残余胆固醇与心血管疾病风险研究进展
Research Progress on Residual Cholesterol and Cardiovascular Disease Risk
摘要: 近年来,针对低密度脂蛋白胆固醇水平(LDL-C)的药物治疗是动脉粥样硬化性心血管疾病预防和治疗的主要手段,但即使通过下调LDL-C水平仍然存在不良心血管事件发生风险。有研究表明残余胆固醇(remnant cholesterol, RC)可能是主要残余心血管风险的重要影响因素。本综述旨在将近年来对残余胆固醇的定义、计量方法、致动脉粥样硬化机制及证据、治疗方法等进展进行阐述。
Abstract: In recent years, drug therapy targeting low density lipoprotein cholesterol (LDL-C) level is the main means for the prevention and treatment of atherosclerotic cardiovascular disease. However, there is still a risk of adverse cardiovascular events even by reducing LDL-C level. Studies have shown that remnant cholesterol (RC) may be an important factor affecting the major residual cardiovascular risk. This review aims to elaborate on the definition, measurement methods, atherogenic mechanism and evidence, and treatment methods of residual cholesterol in recent years.
文章引用:唐安岑, 周成, 高燕. 残余胆固醇与心血管疾病风险研究进展[J]. 临床医学进展, 2024, 14(12): 1228-1233. https://doi.org/10.12677/acm.2024.14123209

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