高剪切作用下大蒜素的制备研究

Preparation of Allicin under High-Shear Action

摘要: 二烯丙基硫醚，作为大蒜素的关键成分，展现出了显著的抗菌、抗病毒、降血压和降脂效果。它不仅能够预防心血管疾病和冠心病，还具有抗癌和减肥的功效。因此，二烯丙基硫醚在医药、农业、饲料添加剂以及食品等行业中得到了广泛的应用。本文以氯丙烯、硫代硫酸钠、硫化钠为原料，通过一锅两步反应，首次利用高剪切技术强化水相中二烯丙基硫醚的制备过程，考察了原料的配比、反应时间、反应温度以及相转移催化剂的用量及类型对该反应的影响，获得二烯丙基三硫醚和二烯丙基二硫醚的最佳工艺流程。该方法具有反应速度快、转化率高、选择性好、后处理简单等优点。

Abstract: Diallyl sulphide, as the major component of allicin, has antibacterial, antiviral, blood pressure-lowering and lipid-lowering effects, and is capable of preventing and treating cardiovascular diseases and coronary heart disease as well as anti-cancer and weight-loss effects. Therefore, it has a wide range of applications in the pharmaceutical, agricultural, feed additive and food industries. In this paper, the preparation process of diallyl sulfide in the aqueous phase was enhanced for the first time by using high shear technology through a one-pot, two-step reaction with chloropropene, sodium thiosulfate, and sodium sulfide as raw materials, and the influences of the ratio of the raw materials, the reaction time, the reaction temperature, as well as the dosage and type of the phase-transfer catalysts on the reaction were investigated, to obtain the optimal process for the preparation of diallyl trisulfide and diallyl disulfide. The method has the advantages of fast reaction speed, high conversion, good selectivity and simple post-treatment.