肠道菌群对结直肠癌ICB治疗的影响

Influence of Intestinal Flora on ICB Therapy for Colorectal Cancer

摘要: 肠道菌群对结直肠癌免疫检查点抑制剂(ICB)治疗的作用日益受到重视，调节肠道菌群成为了优化ICB治疗效果的一个重要研究方向，目前还缺乏既往有关肠道菌群对结直肠癌ICB治疗的研究成果的整合，并且也没有统一的临床治疗指南。本文系统、全面地探讨了肠道菌群对结直肠癌ICB治疗的影响，包括治疗机制、面临的挑战、肠道菌群与ICB治疗效果的关联、影响ICB治疗效果的肠道菌群特征等内容，并通过梳理相关文献进行了总结。本文研究表明肠道菌群在维持人体健康和疾病进程中扮演着关键角色，肠道菌群的不同组成能够显著影响ICB的治疗效果，通过粪便微生物移植、抗生素的合理使用、益生菌补充等方法调节肠道菌群成为了优化结直肠癌ICB治疗效果的一个重要研究方向。本文能够为临床制定肠道菌群干预结直肠癌ICB治疗提供一定的参考，并为更深入地探讨肠道菌群与ICB治疗之间的相互作用机制提供借鉴。

Abstract: The role of the gut microbiome in immunotherapy for colorectal cancer, particularly with immune checkpoint inhibitors (ICB), is increasingly being recognized. Modulating the gut microbiome has become an important area of research for optimizing the effects of ICB therapy. Currently, there is a lack of comprehensive integration of research findings on the gut microbiome’s impact on colorectal cancer ICB treatment, as well as a lack of unified clinical treatment guidelines. This article systematically and comprehensively explores the influence of the gut microbiome on colorectal cancer ICB treatment, including the mechanisms of therapy, challenges faced, the association between the gut microbiome and ICB treatment outcomes, and the characteristics of the gut microbiome that affect ICB treatment efficacy, summarized through a review of relevant literature. The study indicates that the gut microbiome plays a key role in maintaining human health and the disease process, with different compositions of the gut microbiome significantly impacting the efficacy of ICB treatment. Methods such as fecal microbiota transplantation, rational use of antibiotics, and probiotic supplementation to modulate the gut microbiome have become important research directions for optimizing colorectal cancer ICB treatment outcomes. This article provides references for the clinical development of gut microbiome interventions in colorectal cancer ICB treatment and offers insights for further exploration of the interaction mechanisms between the gut microbiome and ICB therapy.