接种九价HPV疫苗引起药物性肝损伤1例
A Case of Drug-Induced Liver Injury Caused by Vaccination with Nine-Valent HPV Vaccine
DOI: 10.12677/acm.2025.152325, PDF,   
作者: 吕 洁, 周鸿科*：暨南大学附属第一医院消化内科，广东 广州
关键词: 九价HPV疫苗；肝毒性；诊断；药物性肝损伤；肝炎；Nine-Valent HPV Vaccine； Hepatotoxicity； Diagnosis； Drug-Induced Liver Injury； Hepatitis
摘要: 目前，国内尚无关于九价人乳头瘤病毒疫苗导致药物性肝损伤的报道，但这一问题应引起临床医师的高度重视。现报道1例中年女性患者，在接种九价HPV疫苗第二针后出现乏力、纳差、巩膜及皮肤黄染，经护肝、利胆等对症支持治疗后症状好转，但临床医生未能及时说服患者完善相关检查进一步排查药物性肝损伤，致患者继续接种第三针，出现肝损慢性化、严重化。经进一步的护肝、利胆、营养支持等对症支持治疗并随访5个月，患者肝脏功能已恢复正常。通过该病例以期提高临床对药物性肝损伤的认知及诊治水平。
Abstract: At present, there is no report on drug-induced liver injury caused by nine-valent human papillomavirus vaccine in China, but this problem should be highly valued by clinicians. It is reported that a middle-aged female patient suffered from fatigue, poor appetite, yellow staining of sclera and skin after the second dose of nine-valent HPV vaccine. After symptomatic support treatment such as protecting the liver and promoting gallbladder function, the symptoms improved, but the clinician failed to persuade the patient to improve the relevant examination in time to further investigate the drug-induced liver injury, resulting in the patient continuing to receive the third dose, resulting in chronic and severe liver damage. After further symptomatic support treatment such as liver protection, choleretic and nutritional support and follow-up for 5 months, the liver function of the patient has returned to normal. Through this case, we hope to improve the clinical cognition, diagnosis and treatment of drug-induced liver injury.
文章引用：吕洁, 周鸿科. 接种九价HPV疫苗引起药物性肝损伤1例[J]. 临床医学进展, 2025, 15(2): 129-134. https://doi.org/10.12677/acm.2025.152325

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