石菖蒲联合奥拉西坦治疗阿尔茨海默病研究进展

Research Progress on the Combination of Acorus tatarinowii Schott and Olacetam in the Treatment of Alzheimer’s Disease

摘要: 阿尔茨海默病(Alzheimer’s disease, AD)是一种对人类健康造成严重影响人类健康的神经退行性疾病。随着人口老龄化的加速，AD的发病率持续上升，给社会和家庭带来了巨大的负担。因此，寻找有效的治疗方案已成为一项重要的公共卫生挑战。在众多潜在治疗来源中，天然生物活性药物因其多途径靶向作用和低毒性而备受关注。中药在治疗AD方面具有独特的优势，尤其是石菖蒲因其开窍豁痰、醒神益智的功效，在临床上被广泛应用于AD等病证的治疗。奥拉西坦作为一种临床药物，已在AD治疗中得到应用，但其单独使用可能存在局限性。大量研究表明石菖蒲中的主要成分确实能够穿越血脑屏障进入大脑，并且与临床药物奥拉西坦联合使用时，可能增强药物的吸收效果，从而提升治疗效果。本文将重点讨论中药石菖蒲联合奥拉西坦在治疗阿尔茨海默病方面的研究进展，以期为阿尔茨海默病的治疗提供新的依据。

Abstract: Alzheimer’s disease (AD) is a neurodegenerative disease that seriously affects human health. With the acceleration of the aging of the population, the incidence rate of AD continues to rise, bringing a huge burden to society and families. Therefore, finding effective treatment options has become an important public health challenge. Among numerous potential therapeutic sources, natural bioactive drugs have attracted much attention due to their multi pathway targeting effects and low toxicity. Traditional Chinese medicine has unique advantages in the treatment of AD, especially Acorus tatarinowii Schott, which is widely used in clinical practice for the treatment of AD and other diseases due to its effects of opening the orifices, eliminating phlegm, awakening the mind, and improving intelligence. Olacetam, as a clinical drug, has been used in the treatment of AD, but its use alone may have limitations. Numerous studies have shown that the main components in Acorus tatarinowii Schott can indeed cross the blood-brain barrier and enter the brain. When used in combination with the clinical drug Olacetam, it may enhance the absorption effect of the drug, thereby improving the therapeutic effect. This article will focus on the research progress of the combination of traditional Chinese medicine Acorus tatarinowii Schott and Olacetam in the treatment of Alzheimer’s disease, in order to provide new evidence for the treatment of Alzheimer’s disease.