛晓峰. 结外鼻型NK/T细胞淋巴瘤的临床病理特征及诊疗现状[J]. 现代肿瘤医学, 2022, 30(12): 2275-2280.
[32] Jeong, S.H. (2020) Extranodal NK/T Cell Lymphoma. BLOOD RESEARCH, 55, S63-S71. [Google Scholar] [CrossRef] [PubMed]
[33] Yi, W., Yang, T., Lin, S., Hao, R., Yu, J., Wang, Y., et al. (2022) New Approaches for Treatment of Advanced Extranodal NK/T-Cell Lymphoma. Cancer Management and Research, 14, 401-407. [Google Scholar] [CrossRef] [PubMed]
[34] Lv, K., Li, X., Yu, H., et al. (2020) Selection of New Immunotherapy Targets for NK/T Cell Lymphoma. American Journal of Translational Research, 12, 7034-7047.
[35] 缪正炀, 孙雪梅. 鼻型结外NK/T细胞淋巴瘤诊治进展[J]. 中外医学研究, 2022, 20(4): 180-184.
[36] Wenwen, H. 基于高通量测序探究三氧化二砷治疗急性早幼粒细胞白血病的分子机制[D]: [硕士学位论文]. 哈尔滨: 哈尔滨商业大学, 2024.
[37] 奚曼, 李慧波, 苏胜, 等. 三氧化二砷治疗复发及难治性血液病的疗效及作用机制[J]. 现代肿瘤医学, 2019, 27(15): 2795-2798.
[38] Zhong, L., Xu, F. and Chen, F. (2018) Arsenic Trioxide Induces the Apoptosis and Decreases NF-κB Expression in Lymphoma Cell Lines. Oncology Letters, 16, 6267-6274. [Google Scholar] [CrossRef] [PubMed]