白蛋白尿与心血管疾病的研究进展
Research Progress of Albuminuria and Cardiovascular Disease
DOI: 10.12677/acm.2024.14123172, PDF,   
作者: 杜 洋, 佘 强*：重庆医科大学附属第二医院心血管内科，重庆
关键词: 白蛋白尿；心血管疾病；慢性肾脏病；预后；Albuminuria； Cardiovascular Disease； Chronic Kidney Disease； Prognosis
摘要: 白蛋白尿，作为一种生物标志物，其在慢性肾脏疾病(CKD)进展监测中的作用已得到广泛验证。然而，近年来的研究表明，白蛋白尿同样具有预测心血管疾病(CVD)风险的重要价值。例如，即使在GFR正常的患者中，白蛋白尿的存在与发生心力衰竭(HF)的可能性增加相关，并且最近有研究已经描述了白蛋白尿在动脉粥样硬化中的作用。白蛋白尿与死亡率和因心力衰竭住院等不良结局相关。然而，白蛋白尿的筛查率仍然较低。幸运的是，白蛋白尿的存在是可以改变的，现在有新的治疗方法可以逆转心肾相互作用中的这一常见风险因素。现就白蛋白尿的概念以及白蛋白尿与心血管疾病的关系及其潜在的病理生理机制作一综述，以期为心血管疾病的预防与治疗提供新的见解与策略。
Abstract: Albuminuria, as a biomarker, has been widely validated for its role in monitoring the progression of chronic kidney disease (CKD). However, recent studies have indicated that albuminuria also holds significant value in predicting cardiovascular disease (CVD) risk. For instance, even in patients with normal glomerular filtration rate (GFR), the presence of albuminuria is associated with an increased likelihood of developing heart failure (HF), and recent research has described the role of albuminuria in atherosclerosis. Albuminuria is correlated with adverse outcomes such as mortality and hospitalization due to heart failure. Nevertheless, the screening rate for albuminuria remains low. Fortunately, the presence of albuminuria is modifiable, and there are new treatment approaches available to reverse this common risk factor in the heart-kidney interaction. This review aims to provide an overview of the concept of albuminuria, its relationship with cardiovascular diseases, and its potential pathophysiological mechanisms, with the hope of offering new insights and strategies for the prevention and treatment of cardiovascular diseases.
文章引用：杜洋, 佘强. 白蛋白尿与心血管疾病的研究进展[J]. 临床医学进展, 2024, 14(12): 951-960. https://doi.org/10.12677/acm.2024.14123172

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