幽门螺杆菌致病机制与抗体分型检测的研究

Study on the Pathogenic Mechanism of Helicobacter pylori and the Detection of Antibody Typing

摘要: 幽门螺杆菌是世界公认的I类致癌因子，也是全球最常见、最广泛的感染性病原体之一，其感染会引起慢性胃炎，并会增加患消化性溃疡、胃腺癌和胃黏膜相关淋巴组织淋巴瘤等疾病的风险，此外它还与多种胃肠外疾病密切相关。尽管在过去的几十年里，中国及全球的幽门螺旋杆菌感染率一直在持续下降，但近年来随着抗生素耐药性的上升，幽门螺杆菌根除治疗受到严峻挑战。本文就幽门螺杆菌致病机制及抗体分型检测的临床价值做一综述，从而为有针对性地选择幽门螺杆菌检测方法提供一定的临床参考依据。

Abstract: Helicobacter pylori is a globally recognized Group I carcinogen and one of the most common and widespread infectious pathogens worldwide. Its infection can lead to chronic gastritis and elevate the risk of developing digestive ulcers, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Furthermore, it is closely linked to various extragastrointestinal diseases. Although the infection rate of Helicobacter pylori in China and globally has been continuously decreasing over the past few decades, the eradication treatment of Helicobacter pylori has been severely challenged in recent years due to the rise of antibiotic resistance. This article provides a review of the pathogenic mechanism of Helicobacter pylori and the clinical value of antibody typing detection, offering a clinical reference basis for targeted selection of Helicobacter pylori detection methods.