出院后家庭氧疗对支气管肺发育不良早产儿预后的影响
The Impact of the Prognosis of Home Oxygen Use among Preterm Infants with Bronchopulmonary Dysplasia after Discharge
DOI: 10.12677/acm.2025.151140, PDF,   
作者: 周 涛, 王建辉*:重庆医科大学附属儿童医院新生儿诊治中心,国家儿童健康与疾病临床医学研究中心,儿童发育疾病研究教育部重点实验室,儿科学重庆市重点实验室,重庆
关键词: 早产儿支气管肺发育不良家庭氧疗预后Preterm Infant Bronchopulmonary Dysplasia Home Oxygen Therapy Prognosis
摘要: 支气管肺发育不良是早产儿最常见的呼吸系统并发症,给家庭和社会带来沉重负担。支气管肺发育不良可增加早产儿发生不良神经发育结局风险,包括发育迟缓、心理学习障碍等。这考虑与其住院时间延长、间隙性低氧血症发作等不良因素相关。近年来,出院后家庭氧疗在支气管肺发育不良患儿中的使用越来越广泛。然而出院后行家庭氧疗是否能够改善支气管肺发育不良患儿的临床预后尚不明确,并且,国内外由于医疗体系的差异,家庭氧疗的具体实施有很大差别,表现在干预效果上也可能有所差别。因此本文将出院后家庭氧疗可能带来的益处和潜在危害进行了综述。
Abstract: Bronchopulmonary dysplasia is the most common respiratory complication in preterm infants, placing a heavy burden on families and society. Bronchopulmonary dysplasia can increase the risk of adverse neurodevelopmental outcomes in preterm infants, including developmental delay and psychological learning disabilities. This is considered to be associated with adverse factors such as prolonged hospital stay and intermittent hypoxaemic episodes. In recent years, the use of post-discharge home oxygen therapy in children with bronchopulmonary dysplasia has become more widespread. However, it is not clear whether post-discharge home oxygen therapy can improve the clinical prognosis of children with bronchopulmonary dysplasia, and the implementation of home oxygen therapy varies greatly between China and abroad due to the differences in healthcare systems, which may be reflected in differences in the effectiveness of the intervention. Therefore, this paper reviews the possible benefits and potential harms of home oxygen therapy after hospital discharge.
文章引用:周涛, 王建辉. 出院后家庭氧疗对支气管肺发育不良早产儿预后的影响[J]. 临床医学进展, 2025, 15(1): 1046-1052. https://doi.org/10.12677/acm.2025.151140

参考文献

[1] Abman, S.H., Collaco, J.M., Shepherd, E.G., Keszler, M., Cuevas-Guaman, M., Welty, S.E., et al. (2017) Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia. The Journal of Pediatrics, 181, 12-28.e1. [Google Scholar] [CrossRef] [PubMed]
[2] Miller, A.N., Curtiss, J. and Kielt, M.J. (2024) Nutritional Needs of the Infant with Bronchopulmonary Dysplasia. NeoReviews, 25, e12-e24. [Google Scholar] [CrossRef] [PubMed]
[3] Mourani, P.M., Kinsella, J.P., Clermont, G., Kong, L., Perkins, A.M., Weissfeld, L., et al. (2014) Intensive Care Unit Readmission during Childhood after Preterm Birth with Respiratory Failure. The Journal of Pediatrics, 164, 749-755.e3. [Google Scholar] [CrossRef] [PubMed]
[4] Askie, L.M., Henderson-Smart, D.J., Irwig, L. and Simpson, J.M. (2003) Oxygen-Saturation Targets and Outcomes in Extremely Preterm Infants. New England Journal of Medicine, 349, 959-967. [Google Scholar] [CrossRef] [PubMed]
[5] Nakashima, T., Inoue, H., Sakemi, Y., Ochiai, M., Yamashita, H. and Ohga, S. (2021) Trends in Bronchopulmonary Dysplasia among Extremely Preterm Infants in Japan, 2003-2016. The Journal of Pediatrics, 230, 119-125.e7. [Google Scholar] [CrossRef] [PubMed]
[6] Jensen, E.A. and Schmidt, B. (2014) Epidemiology of Bronchopulmonary Dysplasia. Birth Defects Research Part A: Clinical and Molecular Teratology, 100, 145-157. [Google Scholar] [CrossRef] [PubMed]
[7] Cao, Y., Jiang, S., Sun, J., Hei, M., Wang, L., Zhang, H., et al. (2021) Assessment of Neonatal Intensive Care Unit Practices, Morbidity, and Mortality among Very Preterm Infants in China. JAMA Network Open, 4, e2118904. [Google Scholar] [CrossRef] [PubMed]
[8] Day, C.L. and Ryan, R.M. (2016) Bronchopulmonary Dysplasia: New Becomes Old Again! Pediatric Research, 81, 210-213. [Google Scholar] [CrossRef] [PubMed]
[9] Naples, R., Ramaiah, S., Rankin, J., Berrington, J. and Harigopal, S. (2021) Life-Threatening Bronchopulmonary Dysplasia: A British Paediatric Surveillance Unit Study. Archives of Disease in ChildhoodFetal and Neonatal Edition, 107, 13-19. [Google Scholar] [CrossRef] [PubMed]
[10] Hintz, S.R., Bann, C.M., Ambalavanan, N., Cotten, C.M., Das, A. and Higgins, R.D. (2010) Predicting Time to Hospital Discharge for Extremely Preterm Infants. Pediatrics, 125, e146-e154. [Google Scholar] [CrossRef] [PubMed]
[11] Harris, C., Lunt, A., Bisquera, A., Peacock, J. and Greenough, A. (2020) Lung Function and Exercise Capacity in Prematurely Born Young People. Pediatric Pulmonology, 55, 2289-2295. [Google Scholar] [CrossRef] [PubMed]
[12] Hennessy, E.M., Bracewell, M.A., Wood, N., Wolke, D., Costeloe, K., Gibson, A., et al. (2008) Respiratory Health in Pre-School and School Age Children Following Extremely Preterm Birth. Archives of Disease in Childhood, 93, 1037-1043. [Google Scholar] [CrossRef] [PubMed]
[13] Balfour-Lynn, I.M., Field, D.J., Gringras, P., Hicks, B., Jardine, E., Jones, R.C., et al. (2009) BTS Guidelines for Home Oxygen in Children. Thorax, 64, ii1-ii26. [Google Scholar] [CrossRef] [PubMed]
[14] Hayes, D., Wilson, K.C., Krivchenia, K., Hawkins, S.M.M., Balfour-Lynn, I.M., Gozal, D., et al. (2019) Home Oxygen Therapy for Children. an Official American Thoracic Society Clinical Practice Guideline. American Journal of Respiratory and Critical Care Medicine, 199, e5-e23. [Google Scholar] [CrossRef] [PubMed]
[15] Ejiawoko, A., Lee, H.C., Lu, T. and Lagatta, J. (2019) Home Oxygen Use for Preterm Infants with Bronchopulmonary Dysplasia in California. The Journal of Pediatrics, 210, 55-62.e1. [Google Scholar] [CrossRef] [PubMed]
[16] Lagatta, J., Murthy, K., Zaniletti, I., Bourque, S., Engle, W., Rose, R., et al. (2020) Home Oxygen Use and 1-Year Readmission among Infants Born Preterm with Bronchopulmonary Dysplasia Discharged from Children’s Hospital Neonatal Intensive Care Units. The Journal of Pediatrics, 220, 40-48.e5. [Google Scholar] [CrossRef] [PubMed]
[17] Kim, J.S., Shim, J.W., Lee, J.H. and Chang, Y.S. (2017) Comparison of Follow-Up Courses after Discharge from Neonatal Intensive Care Unit between Very Low Birth Weight Infants with and without Home Oxygen. Journal of Korean Medical Science, 32, 1295-1303. [Google Scholar] [CrossRef] [PubMed]
[18] DeMauro, S.B., Jensen, E.A., Bann, C.M., Bell, E.F., Hibbs, A.M., Hintz, S.R., et al. (2019) Home Oxygen and 2-Year Outcomes of Preterm Infants with Bronchopulmonary Dysplasia. Pediatrics, 143, e20182956. [Google Scholar] [CrossRef] [PubMed]
[19] Lodha, A., Sauvé, R., Bhandari, V., Tang, S., Christianson, H., Bhandari, A., et al. (2014) Need for Supplemental Oxygen at Discharge in Infants with Bronchopulmonary Dysplasia Is Not Associated with Worse Neurodevelopmental Outcomes at 3 Years Corrected Age. PLOS ONE, 9, e90843. [Google Scholar] [CrossRef] [PubMed]
[20] Lin, H., Chen, X., Ge, J., Shi, L., Du, L. and Ma, X. (2022) Home Oxygen Use and 1-Year Outcome among Preterm Infants with Bronchopulmonary Dysplasia Discharged from a Chinese Regional Nicu. Frontiers in Pediatrics, 10, Article 978743. [Google Scholar] [CrossRef] [PubMed]
[21] Moon, N.M., Mohay, H.A. and Gray, P.H. (2007) Developmental Patterns from 1 to 4 Years of Extremely Preterm Infants Who Required Home Oxygen Therapy. Early Human Development, 83, 209-216. [Google Scholar] [CrossRef] [PubMed]
[22] Aoyama, B.C., Rice, J.L., McGrath-Morrow, S.A. and Collaco, J.M. (2022) Mortality in Outpatients with Bronchopulmonary Dysplasia. The Journal of Pediatrics, 241, 48-53.e1. [Google Scholar] [CrossRef] [PubMed]
[23] Lagatta, J.M., Zhang, L., Yan, K., Dawson, S., Msall, M.E., Ambalavanan, N., et al. (2022) Prospective Risk Stratification Identifies Healthcare Utilization Associated with Home Oxygen Therapy for Infants with Bronchopulmonary Dysplasia. The Journal of Pediatrics, 251, 105-112.e1. [Google Scholar] [CrossRef] [PubMed]
[24] Rhein, L., White, H., Simoneau, T., Traeger, N., Lahiri, T., Kremer, T., et al. (2020) Transmitted Home Oximetry and Duration of Home Oxygen in Premature Infants. Pediatrics, 146, e20200079. [Google Scholar] [CrossRef] [PubMed]
[25] Thébaud, B., Goss, K.N., Laughon, M., Whitsett, J.A., Abman, S.H., Steinhorn, R.H., et al. (2019) Bronchopulmonary Dysplasia. Nature Reviews Disease Primers, 5, Article No. 78. [Google Scholar] [CrossRef] [PubMed]
[26] Greenough, A. (2008) Long-Term Pulmonary Outcome in the Preterm Infant. Neonatology, 93, 324-327. [Google Scholar] [CrossRef] [PubMed]
[27] Sonnenschein-van der Voort, A.M.M., Arends, L.R., de Jongste, J.C., Annesi-Maesano, I., Arshad, S.H., Barros, H., et al. (2014) Preterm Birth, Infant Weight Gain, and Childhood Asthma Risk: A Meta-Analysis of 147,000 European Children. Journal of Allergy and Clinical Immunology, 133, 1317-1329. [Google Scholar] [CrossRef] [PubMed]
[28] Rowe, J. and Jones, L. (2010) Discharge and Beyond. A Longitudinal Study Comparing Stress and Coping in Parents of Preterm Infants. Journal of Neonatal Nursing, 16, 258-266. [Google Scholar] [CrossRef
[29] Lau, R., Crump, R.T., Brousseau, D.C., Panepinto, J.A., Nicholson, M., Engel, J., et al. (2019) Parent Preferences Regarding Home Oxygen Use for Infants with Bronchopulmonary Dysplasia. The Journal of Pediatrics, 213, 30-37.e3. [Google Scholar] [CrossRef] [PubMed]
[30] Ghorbani, M., Dolatian, M., Shams, J. and Alavi-Majd, H. (2014) Anxiety, Post-Traumatic Stress Disorder and Social Supports among Parents of Premature and Full-Term Infants. Iranian Red Crescent Medical Journal, 16, e13461. [Google Scholar] [CrossRef] [PubMed]
[31] Rose, C., Ramsay, L. and Leaf, A. (2008) Strategies for Getting Preterm Infants Home Earlier. Archives of Disease in Childhood, 93, 271-273. [Google Scholar] [CrossRef] [PubMed]
[32] Wilson, E., Nzirawa, T. and Mannan, K. (2020) Quality of Life of Families with Premature Infants on Home Oxygen. Journal of Neonatal Nursing, 26, 49-52. [Google Scholar] [CrossRef
[33] Adama, E.A., Bayes, S. and Sundin, D. (2016) Parents’ Experiences of Caring for Preterm Infants after Discharge from Neonatal Intensive Care Unit: A Meta-Synthesis of the Literature. Journal of Neonatal Nursing, 22, 27-51. [Google Scholar] [CrossRef
[34] McLean, A., Townsend, A., Clark, J., Sawyer, M., Baghurst, P., Haslam, R., et al. (2000) Quality of Life of Mothers and Families Caring for Preterm Infants Requiring Home Oxygen Therapy: A Brief Report. Journal of Paediatrics and Child Health, 36, 440-444. [Google Scholar] [CrossRef] [PubMed]