NRF2在肺纤维化中作用机制及相关治疗的研究进展
Research Progress on the Mechanism of Action of NRF2 in Pulmonary Fibrosis and Related Therapies
DOI: 10.12677/acm.2025.152377, PDF,    科研立项经费支持
作者: 匡 洁：南华大学附属怀化医院呼吸内科，湖南 怀化；贺兼斌*：湖南医药学院总医院呼吸内科，湖南 怀化
关键词: NRF2；肺纤维化；作用机制；治疗；NRF2； Pulmonary Fibrosis； Mechanism of Action； Treatment
摘要: 肺纤维化(Pulmonary fibrosis, PF)是一种致死性高、几乎不可逆转的肺部疾病，目前发病机制不是十分明确，且治疗手段极其匮乏，因此寻找新的治疗策略成为当务之急。核因子E2相关因子2 (Nuclear factor erythroid 2-related factor 2, NRF2)是细胞内调节抗氧化应激、炎症反应及众多生理过程的关键转录因子，近年来的研究表明，众多药物可以通过作用于NRF2相关机制发挥抗PF的功效。本文就NRF2的结构与功能、参与PF的作用途径及相关治疗作一简要综述，以期深入发掘NRF2作为治疗PF靶点的潜力。
Abstract: Pulmonary fibrosis (PF), a pulmonary disorder characterized by high lethality and near-irreversibility, has an incompletely elucidated pathogenesis at present, and the available treatment modalities are severely limited. Consequently, the pursuit of novel therapeutic strategies has emerged as an urgent necessity. Nuclear factor erythroid 2-related factor 2 (NRF2), a pivotal transcription factor within cells, is responsible for modulating antioxidant stress, inflammatory responses, and a multitude of physiological processes. Recent investigations have demonstrated that numerous drugs can exert anti-PF effects by acting on NRF2-related mechanisms. This article presents a concise review of the structure and function of NRF2, its pathways involved in PF, and related treatments, with the aim of deeply exploring the potential of NRF2 as a therapeutic target for PF.
文章引用：匡洁, 贺兼斌. NRF2在肺纤维化中作用机制及相关治疗的研究进展[J]. 临床医学进展, 2025, 15(2): 536-545. https://doi.org/10.12677/acm.2025.152377

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