沙门氏菌耐药性的研究进展
Research Progress on Antimicrobial Resistance of Salmonella
DOI: 10.12677/acm.2025.151220, PDF,   
作者: 杨君涵, 张晓兵*：重庆医科大学附属第一医院医学检验科，重庆
关键词: 沙门氏菌；耐药性；多重耐药；耐药机制；Salmonella； Antimicrobial Resistance； Multidrug Resistance； Mechanisms of Drug Resistance
摘要: 沙门氏菌是最常见的食源性致病菌之一，对公共卫生构成了严重威胁。近年来沙门氏菌耐药性呈上升趋势，同时多重耐药菌株的增加也给临床治疗带来了巨大困难，这已成为全球公共卫生面临的一个重大挑战。本文综述了沙门氏菌的耐药机制、耐药性的分布和趋势，以及耐药性的防控策略，旨在增强对沙门氏菌耐药性问题的认识，为控制感染、防止耐药菌的传播以及制定合适的治疗方案提供科学依据。
Abstract: Salmonella is one of the most common foodborne pathogens, posing a severe threat to public health. In recent years, the antimicrobial resistance of Salmonella has been increasing, and the rise in multidrug-resistant strains has also posed significant challenges to clinical treatment. This has become a major challenge facing global public health. This article reviews the mechanisms of drug resistance in Salmonella, the distribution and trends of antimicrobial resistance, and strategies for the prevention and control of antimicrobial resistance in salmonella. It aims to enhance the understanding of the issue of Salmonella resistance and provide a scientific basis for controlling infections, preventing the spread of resistant strains, and developing appropriate treatment plans.
文章引用：杨君涵, 张晓兵. 沙门氏菌耐药性的研究进展[J]. 临床医学进展, 2025, 15(1): 1639-1645. https://doi.org/10.12677/acm.2025.151220

参考文献

[1] Duff, N., Steele, A.D. and Garrett, D. (2020) Global Action for Local Impact: The 11th International Conference on Typhoid and Other Invasive Salmonelloses. Clinical Infectious Diseases, 71, S59-S63. [Google Scholar] [CrossRef] [PubMed]
[2] Chiou, C., Hong, Y., Wang, Y., Chen, B., Teng, R., Song, H., et al. (2023) Microbiology Spectrum, 11, e03364-22. [Google Scholar] [CrossRef] [PubMed]
[3] Aleksandrowicz, A., Carolak, E., Dutkiewicz, A., Błachut, A., Waszczuk, W. and Grzymajlo, K. (2023) Better Together—Salmonella Biofilm-Associated Antibiotic Resistance. Gut Microbes, 15, Article 2229937. [Google Scholar] [CrossRef] [PubMed]
[4] Michael, G.B. and Schwarz, S. (2016) Antimicrobial Resistance in Zoonotic Nontyphoidal Salmonella: An Alarming Trend? Clinical Microbiology and Infection, 22, 968-974. [Google Scholar] [CrossRef] [PubMed]
[5] Crump, J.A., Sjölund-Karlsson, M., Gordon, M.A. and Parry, C.M. (2015) Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections. Clinical Microbiology Reviews, 28, 901-937. [Google Scholar] [CrossRef] [PubMed]
[6] Threlfall, E.J. (2002) Antimicrobial Drug Resistance in Salmonella: Problems and Perspectives in Food-and Water-Borne Infections. FEMS Microbiology Reviews, 26, 141-148. [Google Scholar] [CrossRef] [PubMed]
[7] Chiu, C., Lee, J., Wang, M. and Chu, C. (2021) Genetic Analysis and Plasmid-Mediated blaCMY-2 in Salmonella and Shigella and the Ceftriaxone Susceptibility Regulated by the ISEcp-1 tnpA-blaCMY-2-blc-sugE. Journal of Microbiology, Immunology and Infection, 54, 649-657. [Google Scholar] [CrossRef] [PubMed]
[8] Hiley, L., Graham, R.M.A. and Jennison, A.V. (2021) Characterisation of Inci1 Plasmids Associated with Change of Phage Type in Isolates of Salmonella enterica Serovar Typhimurium. BMC Microbiology, 21, Article No. 92. [Google Scholar] [CrossRef] [PubMed]
[9] Wang, Y., Liu, Y., Lyu, N., Li, Z., Ma, S., Cao, D., et al. (2022) The Temporal Dynamics of Antimicrobial-Resistant Salmonella enterica and Predominant Serovars in China. National Science Review, 10, nwac269. [Google Scholar] [CrossRef] [PubMed]
[10] Correia, S., Poeta, P., Hébraud, M., Capelo, J.L. and Igrejas, G. (2017) Mechanisms of Quinolone Action and Resistance: Where Do We Stand? Journal of Medical Microbiology, 66, 551-559. [Google Scholar] [CrossRef] [PubMed]
[11] Redgrave, L.S., Sutton, S.B., Webber, M.A. and Piddock, L.J.V. (2014) Fluoroquinolone Resistance: Mechanisms, Impact on Bacteria, and Role in Evolutionary Success. Trends in Microbiology, 22, 438-445. [Google Scholar] [CrossRef] [PubMed]
[12] Aldred, K.J., Kerns, R.J. and Osheroff, N. (2014) Mechanism of Quinolone Action and Resistance. Biochemistry, 53, 1565-1574. [Google Scholar] [CrossRef] [PubMed]
[13] Drlica, K., Malik, M., Kerns, R.J. and Zhao, X. (2008) Quinolone-Mediated Bacterial Death. Antimicrobial Agents and Chemotherapy, 52, 385-392. [Google Scholar] [CrossRef] [PubMed]
[14] Cuypers, W.L., Jacobs, J., Wong, V., Klemm, E.J., Deborggraeve, S. and Van Puyvelde, S. (2018) Fluoroquinolone Resistance in Salmonella: Insights by Whole-Genome Sequencing. Microbial Genomics, 4, e000195. [Google Scholar] [CrossRef] [PubMed]
[15] Nordmann, P., Dortet, L. and Poirel, L. (2012) Carbapenem Resistance in Enterobacteriaceae: Here Is the Storm! Trends in Molecular Medicine, 18, 263-272. [Google Scholar] [CrossRef] [PubMed]
[16] Fernández, J., Guerra, B. and Rodicio, M. (2018) Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food. Veterinary Sciences, 5, Article 40. [Google Scholar] [CrossRef] [PubMed]
[17] Martínez-Martínez, L. (2008) Extended-Spectrum β-Lactamases and the Permeability Barrier. Clinical Microbiology and Infection, 14, 82-89. [Google Scholar] [CrossRef] [PubMed]
[18] Pitout, J.D.D., Nordmann, P. and Poirel, L. (2015) Carbapenemase-Producing Klebsiella pneumoniae, a Key Pathogen Set for Global Nosocomial Dominance. Antimicrobial Agents and Chemotherapy, 59, 5873-5884. [Google Scholar] [CrossRef] [PubMed]
[19] Patel, G. and Bonomo, R.A. (2013) “Stormy Waters Ahead”: Global Emergence of Carbapenemases. Frontiers in Microbiology, 4, Article 48. [Google Scholar] [CrossRef] [PubMed]
[20] Potter, R.F., D’Souza, A.W. and Dantas, G. (2016) The Rapid Spread of Carbapenem-Resistant Enterobacteriaceae. Drug Resistance Updates, 29, 30-46. [Google Scholar] [CrossRef] [PubMed]
[21] Rozwandowicz, M., Brouwer, M.S.M., Fischer, J., Wagenaar, J.A., Gonzalez-Zorn, B., Guerra, B., et al. (2018) Plasmids Carrying Antimicrobial Resistance Genes in Enterobacteriaceae. Journal of Antimicrobial Chemotherapy, 73, 1121-1137. [Google Scholar] [CrossRef] [PubMed]
[22] Threlfall, E.J., Fisher, I.S.T., Berghold, C., Gerner-Smidt, P., Tschäpe, H., Cormican, M., et al. (2003) Antimicrobial Drug Resistance in Isolates of Salmonella enterica from Cases of Salmonellosis in Humans in Europe in 2000: Results of International Multi-Centre Surveillance. Eurosurveillance, 8, 41-45. [Google Scholar] [CrossRef] [PubMed]
[23] Yang, C., Xiang, Y. and Qiu, S. (2023) Resistance in Enteric Shigella and Nontyphoidal Salmonella: Emerging Concepts. Current Opinion in Infectious Diseases, 36, 360-365. [Google Scholar] [CrossRef] [PubMed]
[24] Cao, G., Zhao, S., Kuang, D., Hsu, C., Yin, L., Luo, Y., et al. (2023) Geography Shapes the Genomics and Antimicrobial Resistance of Salmonella enterica Serovar Enteritidis Isolated from Humans. Scientific Reports, 13, Article No. 1331. [Google Scholar] [CrossRef] [PubMed]
[25] 华德, 王鲁彦, 邝仕壮, 等. 2020年海南省人源沙门菌耐药性及携带耐药基因分析[J]. 疾病监测, 2023, 38(6): 722-728.
[26] 郑之北, 郑伟, 汪皓秋, 等. 杭州地区多重耐药沙门氏菌的耐药特征[J]. 微生物学通报, 2021, 48(2): 536-544.
[27] Wei, X., Long, L., You, L., Wang, M., Wang, D., Liu, C., et al. (2023) Serotype Distribution, Trend of Multidrug Resistance and Prevalence of β-Lactamase Resistance Genes in Human Salmonella Isolates from Clinical Specimens in Guizhou, China. PLOS ONE, 18, e0282254. [Google Scholar] [CrossRef] [PubMed]
[28] Wang, Y., Xu, X., Zhu, B., Lyu, N., Liu, Y., Ma, S., et al. (2023) Genomic Analysis of Almost 8,000 Salmonella Genomes Reveals Drivers and Landscape of Antimicrobial Resistance in China. Microbiology Spectrum, 11, e02080-23. [Google Scholar] [CrossRef] [PubMed]
[29] Talukder, H., Roky, S.A., Debnath, K., Sharma, B., Ahmed, J. and Roy, S. (2023) Prevalence and Antimicrobial Resistance Profile of Salmonella Isolated from Human, Animal and Environment Samples in South Asia: A 10-Year Meta-Analysis. Journal of Epidemiology and Global Health, 13, 637-652. [Google Scholar] [CrossRef] [PubMed]
[30] Montone, A.M.I., Cutarelli, A., Peruzy, M.F., La Tela, I., Brunetti, R., Pirofalo, M.G., et al. (2023) Antimicrobial Resistance and Genomic Characterization of Salmonella Infantis from Different Sources. International Journal of Molecular Sciences, 24, Article 5492. [Google Scholar] [CrossRef] [PubMed]
[31] Cuypers, W.L., Jacobs, J., Wong, V., Klemm, E.J., Deborggraeve, S. and Van Puyvelde, S. (2018) Fluoroquinolone Resistance in Salmonella: Insights by Whole-Genome Sequencing. Microbial Genomics, 4, e000195. [Google Scholar] [CrossRef] [PubMed]
[32] Miriagou, V., Tzouvelekis, L.S., Rossiter, S., Tzelepi, E., Angulo, F.J. and Whichard, J.M. (2003) Imipenem Resistance in a Salmonella Clinical Strain Due to Plasmid-Mediated Class A Carbapenemase KPC-2. Antimicrobial Agents and Chemotherapy, 47, 1297-1300. [Google Scholar] [CrossRef] [PubMed]
[33] Le Hello, S., Harrois, D., Bouchrif, B., Sontag, L., Elhani, D., Guibert, V., et al. (2013) Highly Drug-Resistant Salmonella enterica Serotype Kentucky ST198-X1: A Microbiological Study. The Lancet Infectious Diseases, 13, 672-679. [Google Scholar] [CrossRef] [PubMed]
[34] Nordmann, P., Poirel, L., Mak, J.K., White, P.A., McIver, C.J. and Taylor, P. (2008) Multidrug-Resistant Salmonella Strains Expressing Emerging Antibiotic Resistance Determinants. Clinical Infectious Diseases, 46, 324-325. [Google Scholar] [CrossRef] [PubMed]
[35] Huang, J., Wang, M., Ding, H., Ye, M., Hu, F., Guo, Q., et al. (2013) New Delhi Metallo-β-Lactamase-1 in Carbapenem-Resistant Salmonella Strain, China. Emerging Infectious Diseases, 19, 2049-2051. [Google Scholar] [CrossRef] [PubMed]
[36] Day, M.R., Meunier, D., Doumith, M., de Pinna, E., Woodford, N. and Hopkins, K.L. (2015) Carbapenemase-Producing Salmonella enterica Isolates in the UK. Journal of Antimicrobial Chemotherapy, 70, 2165-2167. [Google Scholar] [CrossRef] [PubMed]
[37] Irfan, S., Khan, E., Jabeen, K., Bhawan, P., Hopkins, K.L., Day, M., et al. (2015) Clinical Isolates of Salmonella enterica Serovar Agona Producing NDM-1 Metallo-Β-Lactamase: First Report from Pakistan. Journal of Clinical Microbiology, 53, 346-348. [Google Scholar] [CrossRef] [PubMed]
[38] Shen, H., Chen, H., Ou, Y., Huang, T., Chen, S., Zhou, L., et al. (2020) Prevalence, Serotypes, and Antimicrobial Resistance of Salmonella Isolates from Patients with Diarrhea in Shenzhen, China. BMC Microbiology, 20, Article No. 197. [Google Scholar] [CrossRef] [PubMed]
[39] Fischer, J., Rodríguez, I., Schmoger, S., Friese, A., Roesler, U., Helmuth, R., et al. (2012) Salmonella enterica Subsp. Enterica Producing VIM-1 Carbapenemase Isolated from Livestock Farms. Journal of Antimicrobial Chemotherapy, 68, 478-480. [Google Scholar] [CrossRef] [PubMed]
[40] Wang, W., Baloch, Z., Peng, Z., Hu, Y., Xu, J., Fanning, S., et al. (2017) Genomic Characterization of a Large Plasmid Containing a blaNDM-1 Gene Carried on Salmonella enterica Serovar Indiana C629 Isolate from China. BMC Infectious Diseases, 17, Article No. 479. [Google Scholar] [CrossRef] [PubMed]
[41] Villa, L., Guerra, B., Schmoger, S., Fischer, J., Helmuth, R., Zong, Z., et al. (2015) IncA/C Plasmid Carrying blaNDM-1, blaCMY-16, and fosA3 in a Salmonella enterica Serovar Corvallis Strain Isolated from a Migratory Wild Bird in Germany. Antimicrobial Agents and Chemotherapy, 59, 6597-6600. [Google Scholar] [CrossRef] [PubMed]
[42] Mollenkopf, D.F., Stull, J.W., Mathys, D.A., Bowman, A.S., Feicht, S.M., Grooters, S.V., et al. (2017) Carbapenemase-Producing Enterobacteriaceae Recovered from the Environment of a Swine Farrow-to-Finish Operation in the United States. Antimicrobial Agents and Chemotherapy, 61. [Google Scholar] [CrossRef] [PubMed]
[43] Tennant, S.M., Schmidlein, P., Simon, R., Pasetti, M.F., Galen, J.E. and Levine, M.M. (2015) Refined Live Attenuated Salmonella enterica Serovar Typhimurium and Enteritidis Vaccines Mediate Homologous and Heterologous Serogroup Protection in Mice. Infection and Immunity, 83, 4504-4512. [Google Scholar] [CrossRef] [PubMed]
[44] Higginson, E.E., Ramachandran, G., Panda, A., Shipley, S.T., Kriel, E.H., DeTolla, L.J., et al. (2018) Improved Tolerability of a Salmonella enterica Serovar Typhimurium Live-Attenuated Vaccine Strain Achieved by Balancing Inflammatory Potential with Immunogenicity. Infection and Immunity, 86. [Google Scholar] [CrossRef] [PubMed]
[45] Matsui, H., Suzuki, M., Isshiki, Y., Kodama, C., Eguchi, M., Kikuchi, Y., et al. (2003) Oral Immunization with ATP-Dependent Protease-Deficient Mutants Protects Mice against Subsequent Oral Challenge with Virulent Salmonella enterica Serovar Typhimurium. Infection and Immunity, 71, 30-39. [Google Scholar] [CrossRef] [PubMed]
[46] Allam, U.S., Krishna, M.G., Lahiri, A., Joy, O. and Chakravortty, D. (2011) Salmonella enterica Serovar Typhimurium Lacking hfq Gene Confers Protective Immunity against Murine Typhoid. PLOS ONE, 6, e16667. [Google Scholar] [CrossRef] [PubMed]
[47] Angelakopoulos, H. and Hohmann, E.L. (2000) Pilot Study of PhoP/PhoQ-Deleted Salmonella enterica Serovar Typhimurium Expressing Helicobacter pylori Urease in Adult Volunteers. Infection and Immunity, 68, 2135-2141. [Google Scholar] [CrossRef] [PubMed]
[48] Martin, L.B., Tack, B., Marchello, C.S., Sikorski, M.J., Owusu-Dabo, E., Nyirenda, T., et al. (2024) Vaccine Value Profile for Invasive Non-Typhoidal Salmonella Disease. Vaccine, 42, S101-S124. [Google Scholar] [CrossRef] [PubMed]

为你推荐