白介素-17介导炎症反应与干眼症

Interleukin-17 Mediates Inflammatory Reactions and Dry Eye Disease

摘要: 干眼症(Dry Eye Disease, DED)以双眼干涩不适、异物感、瘙痒、畏光为主要症状，干眼症的发病机制复杂，与泪膜稳定性破坏、免疫炎症反应、角膜周围神经损伤等有关。根据最新的研究，白细胞介素-17 (interleukin-17, IL-17)在干眼症患者泪液中呈高表达状态，它是白细胞介素家族的成员之一，主要由CD4⁺ T淋巴细胞的分泌，能够有效地聚合中性粒细胞，同时能够促进IL-17调节前炎性因子、趋化因子等多种细胞因子的释放，是干眼症发病机制中的重要环节。通过对DED的深入探索，我们能够更好地了解IL-17在干眼症的发病机制，并利用这些信息来早期诊断和干预DED。使我们更好地应对DED带来的挑战，并为患者提供更好的治疗方案。

Abstract: Characterized by dryness, discomfort in both eyes, a foreign body sensation, itching, and photophobia, Dry Eye Disease (DED) is a complex pathogenesis that is linked to the disruption of tear film stability, immune inflammatory responses, and damage to the nerves surrounding the cornea. Research has shown that interleukin-17 (IL-17) plays an important role in dry eye disease. As one of the members of the interleukin family, IL-17 is mainly secreted by CD4⁺ T lymphocytes. It has the unique function of strongly recruiting neutrophils and promoting the release of various cytokines such as pre-inflammatory factors and chemokines regulated by IL-17, playing a crucial role in the pathogenesis of dry eye. Through in-depth exploration of DED, we can better understand the role of IL-17 in the pathogenesis of dry eye disease. By leveraging this information, we can achieve early diagnosis and intervention for DED. This enables us to better address the challenges posed by DED and provide patients with improved treatment plans.