维生素D3辅助治疗变应性鼻炎的疗效及对外周血嗜酸性粒细胞的影响

Effect of Vitamin D3 in Adjuvant Treatment of Allergic Rhinitis and Its Influence on Peripheral Blood Eosinophils

摘要: 目的：探讨维生素D3辅助治疗变应性鼻炎(AR)的疗效及对外周血嗜酸性粒细胞(EOS)的影响。方法：选取该院2023年7月~2024年6月的82例AR患者，随机分为A组与B组。A组41例给予枸地氯雷他定治疗，B组41例在A组基础上给予维生素D3治疗，比较2组患者的临床疗效、症状缓解时间、血清相关指标。结果：B组的临床疗效总有效率为95.12%，高于A组的80.49%，P < 0.05。B组的鼻痒、喷嚏、清涕、鼻塞缓解时间短于A组，P < 0.001。B组治疗后的EOS、ECP、IgE低于A组，P < 0.001。结论：维生素D3辅助治疗AR的疗效较好，能够加速症状缓解，减少EOS浸润及ECP释放，降低IgE水平，值得推广。

Abstract: Objective: To investigate the therapeutic effect of vitamin D3 adjuvant therapy on allergic rhinitis (AR) and its impact on peripheral blood eosinophils (EOS). Method: 82 AR patients from July 2023 to June 2024 in the hospital were randomly divided into Group A and Group B. 41 patients in Group A were treated with desloratadine citrate, while 41 patients in Group B were treated with vitamin D3 in addition to Group A. The clinical efficacy, symptom relief time, and serum related indicators of the two groups were compared. Result: The total effective rate of clinical efficacy in Group B was 95.12%, higher than Group A’s 80.49%, P < 0.05. The relief time of nasal itching, sneezing, runny nose, and nasal congestion in Group B was shorter than that in Group A, P < 0.001. The EOS, ECP, and IgE levels in Group B were lower than those in Group A after treatment, with P < 0.001. Conclusion: Vitamin D3 adjuvant therapy has a good therapeutic effect on AR, which can accelerate symptom relief, reduce EOS infiltration and ECP release, and lower IgE levels. It is worth promoting.