WD蛋白亚家族对肿瘤作用机制的研究进展
The Research Progress of WD Protein Subfamily in Tumor Mechanism
DOI: 10.12677/md.2024.144063, PDF,   
作者: 何天颖*:华北理工大学研究生院,河北 唐山;刘 岩:华北理工大学生命科学学院,河北 唐山;张景华#:华北理工大学研究生院,河北 唐山;唐山市妇幼保健院乳腺外科,河北 唐山
关键词: 肿瘤WD蛋白亚家族分子调控Tumor WD Protein Subfamily Molecular Regulation
摘要: WD蛋白亚家族成员包含WSB1 (WD Repeat and SOCS Box Containing 1)和WSB2 (WD Repeat and SOCS Box Containing 2),它们的共同结构是WD40重复序列和C端一个细胞因子信号传导抑制因子(SOCS)盒。WD蛋白亚家族在肝细胞癌、前列腺癌、胰腺癌、神经母细胞瘤、乳腺癌等多种人体肿瘤中呈现异常表达,参与肿瘤细胞的增殖、转移、凋亡、治疗耐药等过程,并影响肿瘤的预后。本文主要就WD蛋白亚家族在肿瘤中的研究进展进行综述,以期为进一步研究其生物学功能、分子机制及临床研究提供理论参考。
Abstract: WD protein subfamily members include WSB1 (WD Repeat and SOCS Box Containing 1) and WSB2 (WD Repeat and SOCS Box Containing 2), which share a common structure consisting of a WD40 repeat sequence and a C-terminal SOCS (cellular factor signaling inhibitor) box. WD protein subfamily members exhibit abnormal expression in various human tumors, including hepatocellular carcinoma, prostate cancer, pancreatic cancer, neuroblastoma, and breast cancer, and participate in various processes of tumor cell proliferation, metastasis, apoptosis, and drug resistance. This review mainly summarizes the research progress of the WD protein subfamily in tumors.
文章引用:何天颖, 刘岩, 张景华. WD蛋白亚家族对肿瘤作用机制的研究进展[J]. 医学诊断, 2024, 14(4): 432-438. https://doi.org/10.12677/md.2024.144063

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