促甲状腺激素与冠脉病变程度相关性的研究进展

Research Progress of Correlation between Thyroid-Stimulating Hormone and Degree of Coronary Artery Disease

摘要: 近年来，研究者们对甲状腺功能异常与心血管疾病之间的联系进行了深入研究，特别是促甲状腺激素(thyroid-stimulating hormone, TSH)水平与冠脉病变程度之间的相关性。多项研究表明，当患者的TSH水平较高时，其冠脉病变的范围往往更为广泛，且病变的严重程度也可能更为严重。此外，亚临床甲状腺功能减退的患者中，TSH水平与冠脉病变的严重程度存在正相关性，这表明TSH水平可能是冠脉病变程度加重的一个独立危险因素。此外，正常范围内较高水平的TSH与冠脉病变程度加重有关，是预测冠脉病变范围和严重程度的重要生物标志物。年龄、性别、既往病史等多个因素也可能对TSH水平产生影响，需要在评估这些相关性时加以考虑。本文就近些年国内外TSH水平及与冠脉病变程度的研究情况进行综述。

Abstract: In recent years, researchers have conducted in-depth studies on the link between thyroid dysfunction and cardiovascular disease, especially the correlation between thyroid-stimulating hormone (TSH) levels and the degree of coronary artery disease. Multiple studies have shown that when patients have higher TSH levels, the scope of coronary lesions tends to be more extensive, and the severity of the lesions may also be more severe. In addition, in patients with subclinical hypothyroidism, TSH level is positively correlated with the severity of coronary lesions, suggesting that TSH level may be an independent risk factor for the severity of coronary lesions. Besides, a higher level of TSH within the normal range is associated with the severity of coronary lesions, which is an important biomarker for predicting the scope and severity of coronary lesions. Multiple factors such as age, gender, and previous medical history may also have an impact on TSH levels and need to be taken into account when evaluating these correlations. In this paper, the study on TSH level and its relationship with the degree of coronary artery disease was reviewed.