抗结核药物致药物性皮疹并发肝损伤患者抗痨方案重整一例

A Case of Anti-Tuberculosis Regimen Reconstruction for a Patient with Drug-Induced Rash and Liver Injury Caused by Anti-Tuberculosis Drugs

摘要: 文章详细报道了一例在使用抗结核药物后出现药疹并发肝损伤的病例。患者在抗结核治疗期间，出现类似皮肤过敏反应的症状，经详细检查和评估，考虑为抗结核药物导致的药物性皮疹同时并发肝损伤。经对症处理及保肝治疗后，患者药疹症状缓解，待肝功能恢复正常，通过药物激发试验，给患者逐一试用抗结核药物并重新引入抗痨方案。本病例提示临床医生在使用抗结核药物时，需密切关注患者的皮肤状况及肝肾功能指标，以早期发现并处理药物不良反应。且通过对该病例的诊断和治疗过程进行详细地分析和总结，旨在增强临床工作者对抗结核药使用过程中可能出现的副作用的认识，并为临床实践提供参考和借鉴。

Abstract: A case of drug-induced rash and concomitant liver injury following anti-TB therapy was reported in detail. During treatment, the patient developed symptoms resembling a skin allergic reaction. Comprehensive examination and evaluation confirmed that the rash and liver injury were caused by anti-TB drugs. Symptomatic management and hepatoprotective treatment were provided, resulting in symptom resolution. Once liver function normalized, anti-TB drugs were reintroduced sequentially through drug challenge tests, and the anti-TB regimen was successfully restructured. This case underscored the need for clinicians to closely monitor skin and hepatic function during anti-TB therapy to detect and manage adverse drug reactions early. The detailed analysis of this case aimed to enhance clinical awareness of potential adverse effects associated with anti-TB drugs and provide practical guidance for clinical decision-making.