卒中后认知障碍的预测与识别
Prediction and Recognition of Post-Stroke Cognitive Impairment
DOI: 10.12677/acm.2025.151046, PDF,   
作者: 韩诗雨, 杨东东*：成都中医药大学附属医院神经内科，四川 成都
关键词: 卒中后认知障碍；预测与识别；认知量表；影像学；生物标志物；PSCI； Prediction and Recognition； Cognitions Scale； Iconography； Biomarker
摘要: 卒中后认知障碍往往给患者本人及其家庭带来严重的精神及经济负担。能够尽量早期地预测卒中后认知障碍可以对患者进行早期管理，以减少认知下降导致的不良事件，并减轻家庭负担。本文通过对既往相关临床试验进行检索和总结，文章主要从量表与模型、影像学、生物标志物三个方面论述卒中后认知障碍的预测与识别方法。
Abstract: Cognitive impairment after stroke often brings serious mental and economic burden to patients and their families. Being able to predict cognitive impairment after stroke as early as possible can lead to early management of patients to reduce adverse events resulting from cognitive decline and reduce the burden on families. Based on the retrieval and summary of previous relevant clinical trials, this paper mainly discusses the prediction and recognition methods of post-stroke cognitive impairment from three aspects: scale and model, imaging, and biomarkers.
文章引用：韩诗雨, 杨东东. 卒中后认知障碍的预测与识别[J]. 临床医学进展, 2025, 15(1): 333-338. https://doi.org/10.12677/acm.2025.151046

参考文献

[1] 汪凯, 董强, 郁金泰, 胡盼盼. 卒中后认知障碍管理专家共识2021 [J]. 中国卒中杂志, 2021, 16(4): 376-389.
[2] Kuźma, E., Lourida, I., Moore, S.F., Levine, D.A., Ukoumunne, O.C. and Llewellyn, D.J. (2018) Stroke and Dementia Risk: A Systematic Review and Meta‐analysis. Alzheimer’s & Dementia, 14, 1416-1426. [Google Scholar] [CrossRef] [PubMed]
[3] Mijajlović, M.D., Pavlović, A., Brainin, M., Heiss, W., Quinn, T.J., Ihle-Hansen, H.B., et al. (2017) Post-Stroke Dementia—A Comprehensive Review. BMC Medicine, 15, Article No. 11. [Google Scholar] [CrossRef] [PubMed]
[4] Shi, D., Chen, X. and Li, Z. (2018) Diagnostic Test Accuracy of the Montreal Cognitive Assessment in the Detection of Post-Stroke Cognitive Impairment under Different Stages and Cutoffs: A Systematic Review and Meta-analysis. Neurological Sciences, 39, 705-716. [Google Scholar] [CrossRef] [PubMed]
[5] Droś, J. and Klimkowicz‐Mrowiec, A. (2021) Current View on Post-Stroke Dementia. Psychogeriatrics, 21, 407-417. [Google Scholar] [CrossRef] [PubMed]
[6] Kandiah, N., Chander, R.J., Lin, X., Ng, A., Poh, Y.Y., Cheong, C.Y., et al. (2016) Cognitive Impairment after Mild Stroke: Development and Validation of the SIGNAL2 Risk Score. Journal of Alzheimer’s Disease, 49, 1169-1177. [Google Scholar] [CrossRef] [PubMed]
[7] Ding, M., Xu, Y., Wang, Y., Li, P., Mao, Y., Yu, J., et al. (2019) Predictors of Cognitive Impairment after Stroke: A Prospective Stroke Cohort Study. Journal of Alzheimer’s Disease, 71, 1139-1151. [Google Scholar] [CrossRef] [PubMed]
[8] Molad, J., Hallevi, H., Korczyn, A.D., Kliper, E., Auriel, E., Bornstein, N.M., et al. (2019) Vascular and Neurodegenerative Markers for the Prediction of Post-Stroke Cognitive Impairment: Results from the TABASCO Study. Journal of Alzheimer’s Disease, 70, 889-898. [Google Scholar] [CrossRef] [PubMed]
[9] Pasi, M., Sugita, L., Xiong, L., Charidimou, A., Boulouis, G., Pongpitakmetha, T., et al. (2021) Association of Cerebral Small Vessel Disease and Cognitive Decline after Intracerebral Hemorrhage. Neurology, 96, e182-e192. [Google Scholar] [CrossRef] [PubMed]
[10] 孙国臣, 张文召. DTI脑网络分析对早期卒中后认知障碍的预测价值[J]. 国际精神病学杂志, 2020, 47(5): 972-975.
[11] Chi, N., Chao, S., Huang, L., Chan, L., Chen, Y., Chiou, H., et al. (2019) Plasma Amyloid Beta and Tau Levels Are Predictors of Post-Stroke Cognitive Impairment: A Longitudinal Study. Frontiers in Neurology, 10, Article 715. [Google Scholar] [CrossRef] [PubMed]
[12] Huang, L., Chao, S., Hu, C., Chien, L., Chiou, H., Lo, Y., et al. (2022) Plasma Phosphorylated-Tau181 Is a Predictor of Post-Stroke Cognitive Impairment: A Longitudinal Study. Frontiers in Aging Neuroscience, 14, Article 889101. [Google Scholar] [CrossRef] [PubMed]
[13] Jia, H., Li, H., Liu, Y., Liu, C. and Xue, M. (2020) Elevated Serum Alkaline Phosphatase as a Predictor of Cognitive Impairment in Patients with Acute Ischaemic Stroke: A Retrospective Cohort Study. Archives of Gerontology and Geriatrics, 89, Article ID: 104104. [Google Scholar] [CrossRef] [PubMed]
[14] Gao, Y., Wang, B., Miao, Y. and Han, Y. (2022) Serum Neuroglobin as a Potential Prognostic Biomarker for Cognitive Impairment after Intracerebral Hemorrhage. Frontiers in Neurology, 13, Article 885323. [Google Scholar] [CrossRef] [PubMed]
[15] 侯越, 赵妍, 王友明, 张如路, 王敏佳. 脑卒中患者血清胱抑素C水平与卒中后认知障碍相关性的Meta分析[J]. 现代检验医学杂志, 2022, 37(2): 142-147.
[16] Ye, S., Pan, H., Li, W., Wang, B., Xing, J. and Xu, L. (2022) High Serum Amyloid a Predicts Risk of Cognitive Impairment after Lacunar Infarction: Development and Validation of a Nomogram. Frontiers in Neurology, 13, Article 972771. [Google Scholar] [CrossRef] [PubMed]
[17] Wang, Y., Lu, W., Ning, W., Chen, Y. and Li, L. (2021) Decreased Levels of Serum IL‐34 Associated with Cognitive Impairment in Vascular Dementia. BioMed Research International, 2021, Article ID: 6793860. [Google Scholar] [CrossRef] [PubMed]
[18] Zhao, P., Zhang, G., Wang, Y., Wei, C., Wang, Z., Zhai, W., et al. (2024) Peripheral Immunity Is Associated with Cognitive Impairment after Acute Minor Ischemic Stroke and Transient Ischemic Attack. Scientific Reports, 14, Article No. 16201. [Google Scholar] [CrossRef] [PubMed]
[19] Zha, F., Zhao, J., Chen, C., Ji, X., Li, M., Wu, Y., et al. (2022) A High Neutrophil-To-Lymphocyte Ratio Predicts Higher Risk of Poststroke Cognitive Impairment: Development and Validation of a Clinical Prediction Model. Frontiers in Neurology, 12, Article 755011. [Google Scholar] [CrossRef] [PubMed]
[20] Pu, M., You, Y. and Wang, X. (2022) Predictive Value of Serum Matrix Metalloproteinase 9 Combined with Tissue Inhibitor of Metalloproteinase 1 for Post-Stroke Cognitive Impairment. Journal of Clinical Neuroscience, 105, 103-108. [Google Scholar] [CrossRef] [PubMed]
[21] Tu, X., Qiu, H., Lin, S., He, W., Huang, G., Zhang, X., et al. (2018) Low Levels of Serum Magnesium Are Associated with Poststroke Cognitive Impairment in Ischemic Stroke Patients. Neuropsychiatric Disease and Treatment, 14, 2947-2954. [Google Scholar] [CrossRef] [PubMed]
[22] Liu, Y., Kong, C., Gong, L., Zhang, X., Zhu, Y., Wang, H., et al. (2020) The Association of Post-Stroke Cognitive Impairment and Gut Microbiota and Its Corresponding Metabolites. Journal of Alzheimer’s Disease, 73, 1455-1466. [Google Scholar] [CrossRef] [PubMed]
[23] Wu, J., Xue, J., Zhuang, L. and Liu, C. (2020) Plasma Parameters and Risk Factors of Patients with Post-Stroke Cognitive Impairment. Annals of Palliative Medicine, 9, 45-52. [Google Scholar] [CrossRef] [PubMed]
[24] Ayehu, G.W., Admasu, F.T., Yitbarek, G.Y., Agegnehu Teshome, A., Amare, A.T., Atlaw, D., et al. (2023) Early Post-Stroke Cognitive Impairment and In-Hospital Predicting Factors among Stroke Survivors in Ethiopia. Frontiers in Neurology, 14, Article 1163812. [Google Scholar] [CrossRef] [PubMed]

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