妊娠期急性脂肪肝的诊断及预后相关指标的探究

Exploration of Diagnostic and Prognostic Indicators for Acute Fatty Liver of Pregnancy

摘要: 妊娠期急性脂肪肝(AFLP)是一种妊娠期乃至产褥期罕见但危及生命的并发症，多发生在妊娠晚期，在80多年前首次被报道为一种独特的妊娠综合征。它对于母亲和胎儿而言通常都是致命的。AFLP早期仅表现为恶心、呕吐、腹部不适等，辅助检查时常不能提供有价值的线索，因此很难识别，而其又要依靠实验室检查结果和临床症状来做出诊断，这就导致了目前大多医生对其认识不足，使得AFLP的准确诊断和有效治疗成为医生临床工作中的挑战。充分了解AFLP的危险因素、临床特征和检查结果对于及时诊断和治疗至关重要。本文将对妊娠期急性脂肪肝的发病机制、诊断方式及预后相关指标进行综述，以期为临床提供参考。

Abstract: Acute fatty liver disease in pregnancy (AFLP) is a rare but life-threatening complication of pregnancy and puerperium that occurs more often during the third trimester and was first reported as a distinct pregnancy syndrome more than 80 years ago. It is usually fatal to both mother and fetus. Early manifestations of AFLP are only nausea, vomiting, abdominal discomfort, etc. Auxiliary examination often fails to provide valuable clues, so it is difficult to identify AFLP, and its diagnosis depends on laboratory examination results and clinical symptoms, which leads to the lack of understanding of AFLP by most doctors, making accurate diagnosis and effective treatment of AFLP a challenge for doctors in clinical work. A full understanding of the risk factors, clinical features and test results of AFLP is essential for its timely diagnosis and treatment. This article will review the pathogenesis, diagnostic methods and prognostic indicators of acute fatty liver in pregnancy, in order to provide clinical reference.