凋亡和焦亡对胶质瘤作用的研究进展
Research Progress on the Effects of Apoptosis and Pyroptosis on Glioma
DOI: 10.12677/jcpm.2025.41052, PDF,   
作者: 李 卓, 宋国智*：承德医学院研究生学院，河北 承德；邯郸市中心医院神经外五科，河北 邯郸
关键词: 胶质瘤；焦亡；凋亡；Glioma； Pyroptosis； Apoptosis
摘要: 细胞凋亡与焦亡作为两种重要的程序性细胞死亡方式，在胶质瘤的发生、发展及治疗中扮演着至关重要的角色。本文综述了近年来关于凋亡和焦亡在胶质瘤作用方面的研究进展，以期为胶质瘤的治疗提供新的思路。
Abstract: Apoptosis and pyroptosis, as two important modes of programmed cell death, play crucial roles in the occurrence, development, and treatment of gliomas. This article reviews the research progress on the role of apoptosis and pyroptosis in glioma in recent years, in order to provide new ideas for the treatment of glioma.
文章引用：李卓, 宋国智. 凋亡和焦亡对胶质瘤作用的研究进展[J]. 临床个性化医学, 2025, 4(1): 341-348. https://doi.org/10.12677/jcpm.2025.41052

参考文献

[1] Qian, Y., Gong, Y., Fan, Z., Luo, G., Huang, Q., Deng, S., et al. (2020) Molecular Alterations and Targeted Therapy in Pancreatic Ductal Adenocarcinoma. Journal of Hematology & Oncology, 13, Article No. 130. [Google Scholar] [CrossRef] [PubMed]
[2] Galluzzi, L., Vitale, I., Aaronson, S.A., Abrams, J.M., Adam, D., Agostinis, P., et al. (2018) Molecular Mechanisms of Cell Death: Recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death & Differentiation, 25, 486-541. [Google Scholar] [CrossRef] [PubMed]
[3] 刘雪文, 杨锐, 赵红艳, 等. 重楼皂苷Ⅰ直接靶向STAT3抑制神经胶质瘤U251细胞增殖并诱导凋亡[J]. 肿瘤, 2020, 40(3): 163-171.
[4] Li, L., Li, Y. and Bai, Y. (2020) Role of GSDMB in Pyroptosis and Cancer. Cancer Management and Research, 12, 3033-3043. [Google Scholar] [CrossRef] [PubMed]
[5] Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., et al. (2016) Pore-Forming Activity and Structural Autoinhibition of the Gasdermin Family. Nature, 535, 111-116. [Google Scholar] [CrossRef] [PubMed]
[6] Chao, K.L., Kulakova, L. and Herzberg, O. (2017) Gene Polymorphism Linked to Increased Asthma and IBD Risk Alters Gasdermin-B Structure, a Sulfatide and Phosphoinositide Binding Protein. Proceedings of the National Academy of Sciences, 114, E1128-E1137. [Google Scholar] [CrossRef] [PubMed]
[7] Ruan, J., Xia, S., Liu, X., Lieberman, J. and Wu, H. (2018) Cryo-EM Structure of the Gasdermin A3 Membrane Pore. Nature, 557, 62-67. [Google Scholar] [CrossRef] [PubMed]
[8] Tamura, M., Tanaka, S., Fujii, T., Aoki, A., Komiyama, H., Ezawa, K., et al. (2007) Members of a Novel Gene Family, Gsdm, Are Expressed Exclusively in the Epithelium of the Skin and Gastrointestinal Tract in a Highly Tissue-Specific Manner. Genomics, 89, 618-629. [Google Scholar] [CrossRef] [PubMed]
[9] 陈晶晶, 刘玲, 曹梦瑶, 等. PABA/一氧化氮经活性氧-线粒体膜电位途径诱导HepG2细胞凋亡的研究[J]. 中国临床药理学杂志, 2019, 35(19): 2356-2360.
[10] Wei, J., Xu, Z., Chen, X., et al. (2020) Overexpression of GSDMC Is a Prognostic Factor for Predicting a Poor Outcome in Lung Adenocarcinoma. Molecular Medicine Reports, 21, 360-370.
[11] Zhang, Z., Zhang, Y., Xia, S., Kong, Q., Li, S., Liu, X., et al. (2020) Gasdermin E Suppresses Tumour Growth by Activating Anti-Tumour Immunity. Nature, 579, 415-420. [Google Scholar] [CrossRef] [PubMed]
[12] 李超, 重楼皂苷Ⅶ抑制胶质瘤U251细胞增殖的机制及其与替莫唑胺联合用药可能性的探究[D]: [硕士学位论文]. 成都: 四川农业大学, 2020.
[13] Tan, J., Zhuo, Z. and Si, Y. (2023) Application of Pyroptosis in Tumor Research (Review). Oncology Letters, 26, Article No. 376. [Google Scholar] [CrossRef] [PubMed]
[14] Tang, D., Kang, R., Berghe, T.V., Vandenabeele, P. and Kroemer, G. (2019) The Molecular Machinery of Regulated Cell Death. Cell Research, 29, 347-364. [Google Scholar] [CrossRef] [PubMed]
[15] Bertheloot, D., Latz, E. and Franklin, B.S. (2021) Necroptosis, Pyroptosis and Apoptosis: An Intricate Game of Cell Death. Cellular & Molecular Immunology, 18, 1106-1121. [Google Scholar] [CrossRef] [PubMed]
[16] Zhao, W., Zhang, L., Zhang, Y., Jiang, Z., Lu, H., Xie, Y., et al. (2023) The CDK Inhibitor AT7519 Inhibits Human Glioblastoma Cell Growth by Inducing Apoptosis, Pyroptosis and Cell Cycle Arrest. Cell Death & Disease, 14, Article No. 11. [Google Scholar] [CrossRef] [PubMed]
[17] Ye, Y., Dai, Q. and Qi, H. (2021) A Novel Defined Pyroptosis-Related Gene Signature for Predicting the Prognosis of Ovarian Cancer. Cell Death Discovery, 7, Article No. 71. [Google Scholar] [CrossRef] [PubMed]
[18] Xu, P., Zhang, X., Liu, Q., Xie, Y., Shi, X., Chen, J., et al. (2019) Microglial TREM-1 Receptor Mediates Neuroinflammatory Injury via Interaction with SYK in Experimental Ischemic Stroke. Cell Death & Disease, 10, Article No. 555. [Google Scholar] [CrossRef] [PubMed]
[19] Belykh, E., Shaffer, K.V., Lin, C., Byvaltsev, V.A., Preul, M.C. and Chen, L. (2020) Blood-Brain Barrier, Blood-Brain Tumor Barrier, and Fluorescence-Guided Neurosurgical Oncology: Delivering Optical Labels to Brain Tumors. Frontiers in Oncology, 10, Article 739. [Google Scholar] [CrossRef] [PubMed]
[20] Broz, P., Pelegrín, P. and Shao, F. (2019) The Gasdermins, a Protein Family Executing Cell Death and Inflammation. Nature Reviews Immunology, 20, 143-157. [Google Scholar] [CrossRef] [PubMed]
[21] Fischer, F.A., Chen, K.W. and Bezbradica, J.S. (2021) Posttranslational and Therapeutic Control of Gasdermin-Mediated Pyroptosis and Inflammation. Frontiers in Immunology, 12, Article 661162. [Google Scholar] [CrossRef] [PubMed]
[22] Van Opdenbosch, N. and Lamkanfi, M. (2019) Caspases in Cell Death, Inflammation, and Disease. Immunity, 50, 1352-1364. [Google Scholar] [CrossRef] [PubMed]
[23] Brennan, M.A. and Cookson, B.T. (2000) Salmonella Induces Macrophage Death by Caspase‐1‐Dependent Necrosis. Molecular Microbiology, 38, 31-40. [Google Scholar] [CrossRef] [PubMed]
[24] 陈卓, 方兴刚, 郭兴荣, 等. 基于网络药理学及实验研究探讨紫檀芪调控凋亡及GSDME介导的细胞焦亡途径抗脑胶质瘤的作用机制[J]. 中国中药杂志, 2023, 48(13): 3589-3601.
[25] Hoeper, M.M., Humbert, M., Souza, R., Idrees, M., Kawut, S.M., Sliwa-Hahnle, K., et al. (2016) A Global View of Pulmonary Hypertension. The Lancet Respiratory Medicine, 4, 306-322. [Google Scholar] [CrossRef] [PubMed]
[26] Villegas, L.R., Kluck, D., Field, C., Oberley-Deegan, R.E., Woods, C., Yeager, M.E., et al. (2013) Superoxide Dismutase Mimetic, Mnte-2-Pyp, Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension, Pulmonary Vascular Remodeling, and Activation of the NALP3 Inflammasome. Antioxidants & Redox Signaling, 18, 1753-1764. [Google Scholar] [CrossRef] [PubMed]
[27] Coll, R.C. and O’Neill, L.A.J. (2011) The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes. PLOS ONE, 6, e29539. [Google Scholar] [CrossRef] [PubMed]
[28] Marchetti, C., Chojnacki, J., Toldo, S., Mezzaroma, E., Tranchida, N., Rose, S.W., et al. (2014) A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury after Ischemia-Reperfusion in the Mouse. Journal of Cardiovascular Pharmacology, 63, 316-322. [Google Scholar] [CrossRef] [PubMed]
[29] 吴薇, 刘不悔, 万毅刚, 等. 雷公藤甲素抑制NLRP3炎症小体活化改善高糖诱导的足细胞上皮-间充质转分化[J]. 中国中药杂志, 2019, 44(24): 5457-5464.
[30] 周慧, 曲颂扬, 田立东. 雷公藤甲素对IgA肾病大鼠的肾保护作用及对NLRP3炎症小体的影响[J]. 蚌埠医学院学报, 2020, 45(12): 1593-1597, 1601.
[31] Cocco, M., Pellegrini, C., Martínez-Banaclocha, H., Giorgis, M., Marini, E., Costale, A., et al. (2017) Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease. Journal of Medicinal Chemistry, 60, 3656-3671. [Google Scholar] [CrossRef] [PubMed]