铁代谢与动脉粥样硬化的研究进展
Research Progress of Iron Metabolism and Atherosclerosis
DOI: 10.12677/acm.2025.152365, PDF,    科研立项经费支持
作者: 杨沅久:西安医学院研究生工作部,陕西 西安;冯旭阳*:西京医院心血管内科,陕西 西安
关键词: 铁超载铁死亡铁调素动脉粥样硬化巨噬细胞Iron Overload Ferroptosis Hepcidin Atherosclerosis Macrophage
摘要: 动脉粥样硬化是心脑血管疾病的重要病理基础之一,其病理基础复杂多变,目前公认的病理机制主要为脂代谢紊乱及炎症刺激。铁作为维持生物体生命的重要微量元素,参与了人体中许多的生物过程,如氧代谢、脂代谢及细胞呼吸等。近期有关铁死亡的研究将铁与动脉粥样硬化联系起来,阐明铁可能参与动脉粥样硬化的发生发展过程,本文将综述有关铁代谢及其在动脉粥样硬化发生发展中可能的机制的文章并探讨未来针对动脉粥样硬化的可能潜在治疗靶点。
Abstract: Atherosclerosis is one of the important pathological bases of cardiovascular and cerebrovascular diseases. Its pathological basis is complex and changeable. At present, the recognized pathological mechanism is mainly lipid metabolism disorder and inflammatory stimulation. Iron, as an important trace element for maintaining biological life, participates in many biological processes in the human body, such as oxygen metabolism, lipid metabolism, and cellular respiration. Recent studies on ferroptosis have linked iron with atherosclerosis, and clarified that iron may participate in the occurrence and development of atherosclerosis. This article will review studies on iron metabolism and its possible mechanism in the occurrence and development of atherosclerosis, and explore potential therapeutic targets for atherosclerosis in the future.
文章引用:杨沅久, 冯旭阳. 铁代谢与动脉粥样硬化的研究进展[J]. 临床医学进展, 2025, 15(2): 443-449. https://doi.org/10.12677/acm.2025.152365

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