TyG指数与动脉粥样硬化性心血管病(ASCVD)相关性研究
Research on the Correlation between TyG Index and Atherosclerotic Cardiovascular Disease (ASCVD)
摘要: 近年来,甘油三酯葡萄糖(The triglyceride-glucose, TyG)指数在心血管疾病相关研究中备受关注。TyG指数是基于甘油三酯(TG)与空腹血糖(FBG)构建的一个指标,与动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease, ASCVD)有着紧密联系。多项研究发现,TyG指数水平的变化和ASCVD的发生、发展以及预后情况息息相关。本研究旨在对TyG指数与ASCVD相关性的现有研究成果进行梳理总结,为进一步探究二者关系以及提升TyG指数在ASCVD防治中的应用价值提供参考依据。
Abstract: In recent years, the triglyceride-glucose (TyG) index has received extensive attention in cardiovascular disease-related research. The TyG index is an indicator constructed based on triglycerides (TG) and fasting blood glucose (FBG), and it has a close connection with atherosclerotic cardiovascular disease (ASCVD). A number of studies have found that changes in the TyG index level are closely related to the occurrence, development, and prognosis of ASCVD. The aim of this study is to comprehensively review and summarize the existing research results on the correlation between the TyG index and ASCVD, so as to provide a reference basis for further exploring the relationship between the two and enhancing the application value of the TyG index in the prevention and treatment of ASCVD.
文章引用:赵阳阳, 李兴升. TyG指数与动脉粥样硬化性心血管病(ASCVD)相关性研究[J]. 临床医学进展, 2025, 15(1): 1092-1099. https://doi.org/10.12677/acm.2025.151146

参考文献

[1] 刘明波, 何新叶, 杨晓红, 等. 《中国心血管健康与疾病报告2023》要点解读[J]. 中国心血管杂志, 2024, 29(4): 305-324.
[2] Ding, X., Wang, X., Wu, J., Zhang, M. and Cui, M. (2021) Triglyceride-Glucose Index and the Incidence of Atherosclerotic Cardiovascular Diseases: A Meta-Analysis of Cohort Studies. Cardiovascular Diabetology, 20, Article No. 76. [Google Scholar] [CrossRef] [PubMed]
[3] Choi, S. (2019) The Potential Role of Biomarkers Associated with ASCVD Risk: Risk-Enhancing Biomarkers. Journal of Lipid and Atherosclerosis, 8, 173-182. [Google Scholar] [CrossRef] [PubMed]
[4] Vikulova, D.N., Grubisic, M., Zhao, Y., Lynch, K., Humphries, K.H., Pimstone, S.N., et al. (2019) Premature Atherosclerotic Cardiovascular Disease: Trends in Incidence, Risk Factors, and Sex-Related Differences, 2000 to 2016. Journal of the American Heart Association, 8, e12178. [Google Scholar] [CrossRef] [PubMed]
[5] Mahtta, D., Khalid, U., Misra, A., Samad, Z., Nasir, K. and Virani, S.S. (2020) Premature Atherosclerotic Cardiovascular Disease: What Have We Learned Recently? Current Atherosclerosis Reports, 22, Article No. 44. [Google Scholar] [CrossRef] [PubMed]
[6] Wu, S.L., Xu, L.L., Wu, M.Y., et al. (2021) Association between Triglyceride-Glucose Index and Risk of Arterial Stiffness: A Cohort Study. Cardiovascular Diabetology, 20, Article No. 146.
[7] Muniyappa, R., Lee, S., Chen, H. and Quon, M.J. (2008) Current Approaches for Assessing Insulin Sensitivity and Resistance in Vivo: Advantages, Limitations, and Appropriate Usage. American Journal of Physiology-Endocrinology and Metabolism, 294, E15-E26. [Google Scholar] [CrossRef] [PubMed]
[8] Bloomgarden, Z.T. (2006) Measures of Insulin Sensitivity. Clinics in Laboratory Medicine, 26, 611-633. [Google Scholar] [CrossRef] [PubMed]
[9] Hayman, L.L. (2020) Prevention of Atherosclerotic Cardiovascular Disease in Childhood. Current Cardiology Reports, 22, Article No. 86. [Google Scholar] [CrossRef] [PubMed]
[10] Guerrero-Romero, F., Simental-Mendía, L.E., González-Ortiz, M., Martínez-Abundis, E., Ramos-Zavala, M.G., Hernández-González, S.O., et al. (2010) The Product of Triglycerides and Glucose, a Simple Measure of Insulin Sensitivity. Comparison with the Euglycemic-Hyperinsulinemic Clamp. The Journal of Clinical Endocrinology & Metabolism, 95, 3347-3351. [Google Scholar] [CrossRef] [PubMed]
[11] Vasques, A.C.J., Novaes, F.S., de Oliveira, M.d.S., Matos Souza, J.R., Yamanaka, A., Pareja, J.C., et al. (2011) Tyg Index Performs Better than HOMA in a Brazilian Population: A Hyperglycemic Clamp Validated Study. Diabetes Research and Clinical Practice, 93, e98-e100. [Google Scholar] [CrossRef] [PubMed]
[12] Khan, S.H., Sobia, F., Niazi, N.K., Manzoor, S.M., Fazal, N. and Ahmad, F. (2018) Metabolic Clustering of Risk Factors: Evaluation of Triglyceride-Glucose Index (TyG Index) for Evaluation of Insulin Resistance. Diabetology & Metabolic Syndrome, 10, Article No. 74. [Google Scholar] [CrossRef] [PubMed]
[13] Ormazabal, V., Nair, S., Elfeky, O., Aguayo, C., Salomon, C. and Zuñiga, F.A. (2018) Association between Insulin Resistance and the Development of Cardiovascular Disease. Cardiovascular Diabetology, 17, Article No. 122. [Google Scholar] [CrossRef] [PubMed]
[14] Liang, C., Han, S., Senokuchi, T. and Tall, A.R. (2007) The Macrophage at the Crossroads of Insulin Resistance and Atherosclerosis. Circulation Research, 100, 1546-1555. [Google Scholar] [CrossRef] [PubMed]
[15] Chen, X., Zhao, J., Cai, Q., Chen, R., Wu, W., Wang, P., et al. (2023) Relationship between Coronary Artery Calcium Score and Coronary Stenosis. Cardiology Research and Practice, 2023, Article ID: 5538111. [Google Scholar] [CrossRef] [PubMed]
[16] Shiga, Y., Tashiro, K., Miura, E., Higashi, S., Kawahira, Y., Kuwano, T., et al. (2023) Association between Major Adverse Cardiovascular Events and the Gensini Score or Coronary Artery Calcification Score in Hypertensive Patients Who Have Undergone Coronary Computed Tomography Angiography. Cardiology Research, 14, 91-96. [Google Scholar] [CrossRef] [PubMed]
[17] Wang, J., Huang, X., Fu, C., Sheng, Q. and Liu, P. (2022) Association between Triglyceride Glucose Index, Coronary Artery Calcification and Multivessel Coronary Disease in Chinese Patients with Acute Coronary Syndrome. Cardiovascular Diabetology, 21, Article No. 187. [Google Scholar] [CrossRef] [PubMed]
[18] Su, J., Li, Z., Huang, M., Wang, Y., Yang, T., Ma, M., et al. (2022) Triglyceride Glucose Index for the Detection of the Severity of Coronary Artery Disease in Different Glucose Metabolic States in Patients with Coronary Heart Disease: A RCSCD-TCM Study in China. Cardiovascular Diabetology, 21, Article No. 96. [Google Scholar] [CrossRef] [PubMed]
[19] Liang, S., Wang, C., Zhang, J., Liu, Z., Bai, Y., Chen, Z., et al. (2023) Triglyceride-Glucose Index and Coronary Artery Disease: A Systematic Review and Meta-Analysis of Risk, Severity, and Prognosis. Cardiovascular Diabetology, 22, Article No. 170. [Google Scholar] [CrossRef] [PubMed]
[20] Katz, P., Leiter, L.A., Mellbin, L. and Rydén, L. (2014) The Clinical Burden of Type 2 Diabetes in Patients with Acute Coronary Syndromes: Prognosis and Implications for Short-and Long-Term Management. Diabetes and Vascular Disease Research, 11, 395-409. [Google Scholar] [CrossRef] [PubMed]
[21] Tian, X., Zuo, Y., Chen, S., Liu, Q., Tao, B., Wu, S., et al. (2021) Triglyceride-Glucose Index Is Associated with the Risk of Myocardial Infarction: An 11-Year Prospective Study in the Kailuan Cohort. Cardiovascular Diabetology, 20, Article No. 19. [Google Scholar] [CrossRef] [PubMed]
[22] Wang, W., Yang, J., Wang, K., Niu, J., Liu, Y. and Ge, H. (2024) Association between the Triglyceride-Glucose Index and In-Hospital Major Adverse Cardiovascular Events in Patients with Acute Coronary Syndrome: Results from the Improving Care for Cardiovascular Disease in China (CCC)-Acute Coronary Syndrome Project. Cardiovascular Diabetology, 23, Article No. 170. [Google Scholar] [CrossRef] [PubMed]
[23] Liu, N., Liu, C., Qu, Z. and Tan, J. (2022) Association between the Triglyceride–glucose Index and Chronic Kidney Disease in Adults. International Urology and Nephrology, 55, 1279-1289. [Google Scholar] [CrossRef] [PubMed]
[24] Gao, Y.M., Chen, W.J., Deng, Z.L., et al. (2023) Association between Triglyceride-Glucose Index and Risk of End-Stage Renal Disease in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease. Frontiers in Endocrinology, 14, Article 1150980.
[25] Luo, J.W., Duan, W.H., Yu, Y.Q., et al. (2021) Prognostic Significance of Triglyceride-Glucose Index for Adverse Cardiovascular Events in Patients with Coronary Artery Disease: A Systematic Review and Meta-Analysis. Frontiers in Cardiovascular Medicine, 8, Article 774781.
[26] Loh, H.C., Lim, R., Lee, K.W., Ooi, C.Y., Chuan, D.R., Looi, I., et al. (2020) Effects of Vitamin E on Stroke: A Systematic Review with Meta-Analysis and Trial Sequential Analysis. Stroke and Vascular Neurology, 6, 109-120. [Google Scholar] [CrossRef] [PubMed]
[27] Yang, Y., Huang, X., Wang, Y., Leng, L., Xu, J., Feng, L., et al. (2023) The Impact of Triglyceride-Glucose Index on Ischemic Stroke: A Systematic Review and Meta-Analysis. Cardiovascular Diabetology, 22, Article No. 2. [Google Scholar] [CrossRef] [PubMed]
[28] Wang, X., Feng, B., Huang, Z., Cai, Z., Yu, X., Chen, Z., et al. (2022) Relationship of Cumulative Exposure to the Triglyceride-Glucose Index with Ischemic Stroke: A 9-Year Prospective Study in the Kailuan Cohort. Cardiovascular Diabetology, 21, Article No. 66. [Google Scholar] [CrossRef] [PubMed]
[29] Huang, Z., Ding, X., Yue, Q., Wang, X., Chen, Z., Cai, Z., et al. (2022) Triglyceride-Glucose Index Trajectory and Stroke Incidence in Patients with Hypertension: A Prospective Cohort Study. Cardiovascular Diabetology, 21, Article No. 141. [Google Scholar] [CrossRef] [PubMed]
[30] Wang, J., Tang, H., Wang, X., Wu, J., Gao, J., Diao, S., et al. (2023) Association of Triglyceride-Glucose Index with Early Neurological Deterioration Events in Patients with Acute Ischemic Stroke. Diabetology & Metabolic Syndrome, 15, Article No. 112. [Google Scholar] [CrossRef] [PubMed]
[31] Wang, Y., Liu, T., Li, Y., Zhang, K., Fan, H., Ren, J., et al. (2023) Triglyceride-Glucose Index, Symptomatic Intracranial Artery Stenosis and Recurrence Risk in Minor Stroke Patients with Hypertension. Cardiovascular Diabetology, 22, Article No. 90. [Google Scholar] [CrossRef] [PubMed]
[32] Lu, Y., Pechlaner, R., Cai, J., Yuan, H., Huang, Z., Yang, G., et al. (2020) Trajectories of Age-Related Arterial Stiffness in Chinese Men and Women. Journal of the American College of Cardiology, 75, 870-880. [Google Scholar] [CrossRef] [PubMed]
[33] Song, P., Rudan, D., Zhu, Y., Fowkes, F.J.I., Rahimi, K., Fowkes, F.G.R., et al. (2019) Global, Regional, and National Prevalence and Risk Factors for Peripheral Artery Disease in 2015: An Updated Systematic Review and Analysis. The Lancet Global Health, 7, e1020-e1030. [Google Scholar] [CrossRef] [PubMed]
[34] Hirsch, A.T. (2001) Peripheral Arterial Disease Detection, Awareness, and Treatment in Primary Care. JAMA, 286, 1317-1324. [Google Scholar] [CrossRef] [PubMed]
[35] Caliskan, S. and Boyuk, F. (2023) Is Triglyceride-Glucose Index a Valuable Parameter in Peripheral Artery Disease? Cureus, 15, e35532. [Google Scholar] [CrossRef] [PubMed]
[36] Ji, W.J., Lan, G., Sun, P.F., et al. (2022) Association of the Triglyceride-Glucose Index and Vascular Target Organ Damage in a Beijing Community-Based Population. Frontiers in Cardiovascular Medicine, 9, Article 948402.
[37] Li, M.H., Zhan, A.H., Huang, X., et al. (2020) Positive Association between Triglyceride Glucose Index and Arterial Stiffness in Hypertensive Patients: The China H-Type Hypertension Registry Study. Cardiovascular Diabetology, 19, Article No. 139.
[38] Guo, W., Zhu, W., Wu, J., Li, X., Lu, J., Qin, P., et al. (2021) Triglyceride Glucose Index Is Associated with Arterial Stiffness and 10-Year Cardiovascular Disease Risk in a Chinese Population. Frontiers in Cardiovascular Medicine, 8, Article 585776. [Google Scholar] [CrossRef] [PubMed]
[39] Samavarchitehrani, A., Cannavo, A., Behnoush, A.H., Kazemi Abadi, A., Shokri Varniab, Z. and Khalaji, A. (2024) Investigating the Association between the Triglyceride-Glucose Index and Peripheral Artery Disease: A Systematic Review and Meta-Analysis. Nutrition & Diabetes, 14, Article No. 80. [Google Scholar] [CrossRef] [PubMed]
[40] Gao, J., Hao, Q., Gao, M., Zhang, K., Li, X., Wang, J., et al. (2021) Triglyceride-glucose Index in the Development of Peripheral Artery Disease: Findings from the Atherosclerosis Risk in Communities (ARIC) Study. Cardiovascular Diabetology, 20, Article No. 126. [Google Scholar] [CrossRef] [PubMed]