CH25H和25-HC与冠状动脉性心脏病
CH25H and 25-HC in Coronary Artery Disease
摘要: 冠状动脉性心脏病(coronary artery disease, CAD)显著影响着我国居民的健康，也给全球医疗带来巨大的经济负担。动脉粥样硬化(atherosclerosis, AS)是CAD的病理基础。胆固醇-25-羟化酶(cholesterol 25-hydroxylase, CH25H)是一种参与脂质代谢的酶，它可以将胆固醇催化生成25-羟基胆固醇(25-hydroxycholesterol, 25-HC)，而25-HC是众所周知的胆固醇的氧化产物，即氧甾醇。既往的研究表明CH25H和25-HC在调节胆固醇的代谢、炎症反应、AS以及免疫反应和抗病毒感染等方面发挥多种作用。近年来越来越多的研究聚焦于CH25H和25-HC与AS和CAD的相关性。因此本文就CH25H和25-HC在AS和CAD中已知的作用机制简单作一综述。
Abstract: Coronary artery disease (CAD) significantly affects the health of Chinese residents and imposes a huge economic burden on global healthcare. Atherosclerosis (AS) is the pathological basis of CAD. Cholesterol 25 hydroxylase (CH25H) is an enzyme involved in lipid metabolism. It catalyzes the conversion of cholesterol into 25-hydroxycholesterol (25-HC), which is a well-known oxidation product of cholesterol. Previous studies have shown that CH25H and 25-HC play multiple roles in regulating cholesterol metabolism, inflammatory response, AS, immune response, and antiviral infection. In recent years, more and more research has focused on the correlation between CH25H and 25-HC with AS and CAD. Therefore, this article provides a brief overview of the known mechanisms of action of CH25H and 25-HC in AS and CAD.
文章引用：张姿霄, 张爱文. CH25H和25-HC与冠状动脉性心脏病[J]. 临床医学进展, 2025, 15(1): 1040-1045. https://doi.org/10.12677/acm.2025.151139

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