宫颈低级别鳞状上皮内病变合并高危型HPV感染治疗进展

Progress in the Treatment of Cervical Low-Grade Squamous Intraepithelial Lesion Combined with High-Risk HPV Infection

摘要: 宫颈癌(Cervical Cancer)是我国最常见的妇科肿瘤，目前认为宫颈癌的发生发展，是因为宫颈上皮内病变继续发展，突破上皮下基底膜，浸润间质，形成了宫颈浸润癌。宫颈低级别鳞状上皮内病变大部分患者可以自然消退，在极少数个体中，长期的高危型HPV感染可能促使宫颈发展至高级别鳞状上皮内病变，并有可能最终演变为宫颈癌。针对合并高危型HPV感染的宫颈低级别鳞状上皮内病变，当前的治疗方案包括药物治疗、物理疗法和手术切除等多种方法。临床可根据患者年龄、生育诉求及实际病情和经济状况，选择合适的治疗方案。本文对宫颈低级别鳞状上皮内病变合并高危型HPV感染的治疗策略进行综述，对于临床指导实践具有重要意义。

Abstract: Cervical cancer is the most common gynecological tumor in our country. It is currently believed that the occurrence and development of cervical cancer are a process where cervical intraepithelial neoplasia progresses, breaks through the basement membrane under the epithelium, infiltrates the stroma, and forms invasive cervical cancer. Most patients with low-grade squamous intraepithelial lesions (LSIL) of the cervix can naturally regress. In a very small number of individuals, long-term high-risk HPV infection may promote the progression of the cervix to high-grade squamous intraepithelial lesions (HSIL) and potentially evolve into cervical cancer. For low-grade squamous intraepithelial lesions of the cervix associated with high-risk HPV infection, current treatment options include drug therapy, physical therapy, and surgical excision, among various methods. Clinically, appropriate treatment plans can be selected based on the patient’s age, fertility desires, actual condition, and economic status. This article reviews the treatment strategies for low-grade squamous intraepithelial lesions of the cervix combined with high-risk HPV infection, which is of significant importance for guiding clinical practice.