儿童塑型性支气管炎临床研究进展
Progress in Clinical Research on Plastic Bronchitis in Children
DOI: 10.12677/acm.2025.151296, PDF,   
作者: 蔡 泷, 刘 庆, 宋建刚, 周 雪, 冯雨鑫：延安大学医学院，陕西 延安；李元霞*：延安大学附属医院儿科，陕西 延安
关键词: 塑型性支气管炎；儿童；纤维支气管镜；支气管肺泡灌洗术；Plastic Bronchitis； Children； Fiberoptic Bronchoscopy； Bronchoalveolar Lavage
摘要: 塑型性支气管炎(Plastic Bronchitis, PB)是一种罕见但危及生命的呼吸系统疾病，其特征是支气管树状内源性异物部分或全部阻塞气道，引起患儿的肺通气功能障碍，如果缺乏有效的治疗，远期可能会导致闭塞性细支气管炎(Bronchiolitis Obliterans BO)、支气管扩张、肺气肿等。本文旨在探讨目前临床对于诊断和治疗塑型性支气管的方法，从而更好地认识塑型性支气管炎，为诊断和治疗塑型性支气管炎提供参考。
Abstract: Plastic Bronchitis (PB) is a rare but life-threatening respiratory disease, characterized by the partial or complete obstruction of the airways by endogenous foreign bodies in the bronchial tree, causing pulmonary ventilation dysfunction in children. If not effectively treated, it may lead to long-term complications such as Bronchiolitis Obliterans (BO), bronchiectasis, and emphysema. This paper aims to explore the current clinical methods for diagnosing and treating Plastic Bronchitis, in order to better understand the disease and provide references for its diagnosis and treatment.
文章引用：蔡泷, 刘庆, 宋建刚, 周雪, 冯雨鑫, 李元霞. 儿童塑型性支气管炎临床研究进展[J]. 临床医学进展, 2025, 15(1): 2259-2263. https://doi.org/10.12677/acm.2025.151296

参考文献

[1] Patel, N., Patel, M., Inja, R., et al. (2021) Plastic Bronchitis in Adult and Pediatric Patients: A Review of Its Presentation, Diagnosis, and Treatment. Missouri Medicine, 118, 363-373.
[2] Rubin, B.K. (2016) Plastic Bronchitis. Clinics in Chest Medicine, 37, 405-408. [Google Scholar] [CrossRef] [PubMed]
[3] 田杰, 金玉, 刘素琴. 儿童塑型性支气管炎研究进展[J]. 国际医药卫生导报, 2022, 28(6): 805-808.
[4] Kunder, R., Kunder, C., Sun, H.Y., Berry, G., Messner, A., Frankovich, J., et al. (2013) Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology. Case Reports in Pulmonology, 2013, Article ID: 649365. [Google Scholar] [CrossRef] [PubMed]
[5] 焦安夏, 马渝燕, 饶小春, 等. 儿童肺炎支原体肺炎细菌性肺炎所致塑型性支气管炎15例临床分析[J]. 中国循证儿科杂志, 2010, 5(4): 294-298.
[6] 郭永盛, 邹映雪, 翟嘉, 等. 73例儿童Ⅰ型塑型性支气管炎临床特征分析[J]. 天津医科大学学报, 2017, 23(5): 422-425.
[7] Huang, F., Gu, W., Diwu, J., Zhang, X., He, Y., Zhang, Y., et al. (2023) Etiology and Clinical Features of Infection-Associated Plastic Bronchitis in Children. BMC Infectious Diseases, 23, Article No. 588. [Google Scholar] [CrossRef] [PubMed]
[8] Wang, L., Wang, W., Sun, J., Ni, S., Ding, J., Zhu, Y., et al. (2020) Efficacy of Fiberoptic Bronchoscopy and Bronchoalveolar Lavage in Childhood‐Onset, Complicated Plastic Bronchitis. Pediatric Pulmonology, 55, 3088-3095. [Google Scholar] [CrossRef] [PubMed]
[9] Ntiamoah, P., Mukhopadhyay, S., Ghosh, S. and Mehta, A.C. (2021) Recycling Plastic: Diagnosis and Management of Plastic Bronchitis among Adults. European Respiratory Review, 30, Article 210096. [Google Scholar] [CrossRef] [PubMed]
[10] Seear, M., Hui, H., Magee, F., Bohn, D. and Cutz, E. (1997) Bronchial Casts in Children: A Proposed Classification Based on Nine Cases and a Review of the Literature. American Journal of Respiratory and Critical Care Medicine, 155, 364-370. [Google Scholar] [CrossRef] [PubMed]
[11] 翟嘉, 邹映雪, 张文双, 等. 儿童塑型性支气管炎53例临床回顾分析[J]. 中国实用儿科杂志, 2016, 31(3): 211-214.
[12] Yuan, L., Huang, J., Zhu, Q., Li, M. and Zhuo, Z. (2020) Plastic Bronchitis Associated with Adenovirus Serotype 7 in Children. BMC Pediatrics, 20, Article No. 268. [Google Scholar] [CrossRef] [PubMed]
[13] Zhong, H., Yin, R., Zhao, R., Jiang, K., Sun, C. and Dong, X. (2021) Analysis of Clinical Characteristics and Risk Factors of Plastic Bronchitis in Children with Mycoplasma Pneumoniae Pneumonia. Frontiers in Pediatrics, 9, Article 735093. [Google Scholar] [CrossRef] [PubMed]
[14] Grutter, G., Di Carlo, D., Gandolfo, F., Adorisio, R., Alfieri, S., Michielon, G., et al. (2012) Plastic Bronchitis after Extracardiac Fontan Operation. The Annals of Thoracic Surgery, 94, 860-864. [Google Scholar] [CrossRef] [PubMed]
[15] Languepin, J., Scheinmann, P., Mahut, B., Le Bourgeois, M., Jaubert, F., Brunelle, F., et al. (1999) Bronchial Casts in Children with Cardiopathies: The Role of Pulmonary Lymphatic Abnormalities. Pediatric Pulmonology, 28, 329-336. [Google Scholar] [CrossRef] 
[16] Madsen, P., Shah, S. and Rubin, B. (2005) Plastic Bronchitis: New Insights and a Classification Scheme. Paediatric Respiratory Reviews, 6, 292-300. [Google Scholar] [CrossRef] [PubMed]
[17] Jin, P., Zhao, L., Zhang, T., Di, H. and Guo, W. (2024) Establishment of a Mouse Model of Mycoplasma Pneumoniae-Induced Plastic Bronchitis. Microorganisms, 12, Article 1132. [Google Scholar] [CrossRef] [PubMed]
[18] Majdalany, B.S., Khayat, M., Sanogo, M.L., et al. (2018) Direct Trans-Cervical Endolymphatic Thoracic Duct Stent-Graft for Plastic Bronchitis. Lymphology, 51, 97-101.
[19] Chen, X., Wu, S., Huang, Z., Lin, Y., Xu, J., Xu, Q., et al. (2024) Plastic Bronchitis in Children: A Review of 55 Cases over a 10‐Year Period. International Journal of Pediatrics, 2024, Article ID: 9271324. [Google Scholar] [CrossRef] [PubMed]
[20] Zhao, L., Zhang, T., Cui, X., Zhao, L., Zheng, J., Ning, J., et al. (2022) Development and Validation of a Nomogram to Predict Plastic Bronchitis in Children with Refractory Mycoplasma pneumoniae Pneumonia. BMC Pulmonary Medicine, 22, Article No. 253. [Google Scholar] [CrossRef] [PubMed]
[21] 张宁, 孙静涛, 李静, 等. 儿童塑型性支气管炎MRI应用价值[J]. 中国实验诊断学, 2024, 28(9): 1068-1071.
[22] Kallam, E.F., Kasi, A.S., Patki, R., Silva, G.L., Simon, D.M., Caltharp, S., et al. (2021) Bronchoscopic Interventions for Plastic Bronchitis in Children without Structural Heart Disease. European Journal of Pediatrics, 180, 3547-3554. [Google Scholar] [CrossRef] [PubMed]
[23] Wang, L., Wang, W., Sun, J., Ni, S., Ding, J., Zhu, Y., et al. (2020) Efficacy of Fiberoptic Bronchoscopy and Bronchoalveolar Lavage in Childhood‐Onset, Complicated Plastic Bronchitis. Pediatric Pulmonology, 55, 3088-3095. [Google Scholar] [CrossRef] [PubMed]
[24] 王文磊, 李芳. 纤维支气管镜在儿童塑形性支气管炎诊治中的价值研究[J]. 重庆医学, 2016, 45(32): 4490-4492.
[25] Kumar, A., Jat, K.R., Srinivas, M. and Lodha, R. (2018) Nebulized N-Acetylcysteine for Management of Plastic Bronchitis. Indian Pediatrics, 55, 701-703. [Google Scholar] [CrossRef] [PubMed]
[26] Robinson, M., Smiley, M., Kotha, K. and Udoji, T. (2016) Plastic Bronchitis Treated with Topical Tissue-Type Plasminogen Activator and Cryotherapy. Clinical Pediatrics, 55, 1171-1175. [Google Scholar] [CrossRef] [PubMed]
[27] Kim, E.J., Park, J.E., Kim, D.H. and Lee, J. (2012) Plastic Bronchitis in an Adult with Asthma. Tuberculosis and Respiratory Diseases, 73, 122-126. [Google Scholar] [CrossRef] [PubMed]
[28] Soyer, T., Yalcin, Ş., Emiralioğlu, N., Yilmaz, E.A., Soyer, O., Orhan, D., et al. (2016) Use of Serial Rigid Bronchoscopy in the Treatment of Plastic Bronchitis in Children. Journal of Pediatric Surgery, 51, 1640-1643. [Google Scholar] [CrossRef] [PubMed]
[29] Sriratanaviriyakul, N., Lam, F., Morrissey, B.M., Stollenwerk, N., Schivo, M. and Yoneda, K.Y. (2015) Safety and Clinical Utility of Flexible Bronchoscopic Cryoextraction in Patients with Non-Neoplasm Tracheobronchial Obstruction. Journal of Bronchology & Interventional Pulmonology, 22, 288-293. [Google Scholar] [CrossRef] [PubMed]
[30] Moslehi, M.A. (2020) Foreign Body Retrieval by Using Flexible Cryoprobe in Children. Journal of Bronchology & Interventional Pulmonology, 28, 103-106. [Google Scholar] [CrossRef] [PubMed]
[31] Gipsman, A.I., Feld, L., Johnson, B., Needleman, J.P., Boas, H., Lin, N., et al. (2023) Eosinophilic Plastic Bronchitis: Case Series and Review of the Literature. Pediatric Pulmonology, 58, 3023-3031. [Google Scholar] [CrossRef] [PubMed]

为你推荐