转化生长因子-β在结直肠癌发生发展中的双重作用
The Dual Role of Transforming Growth Factor-β in the Occurrence and Development of Colorectal Cancer
DOI: 10.12677/acm.2025.151221, PDF,    科研立项经费支持
作者: 黄思璐, 李佳琪, 李 娟, 李心弋, 徐 洋, 罗顺莉：湖南医药学院医学检验学院，湖南 怀化
关键词: 转化生长因子-β；结直肠癌；双重作用；Transforming Growth Factor-Beta； Colorectal Cancer； Dual Role
摘要: 转化生长因子-β (Transforming growth factor-beta, TGF-β)作为一种细胞因子，隶属于TGF-β超家族，它在细胞生长和分化过程中担任着关键的调节角色。近年来许多研究表明TGF-β在结直肠癌发生和发展过程中的作用具有两面性，它既有可以促进肿瘤的生长和转移，也有可以在某些特定情况下通过抑制TGF-β的活性来增强结直肠癌的治疗效果。本文旨在综述近年来TGF-β在结直肠癌发生和发展过程中的双重作用及潜在的机制，以期为结直肠癌的治疗提供参考依据。
Abstract: Transforming growth factor-beta (TGF-β), a cytokine belonging to the TGF-β superfamily, plays a key regulatory role in the process of cell growth and differentiation. In recent years, many studies have shown that the role of TGF-β in the occurrence and development of colorectal cancer has two sides, which can promote the growth and metastasis of tumors, and can enhance the therapeutic effect of colorectal cancer by inhibiting the activity of TGF-β in some specific cases. This article aims to review the dual role of TGF-β in the occurrence and development of colorectal cancer in recent years and its potential mechanism, in order to provide a reference for the treatment of colorectal cancer.
文章引用：黄思璐, 李佳琪, 李娟, 李心弋, 徐洋, 罗顺莉. 转化生长因子-β在结直肠癌发生发展中的双重作用[J]. 临床医学进展, 2025, 15(1): 1646-1653. https://doi.org/10.12677/acm.2025.151221

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