应用新型血栓四项检查预测下肢动脉硬化闭塞症抗凝治疗的意义

The Significance of Applying the New Thrombus Tetrogram in Predicting Anticoagulation Therapy for Peripheral Artery Disease

摘要: 目的：研究应用血栓四项检查在下肢动脉硬化闭塞症(Peripheral Artery Disease, PAD)患者抗凝治疗的意义。方法：选取2023年1月至2024年6月在本院接受治疗的PAD患者70例，收集年龄、性别、胆固醇、烟草使用、高血压、糖尿病、血栓四项，分析各个患者抗凝剂使用与血栓四项检查结果的相关性。结果：1) 年龄p = 0.975 > 0.05、吸烟者p = 0.187 > 0.05、手术类型p = 0.288 > 0.05、Fontaine分级p = 0.449 > 0.05不会显著影响阳性率表明与阳性率之间没有统计学上的显著关联。2) 女性抗凝治疗有效阳性率高于男性(p = 0.045 < 0.05)手术后患者抗凝治疗有效阳性率高于未手术患者(p = 0.017 < 0.05)，差异存在统计学意义。应用血栓四项检查在PAD患者抗凝剂使用中具备重要的临床价值，有助于指导抗凝治疗方案的制定。

Abstract: Objective: This paper aims to study the significance of applying thrombus tetrogram in the anticoagulation therapy of patients with Peripheral Artery Disease (PAD). Methods: Seventy patients with PAD who were treated in our hospital from January 2023 to June 2024 were selected, and age, gender, cholesterol, tobacco use, hypertension, diabetes, and thrombus IV were collected to analyze the correlation between the use of anticoagulants and the results of thrombus tetrogram in each patient. Results: 1) Age p = 0.975 > 0.05, smoker p = 0.187 > 0.05, type of surgery p = 0.288 > 0.05, and Fontaine’s classification p = 0.449 > 0.05 do not significantly affect the positive rate indicating no statistically significant association with the positive rate. 2) The effective positive rate of anticoagulant therapy in women is higher than that in men (p = 0.045 < 0.05). The effective positive rate of anticoagulant therapy in postoperative patients is higher than that in non-surgical patients (p = 0.017 < 0.05), indicating that the difference is statistically significant. The application of the thrombus tetrogram tests has significant clinical value in the use of anticoagulants in patients with PAD and helps to guide the development of anticoagulant regimens.