离子组学在中枢神经系统性疾病中的研究进展
Research Progress of Ionomics in Central Nervous System Diseases
DOI: 10.12677/jcpm.2024.34306, PDF,    科研立项经费支持
作者: 徐向楠, 许 彪, 沈嵩民, 安 刚：济宁医学院临床医学院，山东 济宁；崔昌萌*, 王长水：济宁医学院附属医院神经外科，山东 济宁
关键词: 离子组学；创伤性脑损伤；中风；阿尔茨海默病；帕金森病；肌萎缩侧索硬化；Ionomics； TBI； Stroke； AD； PD； ALS
摘要: 离子在人类健康和疾病中起着重要作用。近年来，离子组学被应用于各种生理和病理过程中的分布、调控、功能和串扰。它结合高通量元素分析技术和生物信息学方法，阐明多种元素与疾病的代谢和稳态之间的关系。本综述旨在概述离子组学在中枢神经系统性疾病研究的新进展，主要关注不同生物样本离子组的分析研究，揭示了不同离子及复杂的动态离子网络对疾病发生与发展的影响，这为中枢神经系统性疾病早期诊断、治疗措施和预后等方面提供了潜在益处。
Abstract: Ions play an important role in human health and disease. In recent years, ionomics has been applied to the distribution, regulation, function and crosstalk in various physiological and pathological processes. It combines high-throughput elemental analysis techniques and bioinformatics approaches to elucidate the relationship between multiple elements and metabolism and homeostasis in diseases. The aim of this review is to provide an overview of new advances in ionomics in the study of CNS disorders, with a primary focus on analytical studies of the ionome of different biological samples, revealing the impact of different ions and complex dynamic ion networks on disease onset and progression, which offers potential benefits in terms of early diagnosis, therapeutic measures and prognosis of CNS disorders.
文章引用：徐向楠, 崔昌萌, 王长水, 许彪, 沈嵩民, 安刚. 离子组学在中枢神经系统性疾病中的研究进展[J]. 临床个性化医学, 2024, 3(4): 2161-2167. https://doi.org/10.12677/jcpm.2024.34306

参考文献

[1] Mertz, W. (1981) The Essential Trace Elements. Science, 213, 1332-1338. [Google Scholar] [CrossRef] [PubMed]
[2] Jomova, K., Makova, M., Alomar, S.Y., Alwasel, S.H., Nepovimova, E., Kuca, K., et al. (2022) Essential Metals in Health and Disease. Chemico-Biological Interactions, 367, Article ID: 110173. [Google Scholar] [CrossRef] [PubMed]
[3] Mounicou, S., Szpunar, J. and Lobinski, R. (2009) Metallomics: The Concept and Methodology. Chemical Society Reviews, 38, 1119-1138. [Google Scholar] [CrossRef] [PubMed]
[4] Baxter, I. (2009) Ionomics: Studying the Social Network of Mineral Nutrients. Current Opinion in Plant Biology, 12, 381-386. [Google Scholar] [CrossRef] [PubMed]
[5] Kuzan, A., Wujczyk, M. and Wiglusz, R.J. (2021) The Study of the Aorta Metallomics in the Context of Atherosclerosis. Biomolecules, 11, Article 946. [Google Scholar] [CrossRef] [PubMed]
[6] Temurer Afşar, Z., Ayçiçek, B., Tütüncü, Y., Çavdar, Ü. and Sennaroğlu, E. (2023) Relationships between Microvascular Complications of Diabetes Mellitus and Levels of Macro and Trace Elements. Minerva Endocrinology, 48, 305-310. [Google Scholar] [CrossRef] 
[7] Lizzo, J.M. and Waseem, M. (2024) Brain Trauma (Archived). StatPearls.
[8] Roberts, B.R., Hare, D.J., McLean, C.A., Conquest, A., Lind, M., Li, Q., et al. (2015) Traumatic Brain Injury Induces Elevation of Co in the Human Brain. Metallomics, 7, 66-70. [Google Scholar] [CrossRef] [PubMed]
[9] Belatar, B., Elabidi, A., Barkiyou, M., El Faroudi, M., Eljaoudi, R., Lahlou, L., et al. (2018) The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission. Journal of Toxicology, 2018, Article ID: 7252606. [Google Scholar] [CrossRef] [PubMed]
[10] Portbury, S.D., Hare, D.J., Sgambelloni, C., Finkelstein, D.I. and Adlard, P.A. (2016) A Time-Course Analysis of Changes in Cerebral Metal Levels Following a Controlled Cortical Impact. Metallomics, 8, 193-200. [Google Scholar] [CrossRef] [PubMed]
[11] Portbury, S.D., Hare, D.J., Sgambelloni, C.J., Bishop, D.P., Finkelstein, D.I., Doble, P.A., et al. (2017) Age Modulates the Injury-Induced Metallomic Profile in the Brain. Metallomics, 9, 402-410. [Google Scholar] [CrossRef] [PubMed]
[12] Juan, S.M.A., Daglas, M., Gunn, A.P., Lago, L. and Adlard, P.A. (2022) Characterization of the Spatial Distribution of Metals and Profile of Metalloprotein Complexes in a Mouse Model of Repetitive Mild Traumatic Brain Injury. Metallomics, 14, mfac092. [Google Scholar] [CrossRef] [PubMed]
[13] Juan, S.M.A., Daglas, M., Truong, P.H., Mawal, C. and Adlard, P.A. (2023) Alterations in Iron Content, Iron-Regulatory Proteins and Behaviour without Tau Pathology at One Year Following Repetitive Mild Traumatic Brain Injury. Acta Neuropathologica Communications, 11, Article No. 118. [Google Scholar] [CrossRef] [PubMed]
[14] Lin, C., Hsu, Y., Yen, C., Chen, H., Tseng, C., Lo, Y., et al. (2018) Association between Heavy Metal Levels and Acute Ischemic Stroke. Journal of Biomedical Science, 25, Article No. 49. [Google Scholar] [CrossRef] [PubMed]
[15] Mirończuk, A., Kapica-Topczewska, K., Socha, K., Soroczyńska, J., Jamiołkowski, J., Kułakowska, A., et al. (2021) Selenium, Copper, Zinc Concentrations and Cu/Zn, Cu/Se Molar Ratios in the Serum of Patients with Acute Ischemic Stroke in Northeastern Poland—A New Insight into Stroke Pathophysiology. Nutrients, 13, Article 2139. [Google Scholar] [CrossRef] [PubMed]
[16] Mirończuk, A., Kapica-Topczewska, K., Socha, K., Soroczyńska, J., Jamiołkowski, J., Chorąży, M., et al. (2023) Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke. Nutrients, 15, Article 1434. [Google Scholar] [CrossRef] [PubMed]
[17] Yen, C., Chen, H., Hsu, Y., Tseng, C. and Lin, C. (2022) Effects of Heavy Metals in Acute Ischemic Stroke Patients: A Cross-Sectional Study. Medicine, 101, e28973. [Google Scholar] [CrossRef] [PubMed]
[18] Wen, Y., Huang, S., Zhang, Y., Zhang, H., Zhou, L., Li, D., et al. (2019) Associations of Multiple Plasma Metals with the Risk of Ischemic Stroke: A Case-Control Study. Environment International, 125, 125-134. [Google Scholar] [CrossRef] [PubMed]
[19] Karadas, S., Sayın, R., Aslan, M., Gonullu, H., Katı, C., Dursun, R., et al. (2013) Serum Levels of Trace Elements and Heavy Metals in Patients with Acute Hemorrhagic Stroke. The Journal of Membrane Biology, 247, 175-180. [Google Scholar] [CrossRef] [PubMed]
[20] Xiao, Y., Yuan, Y., Liu, Y., Yu, Y., Jia, N., Zhou, L., et al. (2019) Circulating Multiple Metals and Incident Stroke in Chinese Adults. Stroke, 50, 1661-1668. [Google Scholar] [CrossRef] [PubMed]
[21] Nahan, K.S., Walsh, K.B., Adeoye, O. and Landero-Figueroa, J.A. (2017) The Metal and Metalloprotein Profile of Human Plasma as Biomarkers for Stroke Diagnosis. Journal of Trace Elements in Medicine and Biology, 42, 81-91. [Google Scholar] [CrossRef] [PubMed]
[22] Kodali, P., Chitta, K.R., Landero Figueroa, J.A., Caruso, J.A. and Adeoye, O. (2012) Detection of Metals and Metalloproteins in the Plasma of Stroke Patients by Mass Spectrometry Methods. Metallomics, 4, 1077-1087. [Google Scholar] [CrossRef] [PubMed]
[23] Soria Lopez, J.A., González, H.M. and Léger, G.C. (2019) Alzheimer’s disease. Handbook of Clinical Neurology, 167, 231-255. [Google Scholar] [CrossRef] [PubMed]
[24] Babić Leko, M., Mihelčić, M., Jurasović, J., Nikolac Perković, M., Španić, E., Sekovanić, A., et al. (2022) Heavy Metals and Essential Metals Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease. International Journal of Molecular Sciences, 24, Article 467. [Google Scholar] [CrossRef] [PubMed]
[25] Koseoglu, E., Koseoglu, R., Kendirci, M., Saraymen, R. and Saraymen, B. (2017) Trace Metal Concentrations in Hair and Nails from Alzheimer’s Disease Patients: Relations with Clinical Severity. Journal of Trace Elements in Medicine and Biology, 39, 124-128. [Google Scholar] [CrossRef] [PubMed]
[26] Lin, Y., Liang, C., Tsai, C., Tsai, C., Lee, J., Sung, Y., et al. (2022) A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: An Exploratory Study. Journal of Clinical Medicine, 11, Article 3655. [Google Scholar] [CrossRef] [PubMed]
[27] Wang, H., Wang, M., Wang, B., Li, M., Chen, H., Yu, X., et al. (2012) The Distribution Profile and Oxidation States of Biometals in APP Transgenic Mouse Brain: Dyshomeostasis with Age and as a Function of the Development of Alzheimer’s Disease. Metallomics, 4, 289-296. [Google Scholar] [CrossRef] [PubMed]
[28] Rao, S.S., Lago, L., Gonzalez de Vega, R., Bray, L., Hare, D.J., Clases, D., et al. (2019) Characterising the Spatial and Temporal Brain Metal Profile in a Mouse Model of Tauopathy. Metallomics, 12, 301-313. [Google Scholar] [CrossRef] [PubMed]
[29] Tabanez, M., Santos, I., Ikebara, J., Camargo, M., Dos Santos, B., Freire, B., et al. (2023) The Impact of Hydroxytyrosol on the Metallomic-Profile in an Animal Model of Alzheimer’s Disease. International Journal of Molecular Sciences, 24, Article 14950. [Google Scholar] [CrossRef] [PubMed]
[30] Murakami, H., Shiraishi, T., Umehara, T., Omoto, S. and Iguchi, Y. (2023) Recent Advances in Drug Therapy for Parkinson’s Disease. Internal Medicine, 62, 33-42. [Google Scholar] [CrossRef] [PubMed]
[31] Forte, G., Bocca, B., Senofonte, O., Petrucci, F., Brusa, L., Stanzione, P., et al. (2004) Trace and Major Elements in Whole Blood, Serum, Cerebrospinal Fluid and Urine of Patients with Parkinson’s Disease. Journal of Neural Transmission, 111, 1031-1040. [Google Scholar] [CrossRef] [PubMed]
[32] Alimonti, A., Bocca, B., Pino, A., Ruggieri, F., Forte, G. and Sancesario, G. (2007) Elemental Profile of Cerebrospinal Fluid in Patients with Parkinson’s Disease. Journal of Trace Elements in Medicine and Biology, 21, 234-241. [Google Scholar] [CrossRef] [PubMed]
[33] Sanyal, J., Ahmed, S.S.S.J., Ng, H.K.T., Naiya, T., Ghosh, E., Banerjee, T.K., et al. (2016) Metallomic Biomarkers in Cerebrospinal Fluid and Serum in Patients with Parkinson’s Disease in Indian Population. Scientific Reports, 6, Article No. 35097. [Google Scholar] [CrossRef] [PubMed]
[34] Kim, M., Oh, S., Kim, J., Kim, K., Ryu, H., Kim, M.S., et al. (2018) Association of Metals with the Risk and Clinical Characteristics of Parkinson’s Disease. Parkinsonism & Related Disorders, 55, 117-121. [Google Scholar] [CrossRef] [PubMed]
[35] Rajput, K., Afridi, H.I., Kazi, T.G., Talpur, F.N. and Baig, J.A. (2020) Sodium, Potassium, Calcium, and Magnesium in the Scalp Hair and Blood Samples Related to the Clinical Stages of the Parkinson’s Disease. Biological Trace Element Research, 199, 2582-2589. [Google Scholar] [CrossRef] [PubMed]
[36] Zhao, Y., Ray, A., Broberg, K., Kippler, M., Lill, C.M., Vineis, P., et al. (2023) Prediagnostic Blood Metal Levels and the Risk of Parkinson’s Disease: A Large European Prospective Cohort. Movement Disorders, 38, 2302-2307. [Google Scholar] [CrossRef] [PubMed]
[37] Lucio, M., Willkommen, D., Schroeter, M., Sigaroudi, A., Schmitt-Kopplin, P. and Michalke, B. (2019) Integrative Metabolomic and Metallomic Analysis in a Case-Control Cohort with Parkinson’s Disease. Frontiers in Aging Neuroscience, 11, Article 331. [Google Scholar] [CrossRef] [PubMed]
[38] Feldman, E.L., Goutman, S.A., Petri, S., Mazzini, L., Savelieff, M.G., Shaw, P.J., et al. (2022) Amyotrophic Lateral Sclerosis. The Lancet, 400, 1363-1380. [Google Scholar] [CrossRef] [PubMed]
[39] Roos, P.M., Vesterberg, O., Syversen, T., Flaten, T.P. and Nordberg, M. (2012) Metal Concentrations in Cerebrospinal Fluid and Blood Plasma from Patients with Amyotrophic Lateral Sclerosis. Biological Trace Element Research, 151, 159-170. [Google Scholar] [CrossRef] [PubMed]
[40] Peters, T.L., Beard, J.D., Umbach, D.M., Allen, K., Keller, J., Mariosa, D., et al. (2016) Blood Levels of Trace Metals and Amyotrophic Lateral Sclerosis. NeuroToxicology, 54, 119-126. [Google Scholar] [CrossRef] [PubMed]
[41] De Benedetti, S., Lucchini, G., Del Bò, C., Deon, V., Marocchi, A., Penco, S., et al. (2017) Blood Trace Metals in a Sporadic Amyotrophic Lateral Sclerosis Geographical Cluster. BioMetals, 30, 355-365. [Google Scholar] [CrossRef] [PubMed]
[42] Oggiano, R., Solinas, G., Forte, G., Bocca, B., Farace, C., Pisano, A., et al. (2018) Trace Elements in ALS Patients and Their Relationships with Clinical Severity. Chemosphere, 197, 457-466. [Google Scholar] [CrossRef] [PubMed]
[43] Patti, F., Fiore, M., Chisari, C.G., D’Amico, E., Lo Fermo, S., Toscano, S., et al. (2020) CSF Neurotoxic Metals/Metalloids Levels in Amyotrophic Lateral Sclerosis Patients: Comparison between Bulbar and Spinal Onset. Environmental Research, 188, Article ID: 109820. [Google Scholar] [CrossRef] [PubMed]
[44] Qin, X., Wu, P., Wen, T., Jia, R., Zhang, R., Jin, J., et al. (2022) Comparative Assessment of Blood Metal/Metalloid Levels, Clinical Heterogeneity, and Disease Severity in Amyotrophic Lateral Sclerosis Patients. NeuroToxicology, 89, 12-19. [Google Scholar] [CrossRef] [PubMed]