咪达唑仑在儿童程序性镇静中的应用进展

Advances in the Application of Midazolam for Procedural Sedation in Children

摘要: 咪达唑仑作为一种短效苯二氮卓类镇静剂，起效迅速且恢复快，在临床上得到广泛应用，特别是在儿童程序性镇静领域。咪达唑仑存在剂量依赖性的呼吸抑制，这使得临床医生在选择镇静方案时需要充分评估患者的具体情况。此外，咪达唑仑单独使用时效果不佳，临床上常与其他镇静药物联合使用，如与丙泊酚、右美托咪定、氯胺酮等联合使用，能够在保证镇静深度的同时，减少较大剂量的单一药物可能引起的不良反应。本文将系统综述咪达唑仑在儿童程序性镇静中的研究进展，探讨其临床应用中的优势与挑战，为进一步的研究和临床实践提供指导。

Abstract: Midazolam, a short-acting benzodiazepine sedative, acts rapidly and has a quick recovery time, making it widely used in clinical practice, particularly in pediatric procedural sedation. Midazolam has a dose-dependent respiratory depressant effect, which requires clinicians to carefully assess the patient’s specific condition when selecting a sedation regimen. Additionally, midazolam is less effective when used alone, and is often combined with other sedative drugs in clinical practice, such as propofol, dexmedetomidine, and ketamine. This combination can ensure adequate sedation depth while minimizing the adverse effects associated with higher doses of a single drug. This article systematically reviews the research progress of midazolam in pediatric procedural sedation, discussing its advantages and challenges in clinical applications, and providing guidance for further research and clinical practice.