七种自身抗体对肺癌早期筛查敏感性和特异性的价值研究

Study on the Sensitivity and Specificity of Seven Autoantibodies for Early Screening of Lung Cancer

摘要: 全球癌症相关致死的一个最主要原因就是肺癌。主要原因是肺癌患者早期临床表现不明显，等到发现时已经是中晚期，所以我们急需要找到一种在肺癌发展早期就能及时发现的检测手段，这种检测手段就是肺癌七种自身抗体[性别决定相关基因簇2 (Sox2)、蛋白基因产物9.5 (PGP9.5)、黑色素瘤抗原A1 (MAGE-A1)、癌相关基因(CAGE)、G抗原7 (GAGE7)、肿瘤抗原4-5 (GBU4-5)、P53]检测，其不仅操作简便，而且患者配合度高，相比较于低剂量螺旋CT，PET-CT等检查手段价格低廉易接受，且对患者损伤较小。目前临床上常用的肿瘤标志物如CEA、CYFRA21-1、SCCA等在肺癌早期筛查中有一定作用，但灵敏度较低，特异性不强，应用受限。本文对七抗体自身特点以及其联合其他手段对肺癌进行早期筛查的临床价值进行综述。

Abstract: One of the leading causes of cancer-related deaths worldwide is lung cancer. The main reason is that the early clinical manifestations of lung cancer patients are not obvious, and when it is discovered, it is already in the middle and late stages, so we urgently need to find a detection method that can detect lung cancer in the early stage of development. This test means seven autoantibodies to lung cancer [sex determination related gene cluster 2 (Sox2), protein gene product 9.5 (PGP9.5), melanoma antigen A1 (MAGE-A1), cancer related gene (CAGE), G antigen 7 (GAGE7), and tumor antigen The detection of 4-5 (GBU4-5) and P53] is not only simple to operate, but also has high patient cooperation. Compared with low-dose spiral CT, PET-CT and other examination methods, it is cheap and acceptable, and has less damage to patients. Currently, commonly used tumor markers such as CEA, CYFRA21-1 and SCCA play a certain role in the early screening of lung cancer, but the sensitivity is low, the specificity is not strong, and the application is limited. This article reviewed the clinical value of seven antibody combined with other methods in early screening of lung cancer.