TyG、TyG-BMI、脂质比与中老年人高尿酸血症的相关性研究
Study on the Correlation between TyG, TyG-BMI and Hyperuricemia and TG/HDL-C in middle-aged and elderly populations
DOI: 10.12677/jcpm.2024.34329, PDF,   
作者: 谭识洁, 胡传萌：济宁医学院临床医学院，山东 济宁；伊鹏飞, 孟灿灿, 孙海玲*：济宁医学院附属医院保健与国际医疗部，山东 济宁
关键词: TG/HDL-C；TyG指数；TyG-BMI；高尿酸血症；TG/HDL-C； TyG Index； TyG-BMI； Hyperuricemia
摘要: 目的：探讨中老年人群甘油三酯/高密度脂蛋白胆固醇(triglyceride/high density lipoprotein cholesterol ratio, TG/HDL-C)、甘油三酯–葡萄糖乘积(riglyceride-glucose index, TyG)指数及TyG-BMI (riglyceride-glucose index-body mass index, TyG-BMI)与高尿酸血症(hyperuricemia, HUA)的相关性，同时分析TG/HDL-C、TyG以及TyG-BMI预测HUA的能力。方法：获取2022至01月01日至2023年6月30日健康体检中心年龄在45岁以上1165例受检者进行回顾性分析，将研究对象分为HUA组(n = 139)和NUA组(n = 966)，分析两组间的人群的一般情况、生化指标、TG/HDL-C、TyG指数及TyG-BMI的差异。运用Logistic回归分析，ROC曲线分析TyG、TyG-BMI、脂质比与HUA的相关性。结果：Logistic回归分析显示，Logistic回归分析提示TG/HDL-C为HUA的危险因素，在调整混杂因素后，仍保持着这种关系。在TyG、TyG-BMI中也可发现类似的结果。ROC曲线分析显示，TyG指数、TG/HDL-C、TyG-BMI预测HUA的ROC曲线下面积分别为0.675、0.656、0.701、0.725 (p < 0.001)。结论：TG/HDL-C、TyG指数及TyG-BMI与HUA的关系密切，均为HUA的危险因素。与TG/HDL-C比值、TyG指数相比，TyG-BMI对HUA诊断价值更高。
Abstract: Objective: To investigate the correlation between triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C), triglyceride glucose index (TyG), and TyG-BMI (TyG-BMI) and hyperuricemia (HUA) in middle-aged and elderly populations, and to analyze the predictive ability of TG/HDL-C, TyG, and TyG-BMI for HUA. Method: A retrospective analysis was conducted on 1165 subjects aged 45 and above at the Health Examination Center from January 1, 2022 to June 30, 2023. The study subjects were divided into HUA group (n = 139) and NUA group (n = 966), and the differences in general information, biochemical indicators, TG/HDL-C, TyG index, and TyG-BMI between the two groups were analyzed, using logistic regression analysis and ROC curve analysis to examine the correlation between TyG, TyG-BMI, lipid ratio, and HUA. Result: Logistic regression analysis showed that TG/HDL-C was a risk factor for HUA, and this relationship remained after adjusting for confounding factors. Similar results can also be found in TyG and TyG-BMI. ROC curve analysis showed that the areas under the ROC curves for predicting HUA using TyG index, TG/HDL-C, and TyG-BMI were 0.675, 0.656, 0.701, and 0.725, respectively (p < 0.001). Conclusion: TG/HDL-C, TyG index, and TyG-BMI are closely related to HUA and are all risk factors for HUA. Compared with the TG/HDL-C ratio and TyG index, TyG-BMI has higher diagnostic value for HUA.
文章引用：谭识洁, 伊鹏飞, 胡传萌, 孟灿灿, 孙海玲. TyG、TyG-BMI、脂质比与中老年人高尿酸血症的相关性研究[J]. 临床个性化医学, 2024, 3(4): 2306-2314. https://doi.org/10.12677/jcpm.2024.34329

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