NF-κB信号转导通路在自然流产中的研究现状
Current Status of Research on NF-κB Signal Transduction Pathway in Spontaneous Abortion
DOI: 10.12677/acm.2024.14123084, PDF,   
作者: 樊慕华, 匡洪影*：黑龙江中医药大学附属第一医院妇科，黑龙江 哈尔滨
关键词: NF-κB；自然流产；炎症因子；NF-κB； Spontaneous Abortion； Inflammatory Factors
摘要: 自然流产是临床常见的妊娠异常疾病，严重危害了育龄期女性的身心健康，其病因多种多样，发病机制尚未完全明晰。近几年的研究表明，NF-κB信号通路可以多途径妊娠进程，在胚胎植入与发育生长之间发挥重要的作用，自然流产的发生与NF-κB信号通路有关系。本文就近几年来NF-κB通路参与自然流产的机制研究进展进行综述，并对今后的研究方向进行探讨与展望。
Abstract: Spontaneous abortion is a common clinical abnormal pregnancy disease, which seriously endangers the physical and mental health of women of childbearing age. Its causes are diverse and the pathogenesis is not yet fully understood. Studies in recent years have shown that the NF-κB signaling pathway can play an important role in multiple pregnancy processes, between embryo implantation and development and growth, and the occurrence of spontaneous abortion is related to the NF-κB signaling pathway. This article reviews the research progress on the mechanism of NF-κB pathway involvement in spontaneous abortion in recent years, and discusses and prospects for future research directions.
文章引用：樊慕华, 匡洪影. NF-κB信号转导通路在自然流产中的研究现状[J]. 临床医学进展, 2024, 14(12): 324-329. https://doi.org/10.12677/acm.2024.14123084

参考文献

[1] 自然流产诊治中国专家共识编写组. 自然流产诊治中国专家共识(2020年版) [J]. 中国实用妇科与产科杂志, 2020, 36(11): 1082-1090.
[2] Mitchell, S., Vargas, J. and Hoffmann, A. (2016) Signaling via the NF-κB System. WIREs Systems Biology and Medicine, 8, 227-241. [Google Scholar] [CrossRef] [PubMed]
[3] Morgan, M.J. and Liu, Z. (2010) Crosstalk of Reactive Oxygen Species and NF-κB Signaling. Cell Research, 21, 103-115. [Google Scholar] [CrossRef] [PubMed]
[4] Mussbacher, M., Derler, M., Basílio, J. and Schmid, J.A. (2023) NF-κB in Monocytes and Macrophages—An Inflammatory Master Regulator in Multitalented Immune Cells. Frontiers in Immunology, 14, Article ID: 1134661. [Google Scholar] [CrossRef] [PubMed]
[5] Chen, X., Song, Q.L., Wang, J.Y., Ji, R., Cao, M.L., Guo, D.Y., et al. (2023) FKBP5 Regulates Trophoblast-Macrophage Crosstalk in Recurrent Spontaneous Abortion through PI3K/AKT and NF-κB Signaling Pathways. Free Radical Biology and Medicine, 209, 55-69. [Google Scholar] [CrossRef] [PubMed]
[6] Tian, F., Qin, C., Li, X., Wu, F., Liu, X., Xu, W., et al. (2015) Decreased Stathmin-1 Expression Inhibits Trophoblast Proliferation and Invasion and Is Associated with Recurrent Miscarriage. The American Journal of Pathology, 185, 2709-2721. [Google Scholar] [CrossRef] [PubMed]
[7] Liu, T., Ma, Y., Yin, Q., Zhou, H. and Fang, Y. (2021) Association of Β‐Arrestin1 and p53‐mdm2 Signaling in the Development of Missed Abortion. Journal of Obstetrics and Gynaecology Research, 47, 1675-1685. [Google Scholar] [CrossRef] [PubMed]
[8] 刘冰冰, 徐燕宁, 陈凌. 炎症细胞因子与胚胎停育的关系[J]. 国际妇产科学杂志, 2023, 50(4): 409-415.
[9] Wen, Y., Cheng, M., Qin, L. and Xu, W. (2022) TNFα‐Induced Abnormal Activation of TNFR/NF-κB/FTH1 in Endometrium Is Involved in the Pathogenesis of Early Spontaneous Abortion. Journal of Cellular and Molecular Medicine, 26, 2947-2958. [Google Scholar] [CrossRef] [PubMed]
[10] Zhang, X., Hu, Y., Zhang, Z., Zhang, X., Liang, L., Cui, X., et al. (2023) Inhibition of TMUB1 Blocks Apoptosis and NF-κB Pathway‐Mediated Inflammation in Recurrent Spontaneous Abortion. Immunity, Inflammation and Disease, 11, e879. [Google Scholar] [CrossRef] [PubMed]
[11] Zhu, D., Zou, H., Liu, J., Wang, J., Ma, C., Yin, J., et al. (2021) Inhibition of HMGB1 Ameliorates the Maternal-Fetal Interface Destruction in Unexplained Recurrent Spontaneous Abortion by Suppressing Pyroptosis Activation. Frontiers in Immunology, 12, Article ID: 782792. [Google Scholar] [CrossRef] [PubMed]
[12] Huang, Z., Du, G., Huang, X., Han, L., Han, X., Xu, B., et al. (2018) The Enhancer RNA lnc-SLC4A1-1 Epigenetically Regulates Unexplained Recurrent Pregnancy Loss (URPL) by Activating CXCL8 and NF-κB Pathway. eBioMedicine, 38, 162-170. [Google Scholar] [CrossRef] [PubMed]
[13] 许凡萍, 汪启兵, 刘艳玲, 等. 氧化应激与妊娠疾病的相关性研究[J]. 生命的化学, 2016, 36(6): 929-933.
[14] Rains, J.L. and Jain, S.K. (2015) Effect of Hyperketonemia (Acetoacetate) on Nuclear Factor-κB and P38 Mitogen-Activated Protein Kinase Activation Mediated Intercellular Adhesion Molecule 1 Upregulation in Endothelial Cells. Metabolic Syndrome and Related Disorders, 13, 71-77. [Google Scholar] [CrossRef] [PubMed]
[15] Sul, O. and Ra, S.W. (2021) Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-κB in Lung Epithelial Cells. Molecules, 26, Article No. 6949. [Google Scholar] [CrossRef] [PubMed]
[16] Heazell, A.E.P. and Crocker, I.P. (2008) Live and Let Die—Regulation of Villous Trophoblast Apoptosis in Normal and Abnormal Pregnancies. Placenta, 29, 772-783. [Google Scholar] [CrossRef] [PubMed]
[17] Straszewski-Chavez, S.L., Abrahams, V.M. and Mor, G. (2005) The Role of Apoptosis in the Regulation of Trophoblast Survival and Differentiation during Pregnancy. Endocrine Reviews, 26, 877-897. [Google Scholar] [CrossRef] [PubMed]

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