缺血性脑卒中出血转化发生机制的研究进展
Research Progress on the Mechanism of Hemorrhage Transformation in Ischemic Stroke
DOI: 10.12677/jcpm.2024.34231, PDF,    科研立项经费支持
作者: 蔡月丽*, 王玲玲#:北华大学附属医院神经内科,吉林 吉林;李鑫宇:吉林市化工医院神经内科,吉林 吉林
关键词: 出血性转化缺血性脑卒中病理生理学Hemorrhagic Transformation Ischemic Stroke Pathophysiology
摘要: 出血转化(Hemorrhagic transformation, HT)是缺血性脑卒中不良预后的严重并发症。本文将从炎症因子、基质金属蛋白酶、高迁移率族蛋白、细胞离子、氧化应激和血脑屏障,进行阐述缺血性脑卒中出血性转化的相关发病机制,并简述HT相关危险因素及逆转剂,有助于临床医师了解出血性转化并降低其风险。
Abstract: Hemorrhagic transformation (HT) is a serious complication of poor prognosis in ischemic stroke. In this paper, we will explain the pathogenesis of HT in ischemic stroke because of inflammatory factors, matrix metalloproteinases, high mobility group proteins, cell ions, oxidative stress and blood-brain barrier, and briefly describe the risk factors of HT and reversal agents, so as to help clinicians understand hemorrhagic transformation and reduce its risk.
文章引用:蔡月丽, 李鑫宇, 王玲玲. 缺血性脑卒中出血转化发生机制的研究进展[J]. 临床个性化医学, 2024, 3(4): 1611-1618. https://doi.org/10.12677/jcpm.2024.34231

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