晚期糖基化终产物受体在心血管疾病中的研究进展
Research Progress on the Receptor of Advanced Glycation End Products in Cardiovascular Diseases
DOI: 10.12677/acm.2025.151217, PDF,   
作者: 何 端, 王星玉, 杨萌甜, 王 丹：延安大学医学院，陕西 延安；西安市中心医院心血管内科，陕西 西安；潘军强, 马 锋：西安市中心医院心血管内科，陕西 西安
关键词: 晚期糖基化终产物受体；高血压；冠状动脉扩张；主动脉瓣狭窄；心房颤动；心力衰竭；Receptor of Advanced Glycation End Products； Hypertension； Coronary Artery Ectasias； Aortic Stenosis； Atrial Fibrillation； Heart Failure
摘要: 晚期糖基化终产物受体可激活多种信号传导通路，并与多种配体相互作用，通过激活氧化应激反应及增加活性氧的产生，参与炎症反应及血栓形成等多种病理反应。以上机制与糖尿病血管并发症、心血管疾病、阿尔茨海默病、癌症生长和转移、胰岛素抵抗和非酒精性脂肪肝在内的多种疾病的发生发展相关。本综述系统总结了RAGE在多种心血管疾病中的作用机制，并梳理了RAGE作为治疗靶点的研究进展，为未来心血管疾病的防治提供了新的治疗思路。
Abstract: The receptor of advanced glycation end products can activate a variety of signal transduction pathways and interact with a variety of ligands, participating in various pathological reactions such as inflammation and thrombosis by activating oxidative stress response and increasing the production of reactive oxygen species. These mechanisms are associated with the occurrence and development of many diseases, including vascular complications of diabetes, cardiovascular disease, Alzheimer’s disease, cancer growth and metastasis, insulin resistance and non-alcoholic fatty liver disease. This review systematically summarizes the mechanism of RAGE in a variety of cardiovascular diseases, and reviews the research progress of RAGE as a therapeutic target, providing a new therapeutic idea for the prevention and treatment of cardiovascular diseases in the future.
文章引用：何端, 王星玉, 杨萌甜, 王丹, 潘军强, 马锋. 晚期糖基化终产物受体在心血管疾病中的研究进展[J]. 临床医学进展, 2025, 15(1): 1620-1626. https://doi.org/10.12677/acm.2025.151217

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