ER、TGF-β1和CD138在子宫内膜息肉组织中的表达及临床意义

Expression of ER, TGF-β1 and CD138 in Endometrial Polyps and Their Clinical Significance

摘要: 目的：探究雌激素受体(ER)、转化生长因子β1 (TGF-β1)和膜硫酸乙酰肝素蛋白多糖配体蛋白聚糖-1 (CD138)在子宫内膜息肉(EP)组织中的表达及与临床参数的相关性分析。方法：收集了于2024年1月~4月在湘西州自治州人民医院就诊的子宫内膜息肉患者46例作为息肉组。在对照组中，我们纳入了44例同期因不孕症、异常子宫出血或绝经后出血而接受宫腔镜检查的患者，采取免疫组化法测定ER、TGF-β1和CD138在两组内的表达情况。结果：息肉组中ER、CD138和TGF-β1的阳性表达率显著高于对照组(P < 0.05)，差异有统计学意义(P < 0.05)。ER、CD138和TGF-β1的阳性表达与相关的临床参数(患者年龄、BMI、孕次、产次、流产次数、所处分期、是否有剖宫产史、是否有异常子宫出血或绝经后出血)的差异均无统计学差异(P > 0.05)。结论：EP组织中ER、CD138和TGF-β1均呈高表达，可能与EP的发生与发展密切相关。

Abstract: Objective: To investigate the expression of estrogen receptor (ER), transforming growth factor-β1 (TGF-β1), and membrane heparan sulfate proteoglycan ligand proteoglycan-1 (CD138) in endometrial polyps (EP) tissues and to analyze their relationship with clinical parameters. Methods: We collected 46 endometrial polyp patients from the People’s Hospital of the Autonomous Prefecture of Xiangxi between January and April 2024, forming the EP group. The control group consisted of 44 additional patients who required hysteroscopy because of infertility, abnormal uterine bleeding or postmenopausal bleeding. Immunohistochemistry was used to compare the expression of ER, TGF-β1, and CD138 in the two groups. Results: The positive expression rates of ER, CD138 and TGF-β1 in the polyp group were significantly higher than those in the control group (P < 0.05). The positive expression of ER, CD138 and TGF-β1 in relation to no statistically significant differences was observed in the clinical parameters (patient age, BMI, gestation, delivery, number of miscarriages, phase of the menstrual cycle, history of caesarean section, abnormal uterine bleeding or postmenopausal bleeding) between the two groups (P > 0.05). Conclusions: The expression of ER, CD138 and TGF-β1 was markedly elevated in EP tissues, suggesting a potential correlation with the aetiology and progression of EP.