miRNAs在骨髓间充质干细胞成骨分化中的作用
The Role of miRNAs in the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
DOI: 10.12677/jcpm.2025.41051, PDF,   
作者: 夏振然*, 肖 军, 郭天琦, 常志强#：内蒙古医科大学第二附属医院创伤中心，内蒙古 呼和浩特
关键词: 骨髓间充质干细胞；成骨分化；信号通路；miRNAs；Bone Marrow Mesenchymal Stem Cells； Osteogenic Differentiation； Signaling Pathways； miRNAs
摘要: 间充质干细胞(MSC)，也称为多能基质细胞，是一种首次在骨髓中发现的非造血干细胞群，目前已从各种成体组织来源中分离出来，是能够分化为多种间充质组织(如脂肪和骨骼)的成熟细胞的多能细胞。MicroRNAs (miRNA)是一种高度保守的内源性非蛋白质编码RNA，通过翻译抑制或降解其靶标来调节基因表达，在调节BMSC分化中起主要作用。本文探讨了miRNAs骨髓间充质干细胞成骨分化中的作用。
Abstract: Mesenchymal stem cells (MSCs), also known as pluripotent stromal cells, are a population of non-hematopoietic stem cells first discovered in the bone marrow that have been isolated from various adult tissue sources and are pluripotent cells capable of differentiating into mature cells of a variety of mesenchymal tissues, such as fat and bone. MicroRNAs (miRNAs) are highly conserved endogenous non-protein-coding RNAs that play a major role in regulating BMSC differentiation by translating inhibition or degradation of their targets to regulate gene expression. This article explores the role of miRNAs in osteogenic differentiation of bone marrow mesenchymal stem cells.
文章引用：夏振然, 肖军, 郭天琦, 常志强. miRNAs在骨髓间充质干细胞成骨分化中的作用[J]. 临床个性化医学, 2025, 4(1): 334-340. https://doi.org/10.12677/jcpm.2025.41051

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