二期梅毒患者外周血IL-6和CRP的检测及意义

Detection and Significance of IL-6 and CRP in Peripheral Blood of Patients with Second-Stage Syphilis

摘要: 目的：探讨二期梅毒患者治疗前外周血中白细胞介素-6 (IL-6)和C反应蛋白(CRP)水平的相关性。方法：选择自2022年10月到2024年3月期间山西省汾阳医院收治的220例二期梅毒患者，对其进行回顾性分析。采用电化学发光法检测IL-6和CRP的表达水平，以甲苯胺红不加热血清素试验(TRUST)的不同滴度为依据，对其进行了分组，将TRUST滴度 ≤ 1:4的分为低滴度组，将TRUST滴度 > 1:4的分为高滴度组，其中，低滴度组54例，高滴度组166例，分析各组中IL-6与CRP的表达及相关性。结果：TRUST高滴度的患者CRP和IL-6的表达水平均高于低滴度的患者，均有统计学意义(P < 0.05)，且二期梅毒患者外周血中CRP和IL-6的表达具有相关性(r² = 0.823)。结论：二期梅毒患者外周血中的CRP和IL-6的表达水平具有相关性，二者与TRUST滴度联合检查，更有利于提高二期梅毒患者的疗效监控力度。

Abstract: Objective: To investigate the relationships between interleukin (IL-6) and C-reactive protein (CRP) levels in the peripheral blood of patients with stage II syphilis before treatment. Methods: 220 patients with second-stage syphilis admitted to Shanxi Fenyang Hospital between October 2021 and March 2023 were retrospectively selected and analysed. Determination of IL-6 and CRP expression levels by electrochemiluminescence which grouped by differences in Toluidine Red Intact Serum Test (TRUST) titer. TRUST titers ≤ 1:4 were divided into low titer groups and TRUST titers > 1:4 into high titer groups. Of these, 54 were in the low-test group and 166 in the high-test group. IL-6 and CRP expression and correlation were analysed in each group. Results: Patients with high TRUST titers had higher CRP and IL-6 levels than patients with low titers, these differences were statistically significant (P < 0.05). And CRP and IL-6 are correlated (Correlation coefficient of 0.823). Conclusion: Correlation between CRP and IL-6 have expression in patients with stage II syphilis. The two together with TRUST titers are useful in improving efficacy monitoring in syphilis patients.